STRINGSTRING
I3N7P8_ICTTR I3N7P8_ICTTR Rps6kb1 Rps6kb1 ERAS ERAS GNA11 GNA11 CCR3 CCR3 LOC101965888 LOC101965888 ITGAV ITGAV I3NBL8_ICTTR I3NBL8_ICTTR GNA12 GNA12 CASP10 CASP10 I3NC87_ICTTR I3NC87_ICTTR I3NCK5_ICTTR I3NCK5_ICTTR LOC101969207 LOC101969207 TAPBP TAPBP ARHGEF11 ARHGEF11 LOC101967338 LOC101967338 LOC101958159 LOC101958159 GNG7 GNG7 CX3CL1 CX3CL1 MAPK14 MAPK14 CALM2 CALM2 Gng10 Gng10 GSK3B GSK3B MAPK13 MAPK13 ATF4 ATF4 LOC101967717 LOC101967717 LOC101967997 LOC101967997 LOC101960640 LOC101960640 ENSSTOP00000024190 ENSSTOP00000024190 ITPR2 ITPR2 PLCB4 PLCB4 CRK CRK FADD FADD HLA-E HLA-E LOC101968118 LOC101968118 PTGER3 PTGER3 ITPR3 ITPR3 ENSSTOP00000025685 ENSSTOP00000025685 PRKCG PRKCG PIK3R1 PIK3R1 ENSSTOP00000026081 ENSSTOP00000026081 ENSSTOP00000026262 ENSSTOP00000026262 TRAF5 TRAF5 LOC101969049 LOC101969049 Gnas Gnas CREB5 CREB5 IKBKG IKBKG CALM3 CALM3 ITPR1 ITPR1 ENSSTOP00000027174 ENSSTOP00000027174 PLCB2 PLCB2 B2M B2M LOC101967288 LOC101967288 LOC101975023 LOC101975023 ENSSTOP00000028389 ENSSTOP00000028389 AKT1 AKT1 HRAS HRAS ADCY7 ADCY7 Akap13 Akap13 ENSSTOP00000028887 ENSSTOP00000028887 PRKACB PRKACB NFATC2 NFATC2 Pik3r3 Pik3r3 ATF6B ATF6B BAK1 BAK1 Pik3cd Pik3cd SOS1 SOS1 ENSSTOP00000029937 ENSSTOP00000029937 PTK2B PTK2B ADCY8 ADCY8 PLCB3 PLCB3 ENSSTOP00000030691 ENSSTOP00000030691 Gng14 Gng14 ENSSTOP00000031001 ENSSTOP00000031001 Csde1 Csde1 PTK2 PTK2 ENSSTOP00000031310 ENSSTOP00000031310 LOC101978532 LOC101978532 Cgas Cgas MTOR MTOR ENSSTOP00000032237 ENSSTOP00000032237 ENSSTOP00000032295 ENSSTOP00000032295 ROCK2 ROCK2 ENSSTOP00000032525 ENSSTOP00000032525 PPP3CB PPP3CB ADCY5 ADCY5 CCND1 CCND1 LOC101967545 LOC101967545 MAPK3 MAPK3 RB1 RB1 GNG3 GNG3 Cdk4 Cdk4 PIK3CB PIK3CB IL10RB IL10RB RIPK1 RIPK1 GNA13 GNA13 Pik3r2 Pik3r2 IL1B IL1B PRKACA PRKACA Map2k2 Map2k2 ADCY4 ADCY4 E2F1 E2F1 Itgb3 Itgb3 NFATC4 NFATC4 AKT2 AKT2 PRKCA PRKCA CXCL8 CXCL8 Tap2 Tap2 TAP1 TAP1 TSC1 TSC1 ARHGEF1 ARHGEF1 Casp3 Casp3 RHEBL1 RHEBL1 BCAR1 BCAR1 ADCY6 ADCY6 GNG13 GNG13 GNG12 GNG12 RHEB RHEB Rhoa Rhoa I3M4W8_ICTTR I3M4W8_ICTTR ADCY2 ADCY2 MYC MYC ADCY9 ADCY9 GNB4 GNB4 CREB3 CREB3 IKBKB IKBKB SP1 SP1 CXCL12 CXCL12 PTRHD1 PTRHD1 ADCY3 ADCY3 CXCR4 CXCR4 EGFR EGFR STAT3 STAT3 RAC1 RAC1 Eif4ebp1 Eif4ebp1 PDIA3 PDIA3 NFKBIA NFKBIA GNGT2 GNGT2 Faslg Faslg Gnao1 Gnao1 IL10RA IL10RA CALML3 CALML3 NFATC1 NFATC1 TBK1 TBK1 GNG5 GNG5 CRKL CRKL GNAI3 GNAI3 ADCY1 ADCY1 CALR CALR LOC106144614 LOC106144614 C7orf31 C7orf31 VEGFA VEGFA MAP2K1 MAP2K1 IL6R IL6R KRAS KRAS E2F2 E2F2 Ptgs2 Ptgs2 GNGT1 GNGT1 GNG11 GNG11 LOC101962660 LOC101962660 CREB3L2 CREB3L2 ELK1 ELK1 TNFRSF1A TNFRSF1A GNB1 GNB1 AKT3 AKT3 PDGFRA PDGFRA CASP8 CASP8 TRADD TRADD NFKB1 NFKB1 PPP3CA PPP3CA TRAF2 TRAF2 GNAI1 GNAI1 PRKCB PRKCB GRB2 GRB2 CREB3L1 CREB3L1 TNF TNF PIK3CA PIK3CA TSC2 TSC2 CXCR2 CXCR2 LOC101968597 LOC101968597 LOC101968303 LOC101968303 PTGER1 PTGER1 BAX BAX RAC3 RAC3 CDK6 CDK6 GNB5 GNB5 ATF2 ATF2 PXN PXN CREB3L4 CREB3L4 Mdm2 Mdm2 MAPK1 MAPK1 MAPK12 MAPK12 MAPK11 MAPK11 CALML4 CALML4 I3MPY1_ICTTR I3MPY1_ICTTR GNB3 GNB3 GNG4 GNG4 LPXN LPXN CCL5 CCL5 ARHGEF12 ARHGEF12 CTNNB1 CTNNB1 PLCB1 PLCB1 GNAI2 GNAI2 CALM1 CALM1 CHUK CHUK CREB1 CREB1 CREB3L3 CREB3L3 Ppp3r1 Ppp3r1 LOC101965906 LOC101965906 PPP3CC PPP3CC GNB2 GNB2 GNG2 GNG2 NFATC3 NFATC3 NRAS NRAS IL1R1 IL1R1 CCR1 CCR1 GNAQ GNAQ LOC101966190 LOC101966190 I3MUP6_ICTTR I3MUP6_ICTTR I3MVH6_ICTTR I3MVH6_ICTTR I3MVL6_ICTTR I3MVL6_ICTTR CALML6 CALML6 RPS6KB2 RPS6KB2 RAC2 RAC2 LOC101956844 LOC101956844 I3MXS4_ICTTR I3MXS4_ICTTR GNG8 GNG8 RELA RELA I3MZ83_ICTTR I3MZ83_ICTTR I3N090_ICTTR I3N090_ICTTR PTGER2 PTGER2 STING1 STING1 LOC101960206 LOC101960206 IRF3 IRF3 LOC101959358 LOC101959358 BID BID LOC101960961 LOC101960961 PTGER4 PTGER4 LOC101966768 LOC101966768 I3N418_ICTTR I3N418_ICTTR CCR5 CCR5 CDKN1A CDKN1A RUFY4 RUFY4 E2F3 E2F3 LOC101977967 LOC101977967 ROCK1 ROCK1 TP53 TP53 LOC101976253 LOC101976253 Rhoc Rhoc JAK1 JAK1 LOC101968765 LOC101968765 LOC101961596 LOC101961596
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I3N7P8_ICTTRIg-like domain-containing protein; Belongs to the MHC class I family. (385 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ERASES cell expressed Ras. (227 aa)
GNA11G protein subunit alpha 11. (359 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LOC101965888Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1077 aa)
I3NBL8_ICTTRMHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (245 aa)
GNA12G protein subunit alpha 12. (343 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
I3NC87_ICTTRCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
