STRINGSTRING
MGST1 MGST1 NFE2L2 NFE2L2 NCF2 NCF2 MAPK7 MAPK7 EDN1 EDN1 ARHGEF2 ARHGEF2 BMP4 BMP4 PIK3CB PIK3CB MAPK10 MAPK10 Pik3r2 Pik3r2 IL1A IL1A IL1B IL1B BMPR2 BMPR2 Itgb3 Itgb3 AKT2 AKT2 FOS FOS LOC101964037 LOC101964037 PDGFA PDGFA I3M249_ICTTR I3M249_ICTTR LOC101958631 LOC101958631 ITGA2B ITGA2B MGST2 MGST2 Rhoa Rhoa ACVR1 ACVR1 NOX1 NOX1 HSP90B1 HSP90B1 IKBKB IKBKB CDH5 CDH5 MMP9 MMP9 NCF1 NCF1 GSTT4 GSTT4 RAC1 RAC1 Actg1 Actg1 LOC101960145 LOC101960145 CTSV CTSV SDC2 SDC2 CALML3 CALML3 I3MBE0_ICTTR I3MBE0_ICTTR IL1R2 IL1R2 VEGFA VEGFA SELE SELE MAP3K5 MAP3K5 SDC4 SDC4 HSP90AA1 HSP90AA1 PLAT PLAT LOC101962660 LOC101962660 TNFRSF1A TNFRSF1A KEAP1 KEAP1 ACTL9 ACTL9 MAP2K5 MAP2K5 PRKAA2 PRKAA2 Sumo3 Sumo3 AKT3 AKT3 NFKB1 NFKB1 LOC101963741 LOC101963741 PIAS4 PIAS4 GSTA4 GSTA4 LOC101964314 LOC101964314 MAPK8 MAPK8 TNF TNF PIK3CA PIK3CA CAV3 CAV3 GSTO1 GSTO1 GSTO2 GSTO2 RAC3 RAC3 Actb Actb ACVR2B ACVR2B IFNG IFNG BMPR1B BMPR1B MAPK12 MAPK12 MAPK11 MAPK11 Ctsl Ctsl CALML4 CALML4 BMPR1A BMPR1A NQO1 NQO1 CTNNB1 CTNNB1 KDR KDR CALM1 CALM1 CHUK CHUK DUSP1 DUSP1 LOC101965906 LOC101965906 IL1R1 IL1R1 CAV1 CAV1 LOC101959480 LOC101959480 GSTP1 GSTP1 BCL2 BCL2 CALML6 CALML6 ACTL7A ACTL7A LOC101975766 LOC101975766 ACTRT2 ACTRT2 MMP2 MMP2 GSTM3 GSTM3 ACVR2A ACVR2A RAC2 RAC2 MGST3 MGST3 LOC101954496 LOC101954496 RELA RELA LOC101958905 LOC101958905 LOC101971713 LOC101971713 ACTL8 ACTL8 GSTM2 GSTM2 PECAM1 PECAM1 LOC101959378 LOC101959378 MAP2K4 MAP2K4 LOC101959358 LOC101959358 Vcam1 Vcam1 NPPC NPPC ACTRT1 ACTRT1 ACTL7B ACTL7B PDGFB PDGFB TXN TXN LOC101970206 LOC101970206 TP53 TP53 Rhoc Rhoc GSTM4 GSTM4 ITGAV ITGAV PTTG1IP PTTG1IP JUN JUN I3NC62_ICTTR I3NC62_ICTTR I3NCC6_ICTTR I3NCC6_ICTTR HSP90AB1 HSP90AB1 LOC101969207 LOC101969207 CAV2 CAV2 LOC101959480-2 LOC101959480-2 LOC101958355 LOC101958355 MAPK14 MAPK14 SDC1 SDC1 CALM2 CALM2 LOC101975245 LOC101975245 LOC101968945 LOC101968945 Sumo2 Sumo2 MAPK13 MAPK13 NOXA1 NOXA1 PRKAA1 PRKAA1 TXN2 TXN2 CYBA CYBA LOC101968118 LOC101968118 TRPV4 TRPV4 MEF2A MEF2A ENSSTOP00000025413 ENSSTOP00000025413 ENSSTOP00000025853 ENSSTOP00000025853 PIK3R1 PIK3R1 ICAM1 ICAM1 HMOX1 HMOX1 IKBKG IKBKG CALM3 CALM3 ENSSTOP00000027334 ENSSTOP00000027334 ASS1 ASS1 AKT1 AKT1 Pik3r3 Pik3r3 Pik3cd Pik3cd ENSSTOP00000029812 ENSSTOP00000029812 ENSSTOP00000029937 ENSSTOP00000029937 ENSSTOP00000030397 ENSSTOP00000030397 MAP2K7 MAP2K7 MAPK9 MAPK9 NOS3 NOS3 MEF2C MEF2C LOC101964591 LOC101964591 ENSSTOP00000031001 ENSSTOP00000031001 PTK2 PTK2 Sumo1 Sumo1 ENSSTOP00000031475 ENSSTOP00000031475 ENSSTOP00000032237 ENSSTOP00000032237 ENSSTOP00000032378 ENSSTOP00000032378 MAP3K7 MAP3K7 SQSTM1 SQSTM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MGST1Microsomal glutathione S-transferase 1. (155 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (600 aa)
NCF2Neutrophil cytosolic factor 2. (525 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (812 aa)
EDN1Endothelin 1. (202 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (869 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Pik3r2Uncharacterized protein. (724 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
LOC101964037Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
I3M249_ICTTRUncharacterized protein. (683 aa)
LOC101958631Glutathione S-transferase. (222 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1036 aa)
MGST2Microsomal glutathione S-transferase 2. (153 aa)
RhoaRas homolog family member A. (193 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
NOX1NADPH oxidase 1. (561 aa)
HSP90B1Heat shock protein 90 beta family member 1. (805 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
MMP9Matrix metallopeptidase 9. (667 aa)
NCF1Neutrophil cytosolic factor 1. (405 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (240 aa)
RAC1Rac family small GTPase 1. (211 aa)
Actg1Uncharacterized protein. (375 aa)
LOC101960145Glutathione S-transferase. (218 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (332 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
I3MBE0_ICTTRSmall ubiquitin-related modifier. (111 aa)
IL1R2Interleukin 1 receptor type 2. (396 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
SELESelectin E. (495 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1307 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (176 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
KEAP1Kelch like ECH associated protein 1. (624 aa)
ACTL9Actin like 9; Belongs to the actin family. (415 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
Sumo3Small ubiquitin-related modifier. (102 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
LOC101963741Uncharacterized protein. (240 aa)
PIAS4Protein inhibitor of activated STAT 4. (472 aa)
GSTA4Glutathione S-transferase alpha 4. (222 aa)
