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| | lysS | LysS; lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (502 aa) |
| | asnS | AsnS; asparaginyl-tRNA synthetase. (463 aa) |
| | accA | AccA; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (281 aa) |
| | accD | AccD; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa) |
| | accC | AccC; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | fabZ | FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (150 aa) |
| | accB | AccB; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (170 aa) |
| | fabF | FabF; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa) |
| | fabG1 | FabG1; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | fabD | FabD; malonyl-CoA-acyl carrier protein transacylase. (312 aa) |
| | acp1 | Acp1; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (75 aa) |
| | fabH1 | FabH1; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (323 aa) |
| | CKL_0089 | Predicted flavoprotein. (409 aa) |
| | CKL_0088 | Predicted acyl-acyl carrier protein thioesterase. (249 aa) |
| | ppsA | PpsA; Predicted phosphoenolpyruvate synthase. (877 aa) |
| | leuA1 | LeuA1; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (553 aa) |
| | serS | SerS; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | glyS | GlyS; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (463 aa) |
| | ispD | IspD; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (231 aa) |
| | cysS | CysS; cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (465 aa) |
| | CKL_0268 | Histidinol-phosphatase-related protein; Belongs to the PHP hydrolase family. HisK subfamily. (277 aa) |
| | mutE | MutE; Methylaspartate mutase, subunit E. (430 aa) |
| | glmS | GlmS; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (608 aa) |
| | proC1 | ProC1; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa) |
| | algI | AlgI; Predicted poly(beta-D-mannuronate) O-acetylase; Belongs to the membrane-bound acyltransferase family. (473 aa) |
| | CKL_0395 | Conserved hypothetical protein. (401 aa) |
| | CKL_0410 | Conserved hypothetical protein. (152 aa) |
| | CKL_0423 | 2-hydroxyglutaryl-CoA dehydratase activator-related protein. (254 aa) |
| | ilvE1 | IlvE1; Predicted threonine dehydratase. (412 aa) |
| | serA | SerA; Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa) |
| | folD | FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | pyc | Pyc; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1146 aa) |
| | crt1 | Crt1; 3-hydroxybutyryl-CoA dehydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (259 aa) |
| | bcd | Bcd; butyryl-CoA dehydrogenase. (379 aa) |
| | hbd1 | Hbd1; 3-hydroxybutyryl-CoA dehydrogenase. (282 aa) |
| | CKL_0460 | Glutamate synthase-related protein. (463 aa) |
| | guaA | GuaA; Catalyzes the synthesis of GMP from XMP. (510 aa) |
| | CKL_0486 | GMP synthase. (45 aa) |
| | CKL_0509 | Predicted pyridoxal-phosphate dependent deaminase. (329 aa) |
| | CKL_0526 | Predicted cysteine synthase. (94 aa) |
| | idh | Idh; Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (401 aa) |
| | CKL_0547 | Conserved hypothetical protein. (188 aa) |
| | CKL_0563 | Zn-dependent dehydrogenase. (364 aa) |
| | proS | ProS; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (476 aa) |
| | lysC1 | LysC1; Aspartokinase; Belongs to the aspartokinase family. (399 aa) |
| | lysA | LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (431 aa) |
| | trpS | TrpS; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (341 aa) |
| | CKL_0616 | Conserved hypothetical protein; Belongs to the UPF0597 family. (418 aa) |
| | CKL_0628 | Conserved hypothetical protein. (119 aa) |
| | CKL_0633 | Acyl-CoA dehydrogenase, short-chain specific. (562 aa) |
| | panB | PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (280 aa) |
| | panC | PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (292 aa) |
| | carA1 | CarA1; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (349 aa) |
| | carB1 | CarB1; Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1068 aa) |
| | amaA | AmaA; N-acyl-L-amino acid amidohydrolase. (398 aa) |
| | ald | Ald; Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (371 aa) |
| | CKL_0696 | Cysteine desulfurase-related enzyme. (436 aa) |
| | thrC | ThrC; Threonine synthase. (496 aa) |
