(18 nodes) Class I glutamine amidotransferase-like network (Clostridium kluyveri)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

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Your Input:
	CKL_3799	Conserved hypothetical protein. (304 aa)
	CKL_0373	Predicted amidotransferase. (236 aa)
	guaA	GuaA; Catalyzes the synthesis of GMP from XMP. (510 aa)
	carA1	CarA1; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (349 aa)
	cbiP	CbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (499 aa)
	cbiB	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (440 aa)
	trpG	TrpG; Anthranilate synthase component II. (194 aa)
	purL	PurL; Predicted phosphoribosylformylglycinamidine synthase. (1257 aa)
	hisH	HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa)
	metA1	MetA1; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (309 aa)
	metA2	MetA2; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (304 aa)
	CKL_2142	Conserved hypothetical protein. (186 aa)
	carA2	CarA2; Carbamoyl-phosphate synthase large chain; Belongs to the CarA family. (354 aa)
	pdxT	PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (188 aa)
	CKL_2701	Cobyric acid synthase-related protein. (243 aa)
	CKL_2877	Conserved hypothetical protein. (307 aa)
	pyrG	PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
	cphB	CphB; Cyanophycinase; Belongs to the peptidase S51 family. (262 aa)

Your Current Organism:

Clostridium kluyveri

NCBI taxonomy Id: 431943
Other names: C. kluyveri DSM 555, Clostridium kluyveri DSM 555, Clostridium kluyveri str. DSM 555, Clostridium kluyveri strain DSM 555

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CKL_0373	purL	CKL_0373	CKL_1286	Predicted amidotransferase.	PurL; Predicted phosphoribosylformylglycinamidine synthase.	0.663
CKL_2142	guaA	CKL_2142	CKL_0466	Conserved hypothetical protein.	GuaA; Catalyzes the synthesis of GMP from XMP.	0.407
carA1	carA2	CKL_0649	CKL_2375	CarA1; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.	CarA2; Carbamoyl-phosphate synthase large chain; Belongs to the CarA family.	0.904
carA1	guaA	CKL_0649	CKL_0466	CarA1; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.	GuaA; Catalyzes the synthesis of GMP from XMP.	0.424
carA1	purL	CKL_0649	CKL_1286	CarA1; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.	PurL; Predicted phosphoribosylformylglycinamidine synthase.	0.874
carA2	carA1	CKL_2375	CKL_0649	CarA2; Carbamoyl-phosphate synthase large chain; Belongs to the CarA family.	CarA1; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.	0.904
carA2	guaA	CKL_2375	CKL_0466	CarA2; Carbamoyl-phosphate synthase large chain; Belongs to the CarA family.	GuaA; Catalyzes the synthesis of GMP from XMP.	0.424
carA2	purL	CKL_2375	CKL_1286	CarA2; Carbamoyl-phosphate synthase large chain; Belongs to the CarA family.	PurL; Predicted phosphoribosylformylglycinamidine synthase.	0.858
cbiB	cbiP	CKL_0722	CKL_0721	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	CbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	0.996
cbiP	cbiB	CKL_0721	CKL_0722	CbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.	CbiB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	0.996
guaA	CKL_2142	CKL_0466	CKL_2142	GuaA; Catalyzes the synthesis of GMP from XMP.	Conserved hypothetical protein.	0.407
guaA	carA1	CKL_0466	CKL_0649	GuaA; Catalyzes the synthesis of GMP from XMP.	CarA1; Carbamoyl-phosphate synthase small chain; Belongs to the CarA family.	0.424
guaA	carA2	CKL_0466	CKL_2375	GuaA; Catalyzes the synthesis of GMP from XMP.	CarA2; Carbamoyl-phosphate synthase large chain; Belongs to the CarA family.	0.424
guaA	hisH	CKL_0466	CKL_1298	GuaA; Catalyzes the synthesis of GMP from XMP.	HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	0.476
guaA	purL	CKL_0466	CKL_1286	GuaA; Catalyzes the synthesis of GMP from XMP.	PurL; Predicted phosphoribosylformylglycinamidine synthase.	0.988
guaA	pyrG	CKL_0466	CKL_3715	GuaA; Catalyzes the synthesis of GMP from XMP.	PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.943
hisH	guaA	CKL_1298	CKL_0466	HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	GuaA; Catalyzes the synthesis of GMP from XMP.	0.476
hisH	purL	CKL_1298	CKL_1286	HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.	PurL; Predicted phosphoribosylformylglycinamidine synthase.	0.430
metA1	metA2	CKL_1609	CKL_1631	MetA1; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	MetA2; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	0.902
metA2	metA1	CKL_1631	CKL_1609	MetA2; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	MetA1; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.	0.902