STRINGSTRING
purA purA guaB guaB guaA guaA carA1 carA1 carB1 carB1 surE surE pyrP pyrP pyrR pyrR purL purL purB purB CKL_1474 CKL_1474 CKL_1475 CKL_1475 carB2 carB2 carA2 carA2 CKL_2418 CKL_2418 purD purD purH purH purN purN purM purM purF purF purC purC purE purE CKL_2693 CKL_2693 gmk gmk apt apt pyrE pyrE pyrD2 pyrD2 pyrK pyrK pyrF pyrF pyrC pyrC pyrI pyrI pyrB pyrB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purAPurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
guaBGuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa)
guaAGuaA; Catalyzes the synthesis of GMP from XMP. (510 aa)
carA1CarA1; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (349 aa)
carB1CarB1; Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1068 aa)
surESurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (245 aa)
pyrPPyrP; Predicted uracil permease. (430 aa)
pyrRPyrR; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (177 aa)
purLPurL; Predicted phosphoribosylformylglycinamidine synthase. (1257 aa)
purBPurB; Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa)
CKL_1474Conserved protein; Related to purH. (90 aa)
CKL_1475Conserved protein; Related to purH. (202 aa)
carB2CarB2; Carbamoyl-phosphate synthase large chain. (1072 aa)
carA2CarA2; Carbamoyl-phosphate synthase large chain; Belongs to the CarA family. (354 aa)
CKL_2418Conserved hypothetical protein; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. Belongs to the peptidase M38 family. (388 aa)
purDPurD; Predicted phosphoribosylamine--glycine ligase; Belongs to the GARS family. (413 aa)
purHPurH; Predicted bifunctional purine biosynthesis protein purH. (499 aa)
purNPurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa)
purMPurM; Phosphoribosylformylglycinamidine cyclo-ligase. (331 aa)
purFPurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (483 aa)
purCPurC; Predicted phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (235 aa)
purEPurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa)
CKL_2693Predicted permease. (468 aa)
gmkGmk; Predicted guanylate kinase. (185 aa)
aptApt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
pyrEPyrE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (190 aa)
pyrD2PyrD2; Catalyzes the conversion of dihydroorotate to orotate. (296 aa)
pyrKPyrK; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (258 aa)
pyrFPyrF; Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (291 aa)
pyrCPyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (393 aa)
pyrIPyrI; Aspartate carbamoyltransferase regulatory chain. (143 aa)
pyrBPyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
Your Current Organism:
Clostridium kluyveri
NCBI taxonomy Id: 431943
Other names: C. kluyveri DSM 555, Clostridium kluyveri DSM 555, Clostridium kluyveri str. DSM 555, Clostridium kluyveri strain DSM 555
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.