I3NCK5_ICTTRCARD domain-containing protein. (102 aa)
LOC101969207C-C motif chemokine. (136 aa)
TAPBPTAP binding protein. (464 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1494 aa)
LOC101967338Ig-like domain-containing protein; Belongs to the MHC class I family. (351 aa)
LOC101958159Ig-like domain-containing protein; Belongs to the MHC class I family. (417 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
ATF4Activating transcription factor 4. (352 aa)
LOC101967717Ig-like domain-containing protein; Belongs to the MHC class I family. (335 aa)
LOC101967997Ig-like domain-containing protein; Belongs to the MHC class I family. (352 aa)
LOC101960640Ig-like domain-containing protein; Belongs to the MHC class I family. (363 aa)
ENSSTOP00000024190Protein kinase domain-containing protein. (266 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
HLA-EMajor histocompatibility complex, class I, E; Belongs to the MHC class I family. (399 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
PTGER3Prostaglandin E receptor 3. (388 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
ENSSTOP00000025685Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSSTOP00000026081Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSSTOP00000026262Ig-like domain-containing protein; Belongs to the MHC class I family. (423 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
LOC101969049Uncharacterized protein. (174 aa)
GnasUncharacterized protein. (244 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
CALM3Calmodulin 3. (149 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
ENSSTOP00000027174Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (101 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (123 aa)
LOC101967288Uncharacterized protein. (848 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
ENSSTOP00000028389Uncharacterized protein. (113 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
Akap13Uncharacterized protein. (1423 aa)
ENSSTOP00000028887Uncharacterized protein. (184 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
NFATC2Nuclear factor of activated T cells 2. (844 aa)
Pik3r3Uncharacterized protein. (461 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
ENSSTOP00000029937Uncharacterized protein; Belongs to the calmodulin family. (67 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
ENSSTOP00000030691Ig-like domain-containing protein; Belongs to the MHC class I family. (333 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSSTOP00000031001Uncharacterized protein. (178 aa)
Csde1Uncharacterized protein. (555 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
ENSSTOP00000031310Uncharacterized protein; Belongs to the peptidase C14A family. (233 aa)
LOC101978532Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (100 aa)
CgasMab-21 domain-containing protein. (305 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
ENSSTOP00000032237Uncharacterized protein; Belongs to the calmodulin family. (148 aa)
ENSSTOP00000032295Uncharacterized protein. (488 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
ENSSTOP00000032525Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (94 aa)
PPP3CBSerine/threonine-protein phosphatase. (523 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
CCND1Cyclin D1. (250 aa)
LOC101967545C-C motif chemokine. (93 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
RB1RB transcriptional corepressor 1. (957 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
Cdk4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
IL10RBInterleukin 10 receptor subunit beta. (334 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
GNA13G protein subunit alpha 13. (306 aa)
Pik3r2Uncharacterized protein. (724 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
E2F1E2F transcription factor 1. (392 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
NFATC4Nuclear factor of activated T cells 4. (890 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
Tap2Uncharacterized protein. (703 aa)
TAP1Transporter 1, ATP binding cassette subfamily B member. (749 aa)
TSC1TSC complex subunit 1. (1164 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (972 aa)
Casp3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
RHEBL1RHEB like 1. (183 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (874 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
RhoaRas homolog family member A. (193 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GNB4G protein subunit beta 4. (340 aa)
CREB3cAMP responsive element binding protein 3. (374 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
