STRINGSTRING
AKT3 AKT3 TIRAP TIRAP LOC101962660 LOC101962660 MAP2K3 MAP2K3 KRAS KRAS MAP2K1 MAP2K1 MAP3K3 MAP3K3 Csnk2a1 Csnk2a1 STAT1 STAT1 LTK LTK NFATC1 NFATC1 NFKBIA NFKBIA BATF3 BATF3 STAT3 STAT3 EGFR EGFR JAK2 JAK2 IKBKB IKBKB Hif1a Hif1a CSNK2A2 CSNK2A2 FOS FOS IFNGR2 IFNGR2 MAPK3 MAPK3 PIK3CB PIK3CB Pik3r2 Pik3r2 Map2k2 Map2k2 ALK ALK TRAF6 TRAF6 AKT2 AKT2 PRKCQ PRKCQ NFKBIB NFKBIB BATF BATF CD28 CD28 TLR4 TLR4 IFNGR1 IFNGR1 RELA RELA RPS6KB2 RPS6KB2 CD3D CD3D PDCD1 PDCD1 PTEN PTEN NRAS NRAS NFATC3 NFATC3 PPP3CC PPP3CC PPP3CB PPP3CB MTOR MTOR RASGRP1 RASGRP1 Csde1 Csde1 Ly6g5b Ly6g5b PTPN6 PTPN6 Pik3cd Pik3cd Pik3r3 Pik3r3 NFATC2 NFATC2 Tmed7 Tmed7 HRAS HRAS AKT1 AKT1 LOC101975023 LOC101975023 IKBKG IKBKG PIK3R1 PIK3R1 LAT LAT EML4 EML4 LOC101968118 LOC101968118 LOC101961439 LOC101961439 MAPK13 MAPK13 BATF2 BATF2 MAPK14 MAPK14 CD4 CD4 TLR2 TLR2 JUN JUN TICAM2 TICAM2 ERAS ERAS Rps6kb1 Rps6kb1 CD247 CD247 PTPN11 PTPN11 JAK1 JAK1 LOC101965906 LOC101965906 Ppp3r1 Ppp3r1 CHUK CHUK CD274 CD274 MAPK11 MAPK11 MAPK12 MAPK12 IFNG IFNG MAPK1 MAPK1 MYD88 MYD88 NFKBIE NFKBIE CSNK2B CSNK2B PIK3CA PIK3CA PPP3CA PPP3CA PLCG1 PLCG1 NFKB1 NFKB1 ZAP70 ZAP70
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TIRAPTIR domain containing adaptor protein. (222 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
Csnk2a1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
LTKTyrosine-protein kinase receptor. (576 aa)
NFATC1Nuclear factor of activated T cells 1. (941 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (122 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
Hif1aUncharacterized protein. (821 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (343 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
IFNGR2Interferon gamma receptor 2. (306 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
Pik3r2Uncharacterized protein. (724 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
ALKTyrosine-protein kinase receptor. (1612 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
NFKBIBNFKB inhibitor beta. (359 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
CD28CD28 molecule. (221 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
IFNGR1Interferon gamma receptor 1. (476 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
CD3DCD3d molecule. (170 aa)
PDCD1Programmed cell death 1. (288 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
PPP3CCSerine/threonine-protein phosphatase. (487 aa)
PPP3CBSerine/threonine-protein phosphatase. (523 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
Csde1Uncharacterized protein. (555 aa)
Ly6g5bUncharacterized protein. (195 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Pik3r3Uncharacterized protein. (461 aa)
NFATC2Nuclear factor of activated T cells 2. (844 aa)
Tmed7GOLD domain-containing protein. (225 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LATLinker for activation of T cells. (234 aa)
EML4EMAP like 4. (992 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
LOC101961439TIR domain-containing protein. (1051 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (274 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CD4CD4 molecule. (451 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
ERASES cell expressed Ras. (227 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CD247CD247 molecule. (144 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
JAK1Tyrosine-protein kinase. (1142 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
Ppp3r1Uncharacterized protein. (169 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
CD274CD274 molecule. (293 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (248 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
ZAP70Tyrosine-protein kinase. (608 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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