| | CKL_0710 | Predicted iron-sulfur cluster-binding protein. (647 aa) |
| | cbiP | CbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (499 aa) |
| | cbiB | CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (440 aa) |
| | CKL_0738 | RocB-related protein. (551 aa) |
| | nadA | NadA; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (303 aa) |
| | nadC | NadC; Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (276 aa) |
| | tyrS1 | TyrS1; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (406 aa) |
| | CKL_0765 | Conserved hypothetical protein. (547 aa) |
| | CKL_0767 | N-dimethylarginine dimethylaminohydrolase-related protein. (283 aa) |
| | aroF | AroF; Phospho-2-dehydro-3-deoxyheptonate aldolase. (344 aa) |
| | tyrA | TyrA; Prephenate dehydrogenase. (290 aa) |
| | aroB | AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa) |
| | aroA | AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa) |
| | aroC | AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (360 aa) |
| | pheA | PheA; Predicted bifunctional chorismate mutase/ prephenate dehydratase. (379 aa) |
| | aroE1 | AroE1; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa) |
| | aroK | AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa) |
| | sufS | SufS; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (420 aa) |
| | CKL_0848 | Hypothetical protein. (316 aa) |
| | hom1 | Hom1; Homoserine dehydrogenase. (413 aa) |
| | thrB | ThrB; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa) |
| | ppdK | PpdK; Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (880 aa) |
| | gyaR | GyaR; Predicted glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | proB2 | ProB2; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (268 aa) |
| | CKL_0926 | Conserved hypothetical protein. (220 aa) |
| | bioB1 | BioB1; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (241 aa) |
| | bioA | BioA; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (451 aa) |
| | folP | FolP; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (271 aa) |
| | CKL_0960 | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (296 aa) |
| | CKL_0973 | 2-isopropylmalate synthase-related protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with oxaloacetate to form citrate. This enzyme is highly Re-face stereospecific with respect to the C-2 of oxaloacetate. (453 aa) |
| | CKL_0975 | O-acetyl-L-homoserine sulfhydrylase-related protein. (426 aa) |
| | metH1 | MetH1; Predicted methionine synthase. (801 aa) |
| | argG | ArgG; Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa) |
| | argH | ArgH; Argininosuccinate lyase. (438 aa) |
| | CKL_0985 | Asparaginyl-tRNA synthetase-related protein. (324 aa) |
| | metB1 | MetB1; Cystathione gamma-synthase. (382 aa) |
| | cysK | CysK; Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | aroD | AroD; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (255 aa) |
| | aroE2 | AroE2; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa) |
| | aroE3 | AroE3; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (289 aa) |
| | glnS | GlnS; glutaminyl-tRNA synthetase. (556 aa) |
| | asnB | AsnB; Predicted asparagine synthetase. (613 aa) |
| | nifB1 | NifB1; FeMo cofactor biosynthesis protein NifB. (423 aa) |
| | ilvC1 | IlvC1; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | ilvB1 | IlvB1; Predicted acetolactate synthase, large subunit. (553 aa) |
| | nifS1 | NifS1; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (389 aa) |
| | ilvC2 | IlvC2; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | hom2 | Hom2; Homoserine dehydrogenase. (433 aa) |
| | CKL_1145 | Predicted hydrolase. (244 aa) |
| | CKL_1197 | Predicted nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | dapF | DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | argR | Transcriptional regulator; Regulates arginine biosynthesis genes. (150 aa) |
| | trpD | TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa) |
| | trpC | TrpC; Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | trpF | TrpF; N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa) |
| | trpB1 | TrpB1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | glyA | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa) |
| | hisZ | HisZ; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (391 aa) |