SP1Sp1 transcription factor. (788 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
RAC1Rac family small GTPase 1. (211 aa)
Eif4ebp1Uncharacterized protein. (118 aa)
PDIA3Protein disulfide-isomerase. (505 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
Gnao1G protein subunit alpha o1. (344 aa)
IL10RAInterleukin 10 receptor subunit alpha. (576 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
NFATC1Nuclear factor of activated T cells 1. (941 aa)
TBK1TANK binding kinase 1. (729 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
CALRCalreticulin. (418 aa)
LOC106144614Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
C7orf31Chromosome 7 open reading frame 31. (591 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
IL6RInterleukin 6 receptor. (409 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
E2F2E2F transcription factor 2. (432 aa)
Ptgs2EGF-like domain-containing protein. (605 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (522 aa)
ELK1ETS transcription factor ELK1. (428 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
GNB1G protein subunit beta 1. (340 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
TRADDTNFRSF1A associated via death domain. (302 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TSC2TSC complex subunit 2. (1745 aa)
CXCR2C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LOC101968597C-C motif chemokine. (92 aa)
LOC101968303C-C motif chemokine. (93 aa)
PTGER1Prostaglandin E receptor 1. (405 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
RAC3Rac family small GTPase 3. (185 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GNB5G protein subunit beta 5. (386 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (424 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
CALML4Calmodulin like 4. (153 aa)
I3MPY1_ICTTRIg-like domain-containing protein; Belongs to the MHC class I family. (349 aa)
GNB3G protein subunit beta 3. (340 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (77 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
CCL5C-C motif chemokine ligand 5. (91 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1518 aa)
CTNNB1Catenin beta 1. (781 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (148 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (442 aa)
Ppp3r1Uncharacterized protein. (169 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
PPP3CCSerine/threonine-protein phosphatase. (487 aa)
GNB2G protein subunit beta 2. (371 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
IL1R1Interleukin 1 receptor type 1. (506 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
GNAQG protein subunit alpha q. (313 aa)
LOC101966190Ig-like domain-containing protein; Belongs to the MHC class I family. (387 aa)
I3MUP6_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
I3MVH6_ICTTRIg-like domain-containing protein; Belongs to the MHC class I family. (370 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
CALML6Calmodulin like 6. (172 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
RAC2Rac family small GTPase 2. (192 aa)
LOC101956844Ig-like domain-containing protein; Belongs to the MHC class I family. (389 aa)
I3MXS4_ICTTRCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
I3MZ83_ICTTRIg-like domain-containing protein; Belongs to the MHC class I family. (342 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (361 aa)
STING1Transmembrane protein 173. (379 aa)
LOC101960206Uncharacterized protein. (207 aa)
IRF3Interferon regulatory factor 3. (420 aa)
LOC101959358Uncharacterized protein. (193 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
LOC101960961Calreticulin. (437 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (488 aa)
LOC101966768Ig-like domain-containing protein; Belongs to the MHC class I family. (362 aa)
I3N418_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
CCR5C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (351 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
RUFY4RUN and FYVE domain containing 4. (566 aa)
E2F3E2F transcription factor 3. (460 aa)
LOC101977967Ig-like domain-containing protein; Belongs to the MHC class I family. (351 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
LOC101976253Ig-like domain-containing protein; Belongs to the MHC class I family. (358 aa)
RhocUncharacterized protein. (193 aa)
JAK1Tyrosine-protein kinase. (1142 aa)
LOC101968765Uncharacterized protein. (187 aa)
LOC101961596Ig-like domain-containing protein. (242 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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