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ecfA ecfA ecfA-2 ecfA-2 ecfT ecfT CKL_0526 CKL_0526 hemA hemA hemL hemL CKL_0696 CKL_0696 hemB hemB cobD1 cobD1 cobO cobO cbiG cbiG CKL_0717 CKL_0717 hemC hemC hemD hemD cbiK cbiK cbiP cbiP cbiB cbiB cbiC cbiC cbiD cbiD cbiE cbiE cbiT cbiT cbiL cbiL cbiF cbiF cbiJ cbiJ cbiH cbiH cobU cobU cobC2 cobC2 CKL_0755 CKL_0755 CKL_0801 CKL_0801 CKL_0802 CKL_0802 CKL_0803 CKL_0803 CKL_0804 CKL_0804 CKL_0807 CKL_0807 CKL_0808 CKL_0808 iscS iscS thiI thiI CKL_0827 CKL_0827 CKL_0828 CKL_0828 CKL_0829 CKL_0829 CKL_0830 CKL_0830 sufS sufS nifU1 nifU1 CKL_0933 CKL_0933 CKL_0936 CKL_0936 oppA1 oppA1 oppB oppB oppC oppC oppD oppD oppF oppF CKL_1057 CKL_1057 CKL_1058 CKL_1058 CKL_1059 CKL_1059 nifS1 nifS1 trmU trmU CKL_1311 CKL_1311 CKL_1312 CKL_1312 CKL_1313 CKL_1313 CKL_1314 CKL_1314 CKL_1315 CKL_1315 CKL_1317 CKL_1317 nifS2 nifS2 nifU2 nifU2 CKL_1320 CKL_1320 CKL_1321 CKL_1321 CKL_1322 CKL_1322 CKL_1323 CKL_1323 CKL_1687 CKL_1687 CKL_1688 CKL_1688 cysN cysN cysD cysD CKL_1797 CKL_1797 aprA aprA cysC cysC cysA cysA cysW cysW cysT cysT sbpA sbpA CKL_1805 CKL_1805 CKL_1806 CKL_1806 CKL_1807 CKL_1807 CKL_2033 CKL_2033 CKL_2037 CKL_2037 CKL_2038 CKL_2038 CKL_2201 CKL_2201 CKL_2202 CKL_2202 CKL_2203 CKL_2203 CKL_2248 CKL_2248 CKL_2497 CKL_2497 CKL_2498 CKL_2498 CKL_2499 CKL_2499 cobT cobT sirC sirC cobD2 cobD2 CKL_3111 CKL_3111 cobS cobS cbiO cbiO cbiQ cbiQ cbiN cbiN cbiM cbiM oppA2 oppA2 CKL_3469 CKL_3469 CKL_3608 CKL_3608 CKL_3609 CKL_3609 CKL_3610 CKL_3610 CKL_3611 CKL_3611
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ecfAPredicted transporter protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (281 aa)
ecfA-2Predicted transporter protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (284 aa)
ecfTPredicted transporter protein; Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (270 aa)
CKL_0526Predicted cysteine synthase. (94 aa)
hemAHemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (415 aa)
hemLHemL; Glutamate-1-semialdehyde 2,1-aminomutase. (422 aa)
CKL_0696Cysteine desulfurase-related enzyme. (436 aa)
hemBHemB; Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (322 aa)
cobD1CobD1; Predicted threonine-phosphate decarboxylase. (355 aa)
cobOCobO; cob(I)yrinic acid a,c-diamide adenosyltransferase. (179 aa)
cbiGCbiG; Cobalamin biosynthesis protein CbiG. (332 aa)
CKL_0717PduX-related protein. (288 aa)
hemCHemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (305 aa)
hemDHemD; Porphyrin biosynthesis protein HemD. (490 aa)
cbiKCbiK; Sirohydrochlorin cobaltochelatase. (286 aa)
cbiPCbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (499 aa)
cbiBCbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (440 aa)
cbiCCbiC; precorrin-8X methylmutase. (208 aa)
cbiDCbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (365 aa)
cbiECbiE; precorrin-6Y C(5)-methyltransferase. (204 aa)
cbiTCbiT; precorrin-6Y C(15)-methyltransferase. (186 aa)
cbiLCbiL; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. (221 aa)
cbiFCbiF; Precorrin-4 C(11)-methyltransferase. (251 aa)
cbiJCbiJ; precorrin-6A reductase. (262 aa)
cbiHCbiH; precorrin-3B C(17)-methyltransferase. (239 aa)
cobUCobU; Bifunctional adenosylcobalamin biosynthesis protein CobU. (185 aa)
cobC2CobC2; Alpha-ribazole phosphatase; Belongs to the phosphoglycerate mutase family. (193 aa)
CKL_0755Conserved hypothetical protein. (185 aa)
CKL_0801Conserved hypothetical protein. (131 aa)
CKL_0802Hypothetical protein. (59 aa)
CKL_0803Conserved hypothetical protein. (144 aa)
CKL_0804Predicted transporter protein. (171 aa)
CKL_0807Conserved hypothetical protein. (197 aa)
CKL_0808Conserved hypothetical protein. (319 aa)
iscSIscS; Cysteine desulfurase. (378 aa)
thiIThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (381 aa)
CKL_0827Conserved hypothetical protein. (68 aa)
CKL_0828Predicted SufC. (248 aa)
CKL_0829Predicted SufB. (468 aa)
CKL_0830Predicted SufD. (384 aa)
sufSSufS; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (420 aa)
