STRINGSTRING
dnaA dnaA recF recF CKL_0036 CKL_0036 CKL_0068 CKL_0068 CKL_0072 CKL_0072 CKL_0073 CKL_0073 purA purA CKL_0098 CKL_0098 CKL_0121 CKL_0121 mfd mfd ftsH1 ftsH1 fusA1 fusA1 clpC clpC radA radA tuf1 tuf1 fusA2 fusA2 adk adk ecfA ecfA ecfA-2 ecfA-2 CKL_0284 CKL_0284 CKL_0290 CKL_0290 CKL_0364 CKL_0364 CKL_0367 CKL_0367 CKL_0368 CKL_0368 CKL_0384 CKL_0384 CKL_0393 CKL_0393 CKL_0427 CKL_0427 dbpA dbpA fhs fhs CKL_0452 CKL_0452 CKL_0480 CKL_0480 CKL_0503 CKL_0503 CKL_0522 CKL_0522 CKL_0523 CKL_0523 stc stc CKL_0555 CKL_0555 ftsH2 ftsH2 CKL_0604 CKL_0604 CKL_0619 CKL_0619 CKL_0624 CKL_0624 CKL_0626 CKL_0626 CKL_0627 CKL_0627 CKL_0642 CKL_0642 metN metN coaE coaE addA addA cobO cobO cbiP cbiP cbiB cbiB cobU cobU prfC prfC CKL_0761 CKL_0761 proV proV aroK aroK CKL_0813 CKL_0813 CKL_0814 CKL_0814 CKL_0822 CKL_0822 CKL_0828 CKL_0828 minD minD obg obg CKL_0893 CKL_0893 lepA lepA era era CKL_0929 CKL_0929 bioB1 bioB1 feoB1 feoB1 CKL_0964 CKL_0964 CKL_0980 CKL_0980 addB addB CKL_1026 CKL_1026 CKL_1032 CKL_1032 nifH1 nifH1 CKL_1039 CKL_1039 nifH2 nifH2 oppD oppD oppF oppF exeE1 exeE1 fliI fliI flhF flhF fleN fleN CKL_1179 CKL_1179 ychF ychF exeE2 exeE2 CKL_1218 CKL_1218 recN recN CKL_1287 CKL_1287 CKL_1309 CKL_1309 CKL_1314 CKL_1314 CKL_1315 CKL_1315 CKL_1330 CKL_1330 pilT pilT pstB pstB der der CKL_1362 CKL_1362 gmk-2 gmk-2 priA priA rsgA rsgA recG recG smc smc ftsY ftsY ffh ffh CKL_1408 CKL_1408 CKL_1411 CKL_1411 infB infB ftsK ftsK recA recA CKL_1468 CKL_1468 kdpD kdpD hprK hprK CKL_1512 CKL_1512 CKL_1513 CKL_1513 CKL_1517 CKL_1517 CKL_1521 CKL_1521 cmk cmk mutS mutS miaA miaA feoB2 feoB2 CKL_1645 CKL_1645 CKL_1661 CKL_1661 CKL_1663 CKL_1663 CKL_1668 CKL_1668 CKL_1670 CKL_1670 CKL_1684 CKL_1684 CKL_1692 CKL_1692 CKL_1707 CKL_1707 vnfH vnfH CKL_1765 CKL_1765 CKL_1783 CKL_1783 CKL_1784 CKL_1784 cysN cysN cysC cysC cysA cysA CKL_1870 CKL_1870 CKL_1872 CKL_1872 CKL_1892 CKL_1892 CKL_2069 CKL_2069 CKL_2071 CKL_2071 CKL_2154 CKL_2154 CKL_2171 CKL_2171 CKL_2172 CKL_2172 CKL_2174 CKL_2174 CKL_2193 CKL_2193 CKL_2272 CKL_2272 CKL_2291 CKL_2291 CKL_2300 CKL_2300 CKL_2321 CKL_2321 CKL_2329 CKL_2329 hydF hydF clpA clpA CKL_2359 CKL_2359 CKL_2362 CKL_2362 recQ recQ CKL_2392 CKL_2392 CKL_2439 CKL_2439 CKL_2445 CKL_2445 CKL_2446 CKL_2446 CKL_2452 CKL_2452 CKL_2453 CKL_2453 CKL_2457 CKL_2457 nifH3 nifH3 CKL_2487 CKL_2487 CKL_2491 CKL_2491 CKL_2497 CKL_2497 CKL_2507 CKL_2507 CKL_2529 CKL_2529 CKL_2537 CKL_2537 CKL_2559 CKL_2559 CKL_2565 CKL_2565 CKL_2566 CKL_2566 CKL_2596 CKL_2596 CKL_2611 CKL_2611 CKL_2618 CKL_2618 CKL_2643 CKL_2643 CKL_2656 CKL_2656 CKL_2658 CKL_2658 clpB clpB ftsH3 ftsH3 livF livF livG livG CKL_2754 CKL_2754 potA potA CKL_2797 CKL_2797 CKL_2808 CKL_2808 CKL_2816 CKL_2816 CKL_2818 CKL_2818 gmk gmk CKL_2905 CKL_2905 CKL_2924 CKL_2924 CKL_2948 CKL_2948 CKL_3011 CKL_3011 CKL_3021 CKL_3021 CKL_3042 CKL_3042 CKL_3047 CKL_3047 CKL_3054 CKL_3054 CKL_3058 CKL_3058 nifH4 nifH4 CKL_3085 CKL_3085 ruvB ruvB hflX hflX mutS2 mutS2 CKL_3236 CKL_3236 CKL_3240 CKL_3240 CKL_3241 CKL_3241 CKL_3280 CKL_3280 CKL_3324 CKL_3324 CKL_3331 CKL_3331 engB engB lon lon clpX clpX CKL_3392 CKL_3392 CKL_3416 CKL_3416 CKL_3420 CKL_3420 cbiO cbiO CKL_3438 CKL_3438 pcrA pcrA CKL_3511 CKL_3511 CKL_3521 CKL_3521 CKL_3534 CKL_3534 CKL_3538 CKL_3538 CKL_3542 CKL_3542 CKL_3552 CKL_3552 CKL_3564 CKL_3564 uvrA uvrA uvrB uvrB ftsE ftsE CKL_3596 CKL_3596 CKL_3614 CKL_3614 secA secA CKL_3648 CKL_3648 CKL_3649 CKL_3649 CKL_3651 CKL_3651 recD2 recD2 atpD atpD atpA atpA rho rho pyrG pyrG CKL_3734 CKL_3734 CKL_3735 CKL_3735 CKL_3747 CKL_3747 CKL_3793 CKL_3793 tmk tmk dnaX dnaX CKL_3835 CKL_3835 CKL_3847 CKL_3847 CKL_3852 CKL_3852 CKL_3861 CKL_3861 CKL_3876 CKL_3876 CKL_3888 CKL_3888 CKL_3889 CKL_3889 CKL_3902 CKL_3902 CKL_3903 CKL_3903 parA parA trmE trmE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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dnaADnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (451 aa)
recFRecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (364 aa)
CKL_0036Predicted ABC transporter; ATPase component. (241 aa)
CKL_0068Conserved hypothetical protein. (78 aa)
CKL_0072Predicted transport protein; ATPase and permease component. (583 aa)
CKL_0073Predicted transport protein; ATPase and permease component. (607 aa)
purAPurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa)
CKL_0098DnaC-related protein. (328 aa)
CKL_0121Predicted exonuclease, sbcC related. (1164 aa)
mfdMfd; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1173 aa)
ftsH1FtsH1; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (600 aa)
fusA1FusA1; Elongation factor G. (696 aa)
clpCClpC; Predicted ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. (812 aa)
radARadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (451 aa)
tuf1Tuf1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (397 aa)
fusA2FusA2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (688 aa)
adkAdk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
ecfAPredicted transporter protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (281 aa)
ecfA-2Predicted transporter protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (284 aa)
CKL_0284Conserved hypothetical protein. (787 aa)
CKL_0290Plasmid transfer factor-related protein. (610 aa)
CKL_0364Predicted ABC transporter, ATPase component. (262 aa)
CKL_0367Predicted transport protein, ATPase and permease component. (599 aa)
CKL_0368Predicted transport protein, ATPase and permease component. (581 aa)
CKL_0384Predicted ABC transporter, ATPase component. (281 aa)
CKL_0393Predicted ABC transporter, ATPase component. (222 aa)
CKL_0427Predicted nucleotide-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (283 aa)
dbpAPredicted ATP-dependent RNA helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. (481 aa)
fhsFhs; Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (558 aa)
CKL_0452Predicted ABC transporter with duplicated ATPase domain. (636 aa)
CKL_0480Conserved hypothetical protein. (521 aa)
CKL_0503Predicted GTPase. (70 aa)
CKL_0522Predicted nickel binding GTPase. (229 aa)
CKL_0523Predicted ABC transporter, ATPase component. (268 aa)
stcStc; Signal-transduction and transcriptional-control protein. (632 aa)
CKL_0555MutS-related protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (629 aa)
ftsH2FtsH2; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (609 aa)
CKL_0604Predicted ATP-dependent DNA helicase. (709 aa)
CKL_0619Predicted ABC transporter, ATPase component. (265 aa)
CKL_0624Predicted nucleotide-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (278 aa)
CKL_0626Predicted ATP-binding protein containing a ferredoxin domain. (276 aa)
CKL_0627Predicted ATP-binding protein containing a ferredoxin domain. (299 aa)
CKL_0642Predicted serine kinase. (640 aa)
metNPredicted ABC transporter, ATPase component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (318 aa)
coaECoaE; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa)