| | hisG | HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (219 aa) |
| | hisD | HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | hisC | HisC; Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa) |
| | hisB | HisB; Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisH | HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | hisA | HisA; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase. (238 aa) |
| | hisF | HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisI | HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (106 aa) |
| | hisE | HisE; phosphoribosyl-ATP pyrophosphatase. (105 aa) |
| | hisK | HisK; Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (257 aa) |
| | nifS2 | NifS2; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (402 aa) |
| | alaS | AlaS; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (879 aa) |
| | coaBC | CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (397 aa) |
| | ldh | Hypothetical protein; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (315 aa) |
| | pta | Pta; Phosphotransacetylase. (333 aa) |
| | ackA | AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (405 aa) |
| | plsX | Hypothetical protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (334 aa) |
| | acpP | Hypothetical protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa) |
| | dxr | Dxr; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (385 aa) |
| | ispG | IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (349 aa) |
| | lysC2 | LysC2; Aspartokinase; Belongs to the aspartokinase family. (399 aa) |
| | gluS | GluS; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (487 aa) |
| | CKL_1480 | Predicted amidohydrolase. (390 aa) |
| | CKL_1514 | Conserved hypothetical protein. (98 aa) |
| | CKL_1515 | Conserved hypothetical protein. (115 aa) |
| | CKL_1525 | Predicted nonribosomal peptide synthetase; Belongs to the ATP-dependent AMP-binding enzyme family. (1895 aa) |
| | CKL_1527 | Predicted polyketide synthase. (3072 aa) |
| | argS | ArgS; arginyl-tRNA synthetase. (566 aa) |
| | CKL_1551 | Conserved hypothetical protein. (241 aa) |
| | argC | ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | argJ | ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa) |
| | argB | ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (283 aa) |
| | argD | ArgD; Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | CKL_1565 | Conserved hypothetical protein. (412 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase-related protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (637 aa) |
| | CKL_1585 | (R)-2-hydroxyglutaryl-CoA dehydratase activator-related protein. (319 aa) |
| | metA1 | MetA1; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (309 aa) |
| | ilvH | IlvH; Acetolactate synthase, small subunit. (165 aa) |
| | ilvI | IlvI; Acetolactate synthase, large subunit. (536 aa) |
| | gltD | GltD; Glutamate synthase, small subunit. (477 aa) |
| | gltB | GltB; Glutamate synthase, large subunit. (1509 aa) |
| | panD | PanD; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa) |
| | metA2 | MetA2; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (304 aa) |
| | metB2 | MetB2; Cystathionine gamma-synthase. (393 aa) |
| | CKL_1648 | Conserved hypothetical protein. (359 aa) |
| | CKL_1654 | Phosphoenolpyruvate synthase-related protein. (772 aa) |
| | ilvD | IlvD; Predicted dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (556 aa) |
| | bioB2 | BioB2; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (334 aa) |
| | CKL_1705 | Conserved hypothetical protein. (353 aa) |
| | CKL_1732 | Predicted PKS acyltransferase domain. (424 aa) |
| | nifB2 | NifB2; FeMo cofactor biosynthesis protein. (448 aa) |
| | CKL_1756 | FeMo cofactor biosynthesis-related protein. (209 aa) |
| | nifV1 | NifV1; Homocitrate synthase, alpha subunit; Belongs to the alpha-IPM synthase/homocitrate synthase family. (269 aa) |
| | nifV2 | NifV2; Homocitrate synthase, omega subunit. (353 aa) |
| | metH2 | MetH2; Predicted methionine synthase. (590 aa) |
| | metE | MetE; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (762 aa) |
| | lplA | LplA; Lipoate-protein ligase A. (330 aa) |
| | gcvPB | GcvPB; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (487 aa) |
| | gcvPA | GcvPA; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (439 aa) |
