STRINGSTRING
LDHC LDHC Ldha Ldha HKDC1 HKDC1 KIT KIT MAPK3 MAPK3 PIK3CB PIK3CB RET RET Pik3r2 Pik3r2 PFKM PFKM Map2k2 Map2k2 HK2 HK2 IDH2 IDH2 GCK GCK TNIK TNIK AKT2 AKT2 FLT3 FLT3 ERBB2 ERBB2 FGFR2 FGFR2 HK3 HK3 Hif1a Hif1a MYC MYC PFKP PFKP PARP8 PARP8 EGFR EGFR NTRK1 NTRK1 PARP6 PARP6 PGAM2 PGAM2 SCO1 SCO1 MAP2K1 MAP2K1 KRAS KRAS LOC101962660 LOC101962660 SLC2A2 SLC2A2 AKT3 AKT3 PDGFRA PDGFRA PIK3CA PIK3CA MAPK1 MAPK1 SIRT3 SIRT3 PDHA1 PDHA1 SCO2 SCO2 LOC101965906 LOC101965906 Ldhb Ldhb NRAS NRAS PTEN PTEN TIGAR TIGAR GLS GLS MET MET SLC16A3 SLC16A3 TP53 TP53 PDHB PDHB Slc7a5 Slc7a5 G6PD G6PD ERAS ERAS PGAM1 PGAM1 SLC1A5 SLC1A5 PFKL PFKL PDGFRB PDGFRB LOC101975488 LOC101975488 LOC101968118 LOC101968118 SIRT6 SIRT6 PIK3R1 PIK3R1 FGFR1 FGFR1 SLC2A1 SLC2A1 ENSSTOP00000027444 ENSSTOP00000027444 LOC101975023 LOC101975023 AKT1 AKT1 HRAS HRAS NTRK3 NTRK3 PDK1 PDK1 Pik3r3 Pik3r3 Pik3cd Pik3cd PKM PKM Csde1 Csde1 GLS2 GLS2 IDH1 IDH1 MTOR MTOR HK1 HK1 FGFR3 FGFR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (323 aa)
LdhaL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1112 aa)
Pik3r2Uncharacterized protein. (724 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
HK2Hexokinase 2. (917 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
GCKPhosphotransferase. (467 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (985 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
FGFR2Fibroblast growth factor receptor. (823 aa)
HK3Hexokinase 3. (867 aa)
Hif1aUncharacterized protein. (821 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
PARP8Poly [ADP-ribose] polymerase. (893 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
NTRK1Tyrosine-protein kinase receptor. (799 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (305 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (521 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (257 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (260 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
LdhbL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (324 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
GLSGlutaminase. (669 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
SLC16A3Solute carrier family 16 member 3. (466 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
Slc7a5Uncharacterized protein. (448 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
ERASES cell expressed Ras. (227 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
SLC1A5Amino acid transporter. (537 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
LOC101975488Uncharacterized protein. (456 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
SIRT6Sirtuin 6. (351 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ENSSTOP00000027444Uncharacterized protein; Belongs to the LDH/MDH superfamily. (301 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
Csde1Uncharacterized protein. (555 aa)
GLS2Glutaminase 2. (602 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (413 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
HK1Hexokinase 1. (920 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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