STRINGSTRING
coaBC coaBC CKL_1467 CKL_1467 CKL_1490 CKL_1490 asn asn carB2 carB2 carA2 carA2 birA birA purC purC purM purM purD purD purA purA accC accC glnA glnA murC murC tilS tilS murD murD queC queC fhs fhs guaA guaA CKL_0486 CKL_0486 panC panC carA1 carA1 carB1 carB1 cbiB cbiB CKL_0848 CKL_0848 CKL_0909 CKL_0909 bioB1 bioB1 argG argG nadE nadE asnB asnB murE murE murF murF purL purL tmcAL tmcAL cphA cphA pyrG pyrG gatC gatC gatA gatA gatB gatB folC folC CKL_3213 CKL_3213 ddl ddl CKL_2701 CKL_2701 CKL_2700 CKL_2700
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
coaBCCoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (397 aa)
CKL_1467Predicted nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (493 aa)
CKL_14905-formyltetrahydrofolate cyclo-ligase-related protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (181 aa)
asnAsn; Predicted asparagine synthetase. (529 aa)
carB2CarB2; Carbamoyl-phosphate synthase large chain. (1072 aa)
carA2CarA2; Carbamoyl-phosphate synthase large chain; Belongs to the CarA family. (354 aa)
birABifunctional BirA-related protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (328 aa)
purCPurC; Predicted phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (235 aa)
purMPurM; Phosphoribosylformylglycinamidine cyclo-ligase. (331 aa)
purDPurD; Predicted phosphoribosylamine--glycine ligase; Belongs to the GARS family. (413 aa)
purAPurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
accCAccC; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
glnAGlnA; Predicted glutamine synthetase. (632 aa)
murCMurC; Cell wall formation; Belongs to the MurCDEF family. (457 aa)
tilSTilS; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (462 aa)
murDMurD; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (458 aa)
queCPredicted transcriptional regulator; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (226 aa)
fhsFhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (558 aa)
guaAGuaA; Catalyzes the synthesis of GMP from XMP. (510 aa)
CKL_0486GMP synthase. (45 aa)
panCPanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (292 aa)
carA1CarA1; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (349 aa)
carB1CarB1; Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1068 aa)
cbiBCbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (440 aa)
CKL_0848Hypothetical protein. (316 aa)
CKL_0909Conserved hypothetical protein. (101 aa)
bioB1BioB1; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (241 aa)
argGArgG; Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa)
nadENadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (638 aa)
asnBAsnB; Predicted asparagine synthetase. (613 aa)
murEMurE; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (485 aa)
murFMurF; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (463 aa)
purLPurL; Predicted phosphoribosylformylglycinamidine synthase. (1257 aa)
tmcALHypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (408 aa)
cphACphA; Cyanophycin synthetase; Belongs to the MurCDEF family. (874 aa)
pyrGPyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
gatCGatC; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (95 aa)
gatAGatA; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (491 aa)
gatBGatB; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (476 aa)
folCFolC; Predicted folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (450 aa)
CKL_3213Conserved hypothetical protein. (162 aa)
ddlDdl; Cell wall formation. (297 aa)
CKL_2701Cobyric acid synthase-related protein. (243 aa)
CKL_2700Conserved hypothetical protein. (453 aa)
Your Current Organism:
Clostridium kluyveri
NCBI taxonomy Id: 431943
Other names: C. kluyveri DSM 555, Clostridium kluyveri DSM 555, Clostridium kluyveri str. DSM 555, Clostridium kluyveri strain DSM 555
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