addAPredicted ATP-dependent exonuclease; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily. (1235 aa)
cobOCobO; cob(I)yrinic acid a,c-diamide adenosyltransferase. (179 aa)
cbiPCbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (499 aa)
cbiBCbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (440 aa)
cobUCobU; Bifunctional adenosylcobalamin biosynthesis protein CobU. (185 aa)
prfCPrfC; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (530 aa)
CKL_0761Predicted ATP-binding protein. (151 aa)
proVProV; Predicted glycine betaine/L-proline transporter, ATP-binding protein. (394 aa)
aroKAroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa)
CKL_0813Predicted transport protein, ATPase and permease component. (600 aa)
CKL_0814Predicted transport protein, ATPase and permease component. (557 aa)
CKL_0822Predicted ABC transporter, ATPase component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. (259 aa)
CKL_0828Predicted SufC. (248 aa)
minDMinD; Septum site-determining protein MinD. (265 aa)
obgPredicted GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (424 aa)
CKL_0893Conserved hypothetical protein. (344 aa)
lepALepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (602 aa)
eraPredicted GTP-binding protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (293 aa)
CKL_0929Predicted ATP-binding protein. (244 aa)
bioB1BioB1; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (241 aa)
feoB1FeoB1; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. (705 aa)
CKL_0964Predicted ABC transporter, ATPase component. (303 aa)
CKL_0980Amino acid ABC transporter, ATP-binding protein. (259 aa)
addBAddB; ATP-dependent DNA helicase; Belongs to the helicase family. AddB/RexB type 1 subfamily. (1150 aa)
CKL_1026Conserved hypothetical protein. (458 aa)
CKL_1032Predicted transport protein, ATPase and permease component. (582 aa)
nifH1NifH1; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (272 aa)
CKL_1039Predicted ABC transporter, ATP-binding protein. (276 aa)
nifH2NifH2; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (272 aa)
oppDOppD; Oligopeptide ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily. (321 aa)
oppFOppF; Oligopeptide ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily. (322 aa)
exeE1ExeE1; Predicted general secretion pathway protein E. (557 aa)
fliIFliI; Flagellum-specific ATP synthase. (439 aa)
flhFFlhF; Flagellar biosynthesis protein FlhF. (397 aa)
fleNFleN; Flagellar synthesis regulator FleN. (291 aa)
CKL_1179Protease La-related protein. (770 aa)
ychFPredicted GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (365 aa)
exeE2ExeE2; Predicted general secretion pathway protein E. (498 aa)
CKL_1218Predicted stage III sporulation protein AA. (305 aa)
recNRecN; May be involved in recombinational repair of damaged DNA. (565 aa)
CKL_1287Predicted ABC transporter, ATPase component. (235 aa)
CKL_1309Predicted helicase subunit of Holliday junction resolvase. (437 aa)
CKL_1314Hypothetical protein; Belongs to the ABC transporter superfamily. (318 aa)
CKL_1315Hypothetical protein. (250 aa)
CKL_1330GTP-binding protein. (607 aa)
pilTPilT; Predicted twitching motility protein. (351 aa)
pstBPstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (249 aa)
derHypothetical protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (438 aa)
CKL_1362Hypothetical protein; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. (492 aa)
gmk-2Hypothetical protein; Essential for recycling GMP and indirectly, cGMP. (221 aa)