nifU1NifU1; NifU-like protein. (146 aa)
CKL_0933Anaerobic sulfite reductase-related protein. (229 aa)
CKL_0936Predicted biotin synthesis protein. (185 aa)
oppA1OppA1; Oligopeptide ABC transporter, extracellular solute-binding protein. (539 aa)
oppBOppB; Oligopeptide ABC transporter, permease protein. (312 aa)
oppCOppC; Oligopeptide ABC transporter, permease protein. (300 aa)
oppDOppD; Oligopeptide ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily. (321 aa)
oppFOppF; Oligopeptide ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily. (322 aa)
CKL_1057Conserved hypothetical protein. (211 aa)
CKL_1058Conserved hypothetical protein. (185 aa)
CKL_1059Conserved hypothetical protein. (578 aa)
nifS1NifS1; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (389 aa)
trmUTrmU; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (356 aa)
CKL_1311Hypothetical protein. (529 aa)
CKL_1312Hypothetical protein. (334 aa)
CKL_1313Hypothetical protein. (293 aa)
CKL_1314Hypothetical protein; Belongs to the ABC transporter superfamily. (318 aa)
CKL_1315Hypothetical protein. (250 aa)
CKL_1317Transcriptional regulator. (148 aa)
nifS2NifS2; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (402 aa)
nifU2NifU2; NifU-like protein. (143 aa)
CKL_1320Conserved hypothetical protein. (167 aa)
CKL_1321Predicted permease. (341 aa)
CKL_1322Hypothetical protein. (223 aa)
CKL_1323Conserved hypothetical protein. (449 aa)
CKL_1687Predicted phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (94 aa)
CKL_1688Predicted phosphoglycerate mutase. (74 aa)
cysNCysN; Sulfate adenylyltransferase. (610 aa)
cysDCysD; Sulfate adenylyltransferase. (266 aa)
CKL_1797Hypothetical protein. (105 aa)
aprAAprA; Adenylylsulfate reductase. (563 aa)
cysCCysC; Catalyzes the synthesis of activated sulfate. (199 aa)
cysACysA; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family. (352 aa)
cysWCysW; Sulfate transport system permease protein. (275 aa)
cysTCysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. (272 aa)
sbpASbpA; Sulfate-binding protein. (351 aa)
CKL_1805Hypothetical protein. (276 aa)
CKL_1806Hypothetical protein. (136 aa)
CKL_1807Hypothetical protein; Belongs to the sulfur carrier protein TusA family. (771 aa)
CKL_2033Conserved hypothetical protein. (250 aa)
CKL_2037Conserved hypothetical protein. (213 aa)
CKL_2038Conserved hypothetical protein. (210 aa)
CKL_2201Conserved hypothetical protein. (220 aa)
CKL_2202Hypothetical protein. (163 aa)
CKL_2203Hypothetical protein. (94 aa)
CKL_2248Conserved hypothetical protein. (181 aa)
CKL_2497Predicted ABC transporter, ATPase component. (263 aa)
CKL_2498Predicted permease. (265 aa)
CKL_2499Hypothetical protein. (338 aa)
cobTCobT; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (360 aa)
sirCSirC; Predicted precorrin-2 dehydrogenase. (208 aa)
cobD2CobD2; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (325 aa)
CKL_3111Conserved hypothetical protein; Belongs to the TtcA family. (299 aa)
cobSHypothetical protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (252 aa)
cbiOCbiO; Part of an ABC transporter complex. Responsible for energy coupling to the transport system. (277 aa)
cbiQCbiQ; Predicted cobalt transport protein. (262 aa)
cbiNCbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (105 aa)
cbiMCbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (246 aa)
oppA2OppA2; Predicted oligopeptide-binding protein oppA precursor. (538 aa)
CKL_3469Conserved hypothetical protein. (74 aa)
CKL_3608Predicted phosphohydrolase. (228 aa)
CKL_3609Conserved hypothetical protein. (88 aa)
CKL_3610Conserved hypothetical protein. (556 aa)
CKL_3611Conserved hypothetical protein; Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins; Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family. (208 aa)
Your Current Organism:
Clostridium kluyveri
NCBI taxonomy Id: 431943
Other names: C. kluyveri DSM 555, Clostridium kluyveri DSM 555, Clostridium kluyveri str. DSM 555, Clostridium kluyveri strain DSM 555
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