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| | purA | PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | coaX | Predicted transcriptional regulator; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (259 aa) |
| | CKL_0268 | Histidinol-phosphatase-related protein; Belongs to the PHP hydrolase family. HisK subfamily. (277 aa) |
| | CKL_0327 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (93 aa) |
| | guaB | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | guaA | GuaA; Catalyzes the synthesis of GMP from XMP. (510 aa) |
| | lysC1 | LysC1; Aspartokinase; Belongs to the aspartokinase family. (399 aa) |
| | lysA | LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (431 aa) |
| | CKL_0636 | Conserved hypothetical protein. (270 aa) |
| | panB | PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (280 aa) |
| | panC | PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (292 aa) |
| | CKL_0639 | Predicted phosphatase. (281 aa) |
| | carA1 | CarA1; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (349 aa) |
| | carB1 | CarB1; Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1068 aa) |
| | CKL_0699 | Predicted aminotransferase. (543 aa) |
| | nadA | NadA; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (303 aa) |
| | nadB | NadB; Catalyzes the oxidation of L-aspartate to iminoaspartate. (529 aa) |
| | nadC | NadC; Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (276 aa) |
| | aroF | AroF; Phospho-2-dehydro-3-deoxyheptonate aldolase. (344 aa) |
| | tyrA | TyrA; Prephenate dehydrogenase. (290 aa) |
| | aroB | AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa) |
| | aroA | AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa) |
| | aroC | AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (360 aa) |
| | pheA | PheA; Predicted bifunctional chorismate mutase/ prephenate dehydratase. (379 aa) |
| | aroE1 | AroE1; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa) |
| | aroK | AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa) |
| | add | Add; Predicted adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (348 aa) |
| | pheB | PheB; Predicted phenylalanine biosynthesis protein; Belongs to the UPF0735 family. (145 aa) |
| | cdd | Cdd; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (138 aa) |
| | bioB1 | BioB1; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (241 aa) |
| | bioA | BioA; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (451 aa) |
| | folP | FolP; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (271 aa) |
| | folE | FolE; GTP cyclohydrolase I. (185 aa) |
| | CKL_0959 | Predicted hydrolase. (158 aa) |
| | CKL_0960 | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (296 aa) |
| | argG | ArgG; Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa) |
| | argH | ArgH; Argininosuccinate lyase. (438 aa) |
| | nadE | NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (638 aa) |
| | surE | SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (245 aa) |
| | aroD | AroD; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (255 aa) |
| | aroE2 | AroE2; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa) |
| | aroE3 | AroE3; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (289 aa) |
| | asnB | AsnB; Predicted asparagine synthetase. (613 aa) |
| | pyrP | PyrP; Predicted uracil permease. (430 aa) |
| | pyrR | PyrR; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (177 aa) |
| | dapF | DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | ppnK | PpnK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (283 aa) |
| | pdp | Pdp; Pyrimidine-nucleoside phosphorylase. (433 aa) |
| | trpE | TrpE; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (476 aa) |
| | trpG | TrpG; Anthranilate synthase component II. (194 aa) |
| | trpD | TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa) |
| | trpC | TrpC; Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | trpF | TrpF; N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa) |
| | trpB1 | TrpB1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | purL | PurL; Predicted phosphoribosylformylglycinamidine synthase. (1257 aa) |
| | hisZ | HisZ; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (391 aa) |
| | hisG | HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (219 aa) |
| | hisD | HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | hisC | HisC; Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa) |
| | hisB | HisB; Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisH | HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | hisA | HisA; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase. (238 aa) |
| | hisF | HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisI | HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (106 aa) |
| | hisE | HisE; phosphoribosyl-ATP pyrophosphatase. (105 aa) |
| | CKL_1303 | Predicted phosphatase. (217 aa) |
| | CKL_1304 | Hypothetical protein. (196 aa) |
| | hisK | HisK; Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (257 aa) |
| | coaBC | CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (397 aa) |
| | coaD | CoaD; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa) |
| | lysC2 | LysC2; Aspartokinase; Belongs to the aspartokinase family. (399 aa) |
| | purB | PurB; Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa) |
| | CKL_1467 | Predicted nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (493 aa) |
| | CKL_1474 | Conserved protein; Related to purH. (90 aa) |
| | CKL_1475 | Conserved protein; Related to purH. (202 aa) |
| | aspA1 | AspA1; Aspartate ammonia-lyase. (470 aa) |
| | argC | ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | argJ | ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa) |
| | argB | ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (283 aa) |
| | argD | ArgD; Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | punA | PunA; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa) |
| | panD | PanD; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa) |
| | bioB2 | BioB2; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (334 aa) |
| | ribH | RibH; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | ribAB | RibAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (400 aa) |
| | ribE | RibE; Riboflavin synthase alpha chain. (217 aa) |
| | ribD | RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (369 aa) |
| | asn | Asn; Predicted asparagine synthetase. (529 aa) |
| | aspA2 | AspA2; Aspartate ammonia-lyase. (465 aa) |
| | carB2 | CarB2; Carbamoyl-phosphate synthase large chain. (1072 aa) |
| | carA2 | CarA2; Carbamoyl-phosphate synthase large chain; Belongs to the CarA family. (354 aa) |
| | argF | ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (336 aa) |
| | CKL_2418 | Conserved hypothetical protein; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. Belongs to the peptidase M38 family. (388 aa) |
| | purD | PurD; Predicted phosphoribosylamine--glycine ligase; Belongs to the GARS family. (413 aa) |
| | purH | PurH; Predicted bifunctional purine biosynthesis protein purH. (499 aa) |
| | purN | PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa) |
| | purM | PurM; Phosphoribosylformylglycinamidine cyclo-ligase. (331 aa) |
| | purF | PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (483 aa) |
| | purC | PurC; Predicted phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (235 aa) |
| | purE | PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa) |
| | CKL_2693 | Predicted permease. (468 aa) |
| | dapB1 | DapB1; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (271 aa) |
| | gmk | Gmk; Predicted guanylate kinase. (185 aa) |
| | apt | Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa) |
| | CKL_3204 | Predicted aminotransferase. (386 aa) |
| | dapB2 | DapB2; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) |
| | dapA4 | DapA4; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | asd | Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (328 aa) |
| | dapD | DapD; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (238 aa) |
| | folC | FolC; Predicted folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (450 aa) |
| | pyrE | PyrE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (190 aa) |
| | pyrD2 | PyrD2; Catalyzes the conversion of dihydroorotate to orotate. (296 aa) |
| | pyrK | PyrK; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (258 aa) |
| | pyrF | PyrF; Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (291 aa) |
| | pyrC | PyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (393 aa) |
| | pyrI | PyrI; Aspartate carbamoyltransferase regulatory chain. (143 aa) |
| | pyrB | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa) |
| | cinA | Hypothetical protein; Belongs to the CinA family. (410 aa) |
| | CKL_3596 | Conserved hypothetical protein containing an uridine kinase domain. (571 aa) |
| | CKL_3642 | Predicted nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family. (280 aa) |
| | upp | Upp; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | npdA | NpdA; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (241 aa) |
| | CKL_3821 | Pyrophosphatase-related protein. (172 aa) |