priAHypothetical protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (733 aa)
rsgAPredicted GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (287 aa)
recGHypothetical protein; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (679 aa)
smcHypothetical protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1183 aa)
ftsYFtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (303 aa)
ffhHypothetical protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (449 aa)
CKL_1408Predicted GTP-binding protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (280 aa)
CKL_1411Conserved hypothetical protein. (505 aa)
infBInfB; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (694 aa)
ftsKFtsK; DNA translocase. (763 aa)
recARecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (363 aa)
CKL_1468ATP-dependent DNA helicase. (670 aa)
kdpDKdpD; Sensor kinase. (898 aa)
hprKHprK; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, f [...] (308 aa)
CKL_1512Predicted transport protein, ATPase and permease component. (580 aa)
CKL_1513Predicted transport protein, ATPase and permease component. (580 aa)
CKL_1517Predicted transporter. (488 aa)
CKL_1521Predicted ABC transporter, ATPase component. (262 aa)
cmkCmk; Predicted cytidylate kinase. (221 aa)
mutSMutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (871 aa)
miaAMiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (309 aa)
feoB2FeoB2; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. (715 aa)
CKL_1645Predicted ABC transporter, ATPase component. (224 aa)
CKL_1661Predicted ABC transporter, ATPase component. (225 aa)
CKL_1663Conserved hypothetical protein. (425 aa)
CKL_1668Conserved hypothetical protein. (483 aa)
CKL_1670Conserved hypothetical protein. (392 aa)
CKL_1684Predicted ABC transporter, ATPase component. (309 aa)
CKL_1692Predicted ABC transporter with duplicated ATPase domain. (529 aa)
CKL_1707Predicted ABC transporter, ATPase component. (261 aa)
vnfHVnfH; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (275 aa)
CKL_1765Conserved hypothetical protein with LexA domain; Represses a number of genes involved in the response to DNA damage (SOS response); Belongs to the helicase family. UvrD subfamily. (815 aa)
CKL_1783Predicted transport protein, ATPase and permease component. (616 aa)
CKL_1784Predicted transport protein. (741 aa)
cysNCysN; Sulfate adenylyltransferase. (610 aa)
cysCCysC; Catalyzes the synthesis of activated sulfate. (199 aa)
cysACysA; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family. (352 aa)
CKL_1870Putative terminase large subunit. (423 aa)
CKL_1872Conserved hypothetical protein. (660 aa)
CKL_1892Predicted replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (447 aa)
CKL_2069Hypothetical protein. (255 aa)
CKL_2071Hypothetical protein. (556 aa)
CKL_2154Hypothetical protein; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family. (679 aa)
CKL_2171Predicted transport protein, ATPase and permease component. (601 aa)
CKL_2172Predicted transport protein. (572 aa)
CKL_2174Predicted ABC transporter, ATP-binding protein. (266 aa)
CKL_2193Predicted ABC transporter, ATPase component. (303 aa)
CKL_2272Predicted transcriptional regulator. (656 aa)
CKL_2291Predicted ABC transporter, ATPase component. (232 aa)
CKL_2300Predicted transporter protein. (295 aa)
CKL_2321Predicted ABC transporter, ATPase component. (308 aa)
CKL_2329Predicted ABC transporter with duplicated ATPase domain. (539 aa)
hydFHydF; Hydrogenase maturation protein HydF. (413 aa)
