STRINGSTRING
LEF1 LEF1 ARAF ARAF Rhoa Rhoa MYC MYC MLH1 MLH1 EGFR EGFR RAC1 RAC1 MSH2 MSH2 DDB2 DDB2 BAD BAD AREG AREG LOC106144614 LOC106144614 C7orf31 C7orf31 MAP2K1 MAP2K1 KRAS KRAS LOC101962660 LOC101962660 TGFB1 TGFB1 SMAD3 SMAD3 AKT3 AKT3 Ralgds Ralgds TGFBR1 TGFBR1 AXIN1 AXIN1 MAPK8 MAPK8 GRB2 GRB2 PIK3CA PIK3CA CCND1 CCND1 EREG EREG MAPK3 MAPK3 RALB RALB TGFB2 TGFB2 PIK3CB PIK3CB MAPK10 MAPK10 Pik3r2 Pik3r2 Map2k2 Map2k2 BRAF BRAF AKT2 AKT2 FOS FOS EPGN EPGN DCC DCC SMAD2 SMAD2 Casp3 Casp3 BAX BAX RAC3 RAC3 MAPK1 MAPK1 APPL1 APPL1 CTNNB1 CTNNB1 LOC101965906 LOC101965906 TCF7 TCF7 NRAS NRAS BCL2 BCL2 GADD45G GADD45G MSH6 MSH6 RPS6KB2 RPS6KB2 SMAD4 SMAD4 RAC2 RAC2 I3MXS4_ICTTR I3MXS4_ICTTR PPP1R14B PPP1R14B MSH3 MSH3 GADD45B GADD45B LOC101959358 LOC101959358 TCF7L1 TCF7L1 CDKN1A CDKN1A RAF1 RAF1 TP53 TP53 Rhoc Rhoc AXIN2 AXIN2 Rps6kb1 Rps6kb1 ERAS ERAS BIRC5 BIRC5 GADD45A GADD45A JUN JUN I3NC87_ICTTR I3NC87_ICTTR I3NCK5_ICTTR I3NCK5_ICTTR TGFB3 TGFB3 RALA RALA BCL2L11 BCL2L11 GSK3B GSK3B TGFA TGFA LOC101968118 LOC101968118 TGFBR2 TGFBR2 ENSSTOP00000025685 ENSSTOP00000025685 LOC101973038 LOC101973038 PIK3R1 PIK3R1 ENSSTOP00000026081 ENSSTOP00000026081 ENSSTOP00000027174 ENSSTOP00000027174 APC2 APC2 LOC101975023 LOC101975023 Polk Polk AKT1 AKT1 HRAS HRAS Pik3r3 Pik3r3 BAK1 BAK1 Pik3cd Pik3cd SOS1 SOS1 MAPK9 MAPK9 ENSSTOP00000031001 ENSSTOP00000031001 Csde1 Csde1 ENSSTOP00000031310 ENSSTOP00000031310 LOC101978532 LOC101978532 TCF7L2 TCF7L2 APC APC MTOR MTOR ENSSTOP00000032525 ENSSTOP00000032525
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEF1Lymphoid enhancer binding factor 1. (399 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
RhoaRas homolog family member A. (193 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
MLH1MutL homolog 1. (758 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
RAC1Rac family small GTPase 1. (211 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
DDB2Damage specific DNA binding protein 2. (430 aa)
BADBCL2 associated agonist of cell death. (208 aa)
AREGAmphiregulin. (252 aa)
LOC106144614Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
C7orf31Chromosome 7 open reading frame 31. (591 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RalgdsUncharacterized protein. (894 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
AXIN1Axin 1. (869 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCND1Cyclin D1. (250 aa)
EREGEpiregulin. (163 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
RALBRAS like proto-oncogene B. (206 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Pik3r2Uncharacterized protein. (724 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
EPGNEpithelial mitogen. (153 aa)
DCCDCC netrin 1 receptor. (1447 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
Casp3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
RAC3Rac family small GTPase 3. (185 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (699 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
TCF7Transcription factor 7. (302 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1362 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RAC2Rac family small GTPase 2. (192 aa)
I3MXS4_ICTTRCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
MSH3MutS homolog 3. (1031 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
LOC101959358Uncharacterized protein. (193 aa)
TCF7L1Transcription factor 7 like 1. (557 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
RhocUncharacterized protein. (193 aa)
AXIN2Axin 2. (840 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ERASES cell expressed Ras. (227 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
I3NC87_ICTTRCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
I3NCK5_ICTTRCARD domain-containing protein. (102 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
RALARAS like proto-oncogene A. (206 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
TGFATransforming growth factor alpha. (159 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSSTOP00000025685Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (106 aa)
LOC101973038UmuC domain-containing protein. (265 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSSTOP00000026081Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSSTOP00000027174Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (101 aa)
APC2APC regulator of WNT signaling pathway 2. (2114 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
PolkUmuC domain-containing protein. (541 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
Pik3r3Uncharacterized protein. (461 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSSTOP00000031001Uncharacterized protein. (178 aa)
Csde1Uncharacterized protein. (555 aa)
ENSSTOP00000031310Uncharacterized protein; Belongs to the peptidase C14A family. (233 aa)
LOC101978532Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (100 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
APCAPC regulator of WNT signaling pathway. (2865 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
ENSSTOP00000032525Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (94 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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