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CXCL8 CXCL8 ATP6V1G3 ATP6V1G3 HLA-DOB HLA-DOB HLA-DPA1 HLA-DPA1 HLA-DPB1 HLA-DPB1 ACP5 ACP5 I3M4W8_ICTTR I3M4W8_ICTTR ATP6V1C2 ATP6V1C2 IL15 IL15 CXCL12 CXCL12 ATP6V0A2 ATP6V0A2 ATP6V1B1 ATP6V1B1 LOC101967545 LOC101967545 ENSSTOP00000031595 ENSSTOP00000031595 LOC101970873 LOC101970873 TEK TEK CCL20 CCL20 ATP6V0A1 ATP6V0A1 ATP6AP1 ATP6AP1 CXCL6 CXCL6 ENSSTOP00000028111 ENSSTOP00000028111 ENSSTOP00000027636 ENSSTOP00000027636 ENSSTOP00000027396 ENSSTOP00000027396 TCIRG1 TCIRG1 TNFSF13 TNFSF13 Atp6v0e2 Atp6v0e2 ENSSTOP00000026281 ENSSTOP00000026281 ICAM1 ICAM1 Atp6v0c Atp6v0c ATP6V1H ATP6V1H LTB LTB ATP6V1D ATP6V1D ATP6V1B2 ATP6V1B2 LOC101968945 LOC101968945 TGFB3 TGFB3 LOC101969207 LOC101969207 TLR2 TLR2 JUN JUN LOC101959667 LOC101959667 TNFSF13B TNFSF13B LOC101957706 LOC101957706 ATP6V1C1 ATP6V1C1 CTLA4 CTLA4 ATP6V1G2 ATP6V1G2 LOC101957991 LOC101957991 CSF1 CSF1 PTH PTH TNFRSF11A TNFRSF11A LOC101960206 LOC101960206 CD28 CD28 LOC101964412 LOC101964412 FLT1 FLT1 I3N090_ICTTR I3N090_ICTTR ATP6V0E1 ATP6V0E1 TLR4 TLR4 ATP6V1E1 ATP6V1E1 I3MVL6_ICTTR I3MVL6_ICTTR LOC101955809 LOC101955809 RELCH RELCH IL18 IL18 I3MSG9_ICTTR I3MSG9_ICTTR ATP6V0D1 ATP6V0D1 LOC101970595 LOC101970595 IL23A IL23A ATP6V1G1 ATP6V1G1 CCL5 CCL5 Ctsl Ctsl IFNG IFNG ATP6V0D2 ATP6V0D2 ATP6V1F ATP6V1F CSF2 CSF2 CTSK CTSK LOC101954372 LOC101954372 LOC101968303 LOC101968303 TNF TNF HLA-DOA HLA-DOA HLA-DRA HLA-DRA TNFSF11 TNFSF11 TGFB1 TGFB1 LOC101968188 LOC101968188 LOC101968486 LOC101968486 HLA-DQB1 HLA-DQB1 ATP6V1A ATP6V1A HLA-DMA HLA-DMA VEGFA VEGFA MMP3 MMP3 MMP1 MMP1 IL17A IL17A Mmp10 Mmp10 ANGPT1 ANGPT1 CTSV CTSV IL11 IL11 TGFB2 TGFB2 ITGB2 ITGB2 ATP6V0A4 ATP6V0A4 IL1A IL1A IL1B IL1B ATP6V0B ATP6V0B Cd86 Cd86 ITGAL ITGAL FOS FOS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (282 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (288 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (327 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (134 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (817 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
LOC101967545C-C motif chemokine. (93 aa)
ENSSTOP00000031595V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (149 aa)
LOC101970873Ig-like domain-containing protein. (251 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
CCL20C-C motif chemokine ligand 20. (97 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (863 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
CXCL6C-X-C motif chemokine. (129 aa)
ENSSTOP00000028111Ig-like domain-containing protein. (135 aa)
ENSSTOP00000027636Ig-like domain-containing protein. (165 aa)
ENSSTOP00000027396V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (136 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (861 aa)
TNFSF13TNF superfamily member 13; Belongs to the tumor necrosis factor family. (250 aa)
Atp6v0e2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
ENSSTOP00000026281V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (151 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
Atp6v0cV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
LTBLymphotoxin beta; Belongs to the tumor necrosis factor family. (320 aa)
ATP6V1DUncharacterized protein. (131 aa)
ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
LOC101968945Uncharacterized protein; Belongs to the peptidase C1 family. (339 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC101969207C-C motif chemokine. (136 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
LOC101959667Ig-like domain-containing protein. (272 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (280 aa)
LOC101957706V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (191 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (226 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
LOC101957991Ig-like domain-containing protein. (249 aa)
CSF1Colony stimulating factor 1. (497 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. (115 aa)
TNFRSF11ATNF receptor superfamily member 11a. (625 aa)
LOC101960206Uncharacterized protein. (207 aa)
CD28CD28 molecule. (221 aa)
LOC101964412C-X-C motif chemokine. (102 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
ATP6V1E1ATPase H+ transporting V1 subunit E1. (226 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
LOC101955809Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1335 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
I3MSG9_ICTTRIg-like domain-containing protein. (186 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
LOC101970595Ig-like domain-containing protein. (264 aa)
IL23AInterleukin 23 subunit alpha. (185 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
CCL5C-C motif chemokine ligand 5. (91 aa)
CtslUncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
CSF2Colony stimulating factor 2. (138 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
LOC101954372C-X-C motif chemokine. (102 aa)
LOC101968303C-C motif chemokine. (93 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (220 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
LOC101968188Ig-like domain-containing protein. (266 aa)
LOC101968486Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (269 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (600 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (292 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
MMP3ZnMc domain-containing protein. (479 aa)
MMP1Matrix metallopeptidase 1. (449 aa)
IL17AInterleukin 17A. (154 aa)
Mmp10ZnMc domain-containing protein. (410 aa)
ANGPT1Angiopoietin 1. (497 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (332 aa)
IL11Interleukin 11. (199 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ITGB2Integrin beta. (769 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (837 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
Cd86Ig-like domain-containing protein. (289 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1149 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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