STRINGSTRING
PER2 PER2 BCL2A1 BCL2A1 MAP2K1 MAP2K1 KRAS KRAS LOC101962660 LOC101962660 MPO MPO AKT3 AKT3 NFKB1 NFKB1 Spib Spib GRB2 GRB2 PIK3CA PIK3CA PML PML CSF2 CSF2 PIM2 PIM2 MAPK1 MAPK1 CHUK CHUK LOC101965906 LOC101965906 TCF7 TCF7 NRAS NRAS CD14 CD14 RPS6KB2 RPS6KB2 CSF1R CSF1R RELA RELA PPP1R14B PPP1R14B Cebpa Cebpa TCF7L1 TCF7L1 RAF1 RAF1 PIM1 PIM1 Rps6kb1 Rps6kb1 ERAS ERAS SPI1 SPI1 LOC101966442 LOC101966442 PPARD PPARD LOC101968118 LOC101968118 RARA RARA PIK3R1 PIK3R1 IKBKG IKBKG LOC101975023 LOC101975023 ENSSTOP00000028389 ENSSTOP00000028389 AKT1 AKT1 HRAS HRAS RUNX1T1 RUNX1T1 JUP JUP Pik3r3 Pik3r3 Pik3cd Pik3cd SOS1 SOS1 Csde1 Csde1 TCF7L2 TCF7L2 MTOR MTOR LEF1 LEF1 CCND1 CCND1 KIT KIT MAPK3 MAPK3 PIK3CB PIK3CB Pik3r2 Pik3r2 Map2k2 Map2k2 BRAF BRAF AKT2 AKT2 FLT3 FLT3 ITGAM ITGAM ZBTB16 ZBTB16 CCNA1 CCNA1 ARAF ARAF MYC MYC IKBKB IKBKB DUSP6 DUSP6 STAT5B STAT5B STAT5A STAT5A STAT3 STAT3 Eif4ebp1 Eif4ebp1 CEBPE CEBPE CCNA2 CCNA2 BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PER2Period circadian regulator 2. (1297 aa)
BCL2A1BCL2 related protein A1. (175 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
MPOMyeloperoxidase. (718 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
SpibETS domain-containing protein. (262 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PMLPromyelocytic leukemia. (877 aa)
CSF2Colony stimulating factor 2. (138 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (370 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
TCF7Transcription factor 7. (302 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
CebpaUncharacterized protein. (122 aa)
TCF7L1Transcription factor 7 like 1. (557 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ERASES cell expressed Ras. (227 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
LOC101966442Uncharacterized protein. (370 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
RARARetinoic acid receptor alpha. (462 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
ENSSTOP00000028389Uncharacterized protein. (113 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RUNX1T1RUNX1 partner transcriptional co-repressor 1. (604 aa)
JUPJunction plakoglobin. (780 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
Csde1Uncharacterized protein. (555 aa)
TCF7L2Transcription factor 7 like 2. (514 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
CCND1Cyclin D1. (250 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
Pik3r2Uncharacterized protein. (724 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (985 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1120 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
STAT5BSignal transducer and activator of transcription. (765 aa)
STAT5ASignal transducer and activator of transcription. (773 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
Eif4ebp1Uncharacterized protein. (118 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (420 aa)
BADBCL2 associated agonist of cell death. (208 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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