clpAClpA homolog protein; Belongs to the ClpA/ClpB family. (746 aa)
CKL_2359Predicted ABC transporter, ATPase component. (232 aa)
CKL_2362Predicted ABC transporter, ATPase component. (233 aa)
recQRecQ; Predicted ATP-dependent DNA helicase. (719 aa)
CKL_2392Predicted ABC transporter, ATPase component. (203 aa)
CKL_2439Predicted ABC transporter, ATPase component. (203 aa)
CKL_2445Predicted transport protein, ATPase and permease component. (582 aa)
CKL_2446Predicted transport protein, ATPase and permease component. (586 aa)
CKL_2452Conserved hypothetical protein. (556 aa)
CKL_2453Conserved hypothetical protein. (322 aa)
CKL_2457Conserved hypothetical protein. (571 aa)
nifH3NifH3; Nitrogenase iron protein; Belongs to the NifH/BchL/ChlL family. (251 aa)
CKL_2487Predicted ABC transporter, ATPase component. (304 aa)
CKL_2491Predicted ABC transporter, ATPase component. (241 aa)
CKL_2497Predicted ABC transporter, ATPase component. (263 aa)
CKL_2507Predicted ABC transporter, ATP-binding protein. (266 aa)
CKL_2529Predicted helicase. (747 aa)
CKL_2537Predicted transport protein. (453 aa)
CKL_2559Predicted helicase. (968 aa)
CKL_2565Hypothetical protein. (621 aa)
CKL_2566Hypothetical protein. (395 aa)
CKL_2596Type I restriction enzyme, endonuclease subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1069 aa)
CKL_2611Predicted ABC transporter, ATPase component. (206 aa)
CKL_2618Predicted ABC transporter, ATPase component. (487 aa)
CKL_2643Phage terminase. (544 aa)
CKL_2656Predicted Phage-related DNA helicase. (453 aa)
CKL_2658Phage-related protein. (788 aa)
clpBClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (866 aa)
ftsH3FtsH3; Predicted cell division protein FtsH homolog; Belongs to the AAA ATPase family. (588 aa)
livFLivF; Predicted branched-chain amino acid transport ATP-binding protein. (233 aa)
livGLivG; Predicted branched-chain amino acid transport ATP-binding protein. (256 aa)
CKL_2754Conserved hypothetical protein. (860 aa)
potAPredicted ABC transporter, ATPase component; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. (362 aa)
CKL_2797Predicted ABC transporter, ATPase component. (375 aa)
CKL_2808Predicted DNA repair protein; Belongs to the DNA mismatch repair MutS family. (602 aa)
CKL_2816PhoH-related protein. (458 aa)
CKL_2818Predicted ABC transporter, ATPase component. (241 aa)
gmkGmk; Predicted guanylate kinase. (185 aa)
CKL_2905Predicted metal ABC transporter, ATPase component. (217 aa)
CKL_2924Phage-related protein. (472 aa)
CKL_2948Phage-related protein. (768 aa)
CKL_3011Predicted ABC transporter, ATPase component. (243 aa)
CKL_3021Predicted transcriptional regulator. (480 aa)
CKL_3042Predicted ABC transporter, ATPase component. (225 aa)
CKL_3047Predicted transporter. (303 aa)
CKL_3054Predicted transport protein. (107 aa)
CKL_3058Predicted ABC transporter, ATP-binding protein. (257 aa)
nifH4NifH4; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (272 aa)
CKL_3085Predicted transport protein. (356 aa)
ruvBRuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (350 aa)
hflXConserved hypothetical protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. (592 aa)
mutS2MutS-related protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (786 aa)
CKL_3236Phage-related protein. (769 aa)
CKL_3240Type III restriction-modification system, restriction subunit. (986 aa)
CKL_3241Predicted ATP-dependent endonuclease. (539 aa)
CKL_3280Conserved hypothetical protein. (450 aa)
CKL_3324Predicted ABC transporter, ATP-binding protein. (252 aa)
