(12 nodes) Cobalamin metabolic process network (Clostridium kluyveri)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cbiG	CbiG; Cobalamin biosynthesis protein CbiG. (332 aa)
	cbiK	CbiK; Sirohydrochlorin cobaltochelatase. (286 aa)
	cbiP	CbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (499 aa)
	cbiB	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (440 aa)
	cbiC	CbiC; precorrin-8X methylmutase. (208 aa)
	cbiD	CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (365 aa)
	cbiE	CbiE; precorrin-6Y C(5)-methyltransferase. (204 aa)
	cbiT	CbiT; precorrin-6Y C(15)-methyltransferase. (186 aa)
	cbiL	CbiL; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. (221 aa)
	cbiF	CbiF; Precorrin-4 C(11)-methyltransferase. (251 aa)
	cbiJ	CbiJ; precorrin-6A reductase. (262 aa)
	cbiH	CbiH; precorrin-3B C(17)-methyltransferase. (239 aa)

Your Current Organism:

Clostridium kluyveri

NCBI taxonomy Id: 431943
Other names: C. kluyveri DSM 555, Clostridium kluyveri DSM 555, Clostridium kluyveri str. DSM 555, Clostridium kluyveri strain DSM 555

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cbiB	cbiC	CKL_0722	CKL_0723	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiC; precorrin-8X methylmutase.	0.999
cbiB	cbiD	CKL_0722	CKL_0724	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.	0.987
cbiB	cbiE	CKL_0722	CKL_0725	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiE; precorrin-6Y C(5)-methyltransferase.	0.969
cbiB	cbiF	CKL_0722	CKL_0728	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiF; Precorrin-4 C(11)-methyltransferase.	0.993
cbiB	cbiG	CKL_0722	CKL_0716	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiG; Cobalamin biosynthesis protein CbiG.	0.974
cbiB	cbiH	CKL_0722	CKL_0730	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiH; precorrin-3B C(17)-methyltransferase.	0.980
cbiB	cbiJ	CKL_0722	CKL_0729	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiJ; precorrin-6A reductase.	0.970
cbiB	cbiK	CKL_0722	CKL_0720	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiK; Sirohydrochlorin cobaltochelatase.	0.975
cbiB	cbiL	CKL_0722	CKL_0727	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiL; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway.	0.971
cbiB	cbiP	CKL_0722	CKL_0721	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	0.996
cbiB	cbiT	CKL_0722	CKL_0726	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiT; precorrin-6Y C(15)-methyltransferase.	0.986
cbiC	cbiB	CKL_0723	CKL_0722	CbiC; precorrin-8X methylmutase.	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	0.999
cbiC	cbiD	CKL_0723	CKL_0724	CbiC; precorrin-8X methylmutase.	CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.	0.993
cbiC	cbiE	CKL_0723	CKL_0725	CbiC; precorrin-8X methylmutase.	CbiE; precorrin-6Y C(5)-methyltransferase.	0.999
cbiC	cbiF	CKL_0723	CKL_0728	CbiC; precorrin-8X methylmutase.	CbiF; Precorrin-4 C(11)-methyltransferase.	0.999
cbiC	cbiG	CKL_0723	CKL_0716	CbiC; precorrin-8X methylmutase.	CbiG; Cobalamin biosynthesis protein CbiG.	0.985
cbiC	cbiH	CKL_0723	CKL_0730	CbiC; precorrin-8X methylmutase.	CbiH; precorrin-3B C(17)-methyltransferase.	0.998
cbiC	cbiJ	CKL_0723	CKL_0729	CbiC; precorrin-8X methylmutase.	CbiJ; precorrin-6A reductase.	0.998
cbiC	cbiK	CKL_0723	CKL_0720	CbiC; precorrin-8X methylmutase.	CbiK; Sirohydrochlorin cobaltochelatase.	0.973
cbiC	cbiL	CKL_0723	CKL_0727	CbiC; precorrin-8X methylmutase.	CbiL; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway.	0.998