LOC101964314Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (241 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (248 aa)
RAC3Rac family small GTPase 3. (185 aa)
ActbActin beta. (375 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
CtslUncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
CALML4Calmodulin like 4. (153 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (275 aa)
CTNNB1Catenin beta 1. (781 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (148 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
DUSP1Dual specificity phosphatase 1. (272 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
IL1R1Interleukin 1 receptor type 1. (506 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
LOC101959480Uncharacterized protein. (222 aa)
GSTP1Glutathione S-transferase pi 1. (210 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
CALML6Calmodulin like 6. (172 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
LOC101975766Uncharacterized protein. (152 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (435 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
GSTM3Glutathione S-transferase mu 3; Belongs to the GST superfamily. (225 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
RAC2Rac family small GTPase 2. (192 aa)
MGST3Microsomal glutathione S-transferase 3. (153 aa)
LOC101954496Uncharacterized protein. (346 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
LOC101958905Uncharacterized protein; Belongs to the GST superfamily. (221 aa)
LOC101971713Uncharacterized protein; Belongs to the actin family. (1238 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
GSTM2Uncharacterized protein; Belongs to the GST superfamily. (218 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (740 aa)
LOC101959378Uncharacterized protein; Belongs to the GST superfamily. (218 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
LOC101959358Uncharacterized protein. (193 aa)
Vcam1Vascular cell adhesion molecule 1. (657 aa)
NPPCNatriuretic peptide C. (126 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (377 aa)
ACTL7BActin like 7B; Belongs to the actin family. (418 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
LOC101970206Small ubiquitin-related modifier. (93 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (391 aa)
RhocUncharacterized protein. (193 aa)
GSTM4Glutathione S-transferase mu 4. (218 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1077 aa)
PTTG1IPPTTG1 interacting protein. (194 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
I3NC62_ICTTRUncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (355 aa)
I3NCC6_ICTTRUncharacterized protein; Belongs to the actin family. (340 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
LOC101969207C-C motif chemokine. (136 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
LOC101959480-2Uncharacterized protein; Belongs to the GST superfamily. (221 aa)
LOC101958355Uncharacterized protein. (222 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (311 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
LOC101975245HATPase_c domain-containing protein. (733 aa)
LOC101968945Uncharacterized protein; Belongs to the peptidase C1 family. (339 aa)
Sumo2Small ubiquitin-related modifier. (88 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
NOXA1NADPH oxidase activator 1. (492 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
TXN2Thioredoxin 2. (166 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
MEF2AMyocyte enhancer factor 2A. (496 aa)
ENSSTOP00000025413Uncharacterized protein. (72 aa)
ENSSTOP00000025853Uncharacterized protein. (42 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
HMOX1Heme oxygenase 1. (288 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
CALM3Calmodulin 3. (149 aa)
ENSSTOP00000027334Small ubiquitin-related modifier. (112 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ENSSTOP00000029812Small ubiquitin-related modifier. (112 aa)
ENSSTOP00000029937Uncharacterized protein; Belongs to the calmodulin family. (67 aa)
ENSSTOP00000030397Uncharacterized protein; Belongs to the actin family. (148 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LOC101964591Glutathione S-transferase theta-2B-like. (244 aa)
ENSSTOP00000031001Uncharacterized protein. (178 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
Sumo1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (101 aa)
ENSSTOP00000031475Uncharacterized protein; Belongs to the actin family. (173 aa)
ENSSTOP00000032237Uncharacterized protein; Belongs to the calmodulin family. (148 aa)
ENSSTOP00000032378Rad60-SLD domain-containing protein. (85 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
SQSTM1Sequestosome 1. (440 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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