CKL_3331Predicted RNA helicase. (524 aa)
engBEngB; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (197 aa)
lonLon; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (774 aa)
clpXClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (430 aa)
CKL_3392Hypothetical protein. (221 aa)
CKL_3416Hypothetical protein; Belongs to the EutP/PduV family. (156 aa)
CKL_3420Hypothetical protein; Belongs to the EutP/PduV family. (148 aa)
cbiOCbiO; Part of an ABC transporter complex. Responsible for energy coupling to the transport system. (277 aa)
CKL_3438Predicted signal transduction and transcriptional regulator protein. (659 aa)
pcrAPcrA; ATP-dependent DNA helicase. (745 aa)
CKL_3511Predicted ABC transporter, ATPase component. (265 aa)
CKL_3521Predicted ABC transporter, ATPase component. (241 aa)
CKL_3534Predicted ABC transporter, ATPase component. (252 aa)
CKL_3538Conserved hypothetical protein. (60 aa)
CKL_3542Predicted ABC transporter, ATPase component. (270 aa)
CKL_3552Predicted ABC transporter, ATPase component. (227 aa)
CKL_3564Conserved hypothetical protein, predicted to be ATP-binding; Displays ATPase and GTPase activities. (293 aa)
uvrAUvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (940 aa)
uvrBUvrB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA prein [...] (664 aa)
ftsEPredicted ATPase involved in cell division; Part of the ABC transporter FtsEX involved in cellular division. (228 aa)
CKL_3596Conserved hypothetical protein containing an uridine kinase domain. (571 aa)
CKL_3614Predicted ABC transporter, ATPase component. (229 aa)
secASecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (834 aa)
CKL_3648Predicted ATP-binding protein containing a ferredoxin domain. (282 aa)
CKL_3649Predicted ATP-binding protein containing a ferredoxin domain. (276 aa)
CKL_3651Predicted nucleotide-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (278 aa)
recD2Predicted exodeoxyribonuclease; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (750 aa)
atpDAtpD; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (464 aa)
atpAAtpA; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (504 aa)
rhoTranscription termination factor rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (484 aa)
pyrGPyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
CKL_3734Predicted transport protein, ATPase and permease component. (597 aa)
CKL_3735Predicted transport protein, ATPase and permease component. (580 aa)
CKL_3747Hypothetical protein. (1352 aa)
CKL_3793DNA polymerase-related protein. (314 aa)
tmkTmk; Predicted thymidylate kinase. (228 aa)
dnaXDnaX; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (553 aa)
CKL_3835Protease-related protein. (376 aa)
CKL_3847Predicted transporter protein. (227 aa)
CKL_3852Predicted ABC transporter, ATPase component. (311 aa)
CKL_3861TraG-related protein. (600 aa)
CKL_3876Conserved hypothetical protein. (609 aa)
CKL_3888Conserved hypothetical protein. (450 aa)
CKL_3889Conserved hypothetical protein. (271 aa)
CKL_3902Predicted DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (444 aa)
CKL_3903La-related protease. (631 aa)
parAParA; Predicted chromosome partitioning protein. (228 aa)
trmETrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (459 aa)
Your Current Organism:
Clostridium kluyveri
NCBI taxonomy Id: 431943
Other names: C. kluyveri DSM 555, Clostridium kluyveri DSM 555, Clostridium kluyveri str. DSM 555, Clostridium kluyveri strain DSM 555
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