STRINGSTRING
GADD45B GADD45B LEF1 LEF1 APC APC TCF7L2 TCF7L2 PTCH1 PTCH1 FZD7 FZD7 BAK1 BAK1 Polk Polk APC2 APC2 LOC101973038 LOC101973038 DVL3 DVL3 GSK3B GSK3B GLI3 GLI3 FZD2 FZD2 FZD8 FZD8 SUFU SUFU WNT7B WNT7B FZD9 FZD9 GADD45A GADD45A WNT3A WNT3A WNT11 WNT11 WNT5A WNT5A WNT3 WNT3 AXIN2 AXIN2 GLI1 GLI1 TP53 TP53 CDKN1A CDKN1A WNT7A WNT7A BMP2 BMP2 TCF7L1 TCF7L1 AXIN1 AXIN1 WNT10A WNT10A WNT8B WNT8B WNT9B WNT9B KIF7 KIF7 FZD5 FZD5 GADD45G GADD45G FZD10 FZD10 FZD4 FZD4 TCF7 TCF7 SHH SHH CTNNB1 CTNNB1 BAX BAX KIF27 KIF27 FZD1 FZD1 DVL1 DVL1 WNT5B WNT5B WNT4 WNT4 BMP4 BMP4 WNT1 WNT1 WNT10B WNT10B GLI2 GLI2 WNT2 WNT2 PTCH2 PTCH2 WNT16 WNT16 WNT6 WNT6 HHIP HHIP WNT8A WNT8A DDB2 DDB2 FZD6 FZD6 WNT9A WNT9A DVL2 DVL2 FZD3 FZD3 SMO SMO WNT2B WNT2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
APCAPC regulator of WNT signaling pathway. (2865 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
PTCH1Patched 1. (1450 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (598 aa)
BAK1BCL2 antagonist/killer 1. (208 aa)
PolkUmuC domain-containing protein. (541 aa)
APC2APC regulator of WNT signaling pathway 2. (2114 aa)
LOC101973038UmuC domain-containing protein. (265 aa)
DVL3Dishevelled segment polarity protein 3. (717 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
GLI3GLI family zinc finger 3. (1582 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (556 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (470 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (488 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
AXIN2Axin 2. (840 aa)
GLI1GLI family zinc finger 1. (1107 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (336 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TCF7L1Transcription factor 7 like 1. (557 aa)
AXIN1Axin 1. (869 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1345 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
TCF7Transcription factor 7. (302 aa)
SHHSonic hedgehog signaling molecule. (370 aa)
CTNNB1Catenin beta 1. (781 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
KIF27Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1399 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (643 aa)
DVL1Dishevelled segment polarity protein 1. (696 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
GLI2GLI family zinc finger 2. (1540 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
PTCH2Patched 2. (1197 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
HHIPHedgehog interacting protein. (700 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
DDB2Damage specific DNA binding protein 2. (430 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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