| | gcvH | GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | gcvT | GcvT; The glycine cleavage system catalyzes the degradation of glycine. (362 aa) |
| | CKL_1782 | Predicted FAD/FMN-containing dehydrogenase. (460 aa) |
| | CKL_1808 | O-acetyl-L-homoserine sulfhydrylase. (409 aa) |
| | CKL_1828 | Hypothetical protein. (213 aa) |
| | CKL_2037 | Conserved hypothetical protein. (213 aa) |
| | CKL_2056 | Hypothetical protein. (258 aa) |
| | CKL_2063 | Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | CKL_2064 | Hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | rkpK | RkpK; UDP-glucose 6-dehydrogenase. (444 aa) |
| | CKL_2101 | Conserved hypothetical protein. (401 aa) |
| | ilvB2 | IlvB2; Acetolactate synthase, large subunit. (569 aa) |
| | ilvE2 | IlvE2; Predicted branched-chain-amino-acid aminotransferase. (277 aa) |
| | CKL_2136 | Predicted hydrolase. (213 aa) |
| | leuB | LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (354 aa) |
| | leuD | LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa) |
| | leuC | LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa) |
| | leuA2 | LeuA2; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa) |
| | CKL_2178 | O-acetyl-L-homoserine sulfhydrylase-related protein. (442 aa) |
| | CKL_2180 | O-acetyl-L-homoserine sulfhydrylase-related protein. (432 aa) |
| | CKL_2184 | Methionine synthase-related protein. (378 aa) |
| | CKL_2185 | Methionine synthase-related protein. (372 aa) |
| | CKL_2187 | O-acetyl-L-homoserine sulfhydrylase-related protein. (428 aa) |
| | CKL_2196 | Conserved hypothetical protein. (283 aa) |
| | dfrD | DfrD; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
| | CKL_2208 | Predicted 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa) |
| | ppk | Ppk; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (716 aa) |
| | CKL_2259 | Predicted homocysteine S-methyltransferase. (313 aa) |
| | pdhC | PdhC; Dihydrolipoyllysine-residue acetyltransferase (E2 component of pyruvatedehydrogenase complex). (444 aa) |
| | pdhB | PdhB; Pyruvate dehydrogenase E1 component, beta subunit. (323 aa) |
| | pdhA | PdhA; Pyruvate dehydrogenase E1 component, alpha subunit. (333 aa) |
| | lipA2 | LipA2; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (287 aa) |
| | asn | Asn; Predicted asparagine synthetase. (529 aa) |
| | CKL_2324 | Predicted 3-oxoacyl-[acyl-carrier-protein] synthase. (227 aa) |
| | CKL_2348 | Phosphatase-related protein. (630 aa) |
| | CKL_2356 | Predicted PKS acyl carrier. (421 aa) |
| | carB2 | CarB2; Carbamoyl-phosphate synthase large chain. (1072 aa) |
| | carA2 | CarA2; Carbamoyl-phosphate synthase large chain; Belongs to the CarA family. (354 aa) |
| | argF | ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (336 aa) |
| | CKL_2378 | Conserved hypothetical protein. (301 aa) |
| | CKL_2400 | Conserved hypothetical protein. (107 aa) |
| | CKL_2404 | Predicted aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa) |
| | pdxT | PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (188 aa) |
| | CKL_2471 | Hypothetical protein. (315 aa) |
| | crt2 | Crt2; 3-hydroxybutyryl-CoA dehydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) |
| | CKL_2541 | Conserved hypothetical protein. (336 aa) |
| | CKL_2546 | Conserved hypothetical protein. (408 aa) |
| | CKL_2570 | Phosphoenolpyruvate synthase-related protein. (286 aa) |
| | CKL_2571 | Phosphoenolpyruvate synthase-related protein. (405 aa) |
| | CKL_2599 | Conserved hypothetical protein. (252 aa) |
| | CKL_2664 | Conserved hypothetical protein. (107 aa) |
| | CKL_2674 | Phosphatase-related protein. (377 aa) |
| | CKL_2677 | Phosphatase-related protein. (226 aa) |
| | purF | PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (483 aa) |
| | CKL_2701 | Cobyric acid synthase-related protein. (243 aa) |
| | CKL_2705 | Predicted metal-dependent hydrolase. (215 aa) |
| | CKL_2707 | Conserved hypothetical protein. (210 aa) |
| | ltaA | LtaA; L-allo-threonine aldolase. (342 aa) |
| | proA | ProA; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | proB1 | ProB1; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (272 aa) |
| | proC2 | ProC2; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (283 aa) |
| | hbd2 | Hbd2; Predicted 3-hydroxybutyryl-CoA dehydrogenase. (319 aa) |
