STRINGSTRING
LOC101975023 LOC101975023 Polk Polk HRAS HRAS CCDC6 CCDC6 BAK1 BAK1 NCOA4 NCOA4 Csde1 Csde1 TCF7L2 TCF7L2 LEF1 LEF1 CDH1 CDH1 GADD45G GADD45G NRAS NRAS TCF7 TCF7 CTNNB1 CTNNB1 MAPK1 MAPK1 BAX BAX TPR TPR PPARG PPARG RXRG RXRG KRAS KRAS MAP2K1 MAP2K1 NTRK1 NTRK1 DDB2 DDB2 MYC MYC BRAF BRAF Map2k2 Map2k2 RET RET MAPK3 MAPK3 CCND1 CCND1 RXRA RXRA GADD45B GADD45B RXRB RXRB TCF7L1 TCF7L1 CDKN1A CDKN1A TP53 TP53 TFG TFG ERAS ERAS GADD45A GADD45A LOC101973038 LOC101973038 PAX8 PAX8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101975023CSD_1 domain-containing protein. (729 aa)
PolkUmuC domain-containing protein. (541 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CCDC6Coiled-coil domain containing 6. (476 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
NCOA4Nuclear receptor coactivator 4. (624 aa)
Csde1Uncharacterized protein. (555 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
TCF7Transcription factor 7. (302 aa)
CTNNB1Catenin beta 1. (781 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
TPRTranslocated promoter region, nuclear basket protein. (2435 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
RXRGRetinoid X receptor gamma. (463 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
NTRK1Tyrosine-protein kinase receptor. (799 aa)
DDB2Damage specific DNA binding protein 2. (430 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1112 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
CCND1Cyclin D1. (250 aa)
RXRARetinoid X receptor alpha. (461 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
RXRBRetinoid X receptor beta. (531 aa)
TCF7L1Transcription factor 7 like 1. (557 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
TFGTrafficking from ER to golgi regulator. (397 aa)
ERASES cell expressed Ras. (227 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
LOC101973038UmuC domain-containing protein. (265 aa)
PAX8Paired box 8. (574 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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