STRINGSTRING
NOS2 NOS2 I3MYM5_ICTTR I3MYM5_ICTTR RELA RELA IFNGR1 IFNGR1 PPP1R14B PPP1R14B TLR4 TLR4 Hspa1b Hspa1b HSPA1L HSPA1L NFKBIB NFKBIB CCR5 CCR5 JAK1 JAK1 LOC101957991 LOC101957991 SOCS1 SOCS1 LOC101959667 LOC101959667 CASP10 CASP10 I3NC87_ICTTR I3NC87_ICTTR I3NCK5_ICTTR I3NCK5_ICTTR TLR2 TLR2 HSPA6 HSPA6 TGFB3 TGFB3 CD40 CD40 MAPK14 MAPK14 MAPK13 MAPK13 LAMB1 LAMB1 Bcl2l1 Bcl2l1 IRAK1 IRAK1 ENSSTOP00000025685 ENSSTOP00000025685 LAMB4 LAMB4 ENSSTOP00000026081 ENSSTOP00000026081 ENSSTOP00000026508 ENSSTOP00000026508 LAMC3 LAMC3 IKBKG IKBKG ENSSTOP00000027174 ENSSTOP00000027174 AKT1 AKT1 BIRC7 BIRC7 ENSSTOP00000030003 ENSSTOP00000030003 MAPK9 MAPK9 LOC101970873 LOC101970873 ENSSTOP00000031310 ENSSTOP00000031310 LOC101978532 LOC101978532 IFNGR2 IFNGR2 MAPK3 MAPK3 TGFB2 TGFB2 IL10RB IL10RB PIK3CG PIK3CG MAPK10 MAPK10 LAMB2 LAMB2 TAB1 TAB1 AKT2 AKT2 PPIF PPIF TYK2 TYK2 HLA-DOB HLA-DOB XIAP XIAP HLA-DPA1 HLA-DPA1 HLA-DPB1 HLA-DPB1 HSPA8 HSPA8 Casp3 Casp3 IL12B IL12B PIK3R6 PIK3R6 PIK3R5 PIK3R5 LAMA4 LAMA4 BIRC3 BIRC3 Birc2 Birc2 IKBKB IKBKB CD40LG CD40LG IL10 IL10 ITGA6 ITGA6 JAK2 JAK2 LAMA3 LAMA3 STAT3 STAT3 TRAF6 TRAF6 NFKBIA NFKBIA Gnao1 Gnao1 IL10RA IL10RA LDLR LDLR BAD BAD LAMA1 LAMA1 STAT1 STAT1 GNAI3 GNAI3 LAMA2 LAMA2 LOC106144614 LOC106144614 C7orf31 C7orf31 LAMC1 LAMC1 LAMC2 LAMC2 HLA-DMA HLA-DMA MAP2K3 MAP2K3 HLA-DQB1 HLA-DQB1 LOC101968486 LOC101968486 LOC101968188 LOC101968188 TGFB1 TGFB1 TNFRSF1A TNFRSF1A HLA-DRA HLA-DRA AKT3 AKT3 HLA-DOA HLA-DOA CASP8 CASP8 NFKB1 NFKB1 GNAI1 GNAI1 MAPK8 MAPK8 TNF TNF PDPK1 PDPK1 Hspa1a Hspa1a ITGB1 ITGB1 MYD88 MYD88 Irak4 Irak4 IL12A IL12A MAPK1 MAPK1 IFNG IFNG MAPK12 MAPK12 MAPK11 MAPK11 LOC101970595 LOC101970595 GNAI2 GNAI2 CHUK CHUK TAB2 TAB2 ALOX5 ALOX5 BCL2 BCL2 LAMB3 LAMB3 LAMA5 LAMA5 I3MXS4_ICTTR I3MXS4_ICTTR MAP3K7 MAP3K7 ENSSTOP00000032525 ENSSTOP00000032525
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1070 aa)
I3MYM5_ICTTRTIR domain-containing protein. (785 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IFNGR1Interferon gamma receptor 1. (476 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
Hspa1bHeat shock protein family A (Hsp70) member 1B. (641 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
NFKBIBNFKB inhibitor beta. (359 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (351 aa)
JAK1Tyrosine-protein kinase. (1142 aa)
LOC101957991Ig-like domain-containing protein. (249 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
LOC101959667Ig-like domain-containing protein. (272 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
I3NC87_ICTTRCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
I3NCK5_ICTTRCARD domain-containing protein. (102 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CD40CD40 molecule. (284 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
Bcl2l1BH4_2 domain-containing protein. (233 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
ENSSTOP00000025685Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
LAMB4Laminin subunit beta 4. (1539 aa)
ENSSTOP00000026081Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSSTOP00000026508BH4_2 domain-containing protein. (224 aa)
LAMC3Laminin subunit gamma 3. (1412 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
ENSSTOP00000027174Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (101 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BIRC7Baculoviral IAP repeat containing 7. (304 aa)
ENSSTOP00000030003Uncharacterized protein. (546 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC101970873Ig-like domain-containing protein. (251 aa)
ENSSTOP00000031310Uncharacterized protein; Belongs to the peptidase C14A family. (233 aa)
LOC101978532Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (100 aa)
IFNGR2Interferon gamma receptor 2. (306 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IL10RBInterleukin 10 receptor subunit beta. (334 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1071 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
LAMB2Laminin subunit beta 2. (1846 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (207 aa)
TYK2Tyrosine-protein kinase. (1194 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (282 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (288 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
Casp3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (748 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (871 aa)
LAMA4Laminin subunit alpha 4. (1813 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
Birc2Uncharacterized protein. (611 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (259 aa)
IL10Interleukin 10. (178 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1091 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LAMA3Laminin subunit alpha 3. (3296 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
Gnao1G protein subunit alpha o1. (344 aa)
IL10RAInterleukin 10 receptor subunit alpha. (576 aa)
LDLRLow density lipoprotein receptor. (863 aa)
BADBCL2 associated agonist of cell death. (208 aa)
LAMA1Laminin subunit alpha 1. (3004 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
GNAI3G protein subunit alpha i3. (354 aa)
LAMA2Laminin subunit alpha 2. (3117 aa)
LOC106144614Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
C7orf31Chromosome 7 open reading frame 31. (591 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
LAMC2Laminin subunit gamma 2. (1192 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (292 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (269 aa)
LOC101968486Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
LOC101968188Ig-like domain-containing protein. (266 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (220 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
GNAI1G protein subunit alpha i1. (354 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
Hspa1aUncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Irak4Interleukin 1 receptor associated kinase 4. (457 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
LOC101970595Ig-like domain-containing protein. (264 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
ALOX5Arachidonate 5-lipoxygenase. (663 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
LAMB3Laminin subunit beta 3. (1173 aa)
LAMA5Laminin subunit alpha 5. (3474 aa)
I3MXS4_ICTTRCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSSTOP00000032525Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (94 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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