| | dapB1 | DapB1; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (271 aa) |
| | CKL_2838 | Predicted hydrolase. (283 aa) |
| | aroH | AroH; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (342 aa) |
| | porB | PorB; Pyruvate:ferredoxin oxidoreductase. (310 aa) |
| | porD | PorD; Pyruvate:ferredoxin oxidoreductase. (99 aa) |
| | cat1 | Cat1; Forms succinyl-CoA from succinate and acetyl-CoA; Belongs to the acetyl-CoA hydrolase/transferase family. (538 aa) |
| | cat2 | Cat2; 4-hydroxybutyrate coenzyme A transferase; Belongs to the acetyl-CoA hydrolase/transferase family. (429 aa) |
| | abfD | AbfD; 4-hydroxybutyryl-CoA dehydratase. (484 aa) |
| | CKL_3022 | Predicted acyl dehydratase. (139 aa) |
| | acp2 | Acp2; Acyl carrier protein. (80 aa) |
| | gdh | Gdh; NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (443 aa) |
| | trpB2 | TrpB2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (460 aa) |
| | gabT | GabT; 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (458 aa) |
| | aspS | AspS; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (590 aa) |
| | hisS | HisS; histidyl-tRNA synthetase. (416 aa) |
| | dtd | Dtd; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (149 aa) |
| | pheT | PheT; phenylalanyl-tRNA synthetase, subunit B; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (792 aa) |
| | pheS | PheS; phenylalanyl-tRNA synthetase, subunit A; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (339 aa) |
| | thrS | ThrS; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (637 aa) |
| | dapB2 | DapB2; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) |
| | dapA4 | DapA4; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | asd | Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (328 aa) |
| | dapD | DapD; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (238 aa) |
| | valS | ValS; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (882 aa) |
| | pyrB | PyrB; Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa) |
| | eno | Hypothetical protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | gpmI | Hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa) |
| | tpiA | Hypothetical protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | pgk | Hypothetical protein; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | CKL_3412 | Hypothetical protein. (218 aa) |
| | CKL_3413 | Hypothetical protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | CKL_3422 | Hypothetical protein. (211 aa) |
| | pgi | Pgi; Glucose-6-phosphate isomerase; Belongs to the GPI family. (449 aa) |
| | fabH2 | FabH2; Predicted 3-oxoacyl-synthase. (328 aa) |
| | CKL_3515 | Predicted FAD/FMN-containing dehydrogenase. (468 aa) |
| | CKL_3524 | Conserved hypothetical protein. (223 aa) |
| | tyrS2 | TyrS2; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (402 aa) |
| | ispF | IspF; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (164 aa) |
| | CKL_3816 | Predicted phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (310 aa) |
| | pyk | Pyk; Pyruvate kinase; Belongs to the pyruvate kinase family. (585 aa) |
| | pfk1 | Pfk1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (318 aa) |
| | alr | Alr; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (391 aa) |
| | acpS | AcpS; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (134 aa) |
| | cat3 | Cat3; butyryl-CoA: acetate CoA transferase. (437 aa) |
| | leuS | LeuS; leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (811 aa) |
| | ilvE3 | IlvE3; Branched-chain amino acid aminotransferase. (344 aa) |
| | CKL_3641 | Predicted hydrolase. (292 aa) |
| | CKL_3647 | Conserved hypothetical protein. (119 aa) |
| | thlA1 | ThlA1; acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | thlA2 | ThlA2; acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | thlA3 | ThlA3; acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | pyrG | PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa) |
| | ispE | IspE; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (280 aa) |
| | CKL_3749 | Phosphoenolpyruvate synthase-related protein. (874 aa) |
| | ileS | IleS; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1034 aa) |
| | CKL_3754 | Predicted hydrolase. (210 aa) |
| | metS | MetS; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (644 aa) |
