STRINGSTRING
gyrB1 gyrB1 vanS vanS CKL_0038 CKL_0038 CKL_0149 CKL_0149 CKL_0361 CKL_0361 CKL_0389 CKL_0389 CKL_0561 CKL_0561 CKL_0585 CKL_0585 CKL_0652 CKL_0652 CKL_0686 CKL_0686 CKL_0687 CKL_0687 CKL_0965 CKL_0965 CKL_1056 CKL_1056 CKL_1071 CKL_1071 CKL_1108 CKL_1108 cheA1 cheA1 CKL_1290 CKL_1290 phoR phoR CKL_1360 CKL_1360 CKL_1466 CKL_1466 kdpD kdpD CKL_1494 CKL_1494 mutL mutL CKL_1642 CKL_1642 CKL_1681 CKL_1681 cheA2 cheA2 gyrB2 gyrB2 CKL_2145 CKL_2145 htpG htpG CKL_2263 CKL_2263 CKL_2319 CKL_2319 CKL_2349 CKL_2349 CKL_2384 CKL_2384 CKL_2438 CKL_2438 CKL_2547 CKL_2547 CKL_2612 CKL_2612 CKL_2806 CKL_2806 CKL_3004 CKL_3004 CKL_3043 CKL_3043 CKL_3045 CKL_3045 CKL_3112 CKL_3112 CKL_3117 CKL_3117 spoIIAB spoIIAB CKL_3203 CKL_3203 CKL_3318 CKL_3318 CKL_3368 CKL_3368 CKL_3393 CKL_3393 CKL_3543 CKL_3543 CKL_3553 CKL_3553 CKL_3639 CKL_3639 CKL_3853 CKL_3853
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gyrB1GyrB1; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (637 aa)
vanSVanS; Sensor protein VanS. (384 aa)
CKL_0038Predicted sensory transduction histidine kinase. (478 aa)
CKL_0149Predicted sensory transduction histidine kinase. (471 aa)
CKL_0361Two component sensor kinase. (340 aa)
CKL_0389Two-component sensor kinase. (422 aa)
CKL_0561Two component sensor kinase. (353 aa)
CKL_0585Conserved hypothetical protein. (112 aa)
CKL_0652Two component sensor kinase. (405 aa)
CKL_0686Two component sensor kinase. (451 aa)
CKL_0687Two component sensor kinase. (318 aa)
CKL_0965Two component sensor kinase. (309 aa)
CKL_1056Two component sensor kinase. (326 aa)
CKL_1071Predicted two-component sensor histidine kinase. (404 aa)
CKL_1108Predicted sensor protein. (652 aa)
cheA1CheA1; Chemotaxis protein CheA. (674 aa)
CKL_1290Predicted sensor kinase. (425 aa)
phoRPhoR; Predicted phosphate regulon sensor protein. (575 aa)
CKL_1360Two component sensor kinase. (453 aa)
CKL_1466Predicted sensor kinase. (437 aa)
kdpDKdpD; Sensor kinase. (898 aa)
CKL_1494Predicted sensory transduction histidine kinase. (461 aa)
mutLMutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (609 aa)
CKL_1642Predicted two component sensor kinase. (416 aa)
CKL_1681Predicted two component sensor kinase. (455 aa)
cheA2CheA2; Chemotaxis histidine kinase. (692 aa)
gyrB2GyrB2; DNA gyrase subunit B. (649 aa)
CKL_2145Two component sensor kinase. (413 aa)
htpGHtpG; Molecular chaperone. Has ATPase activity. (624 aa)
CKL_2263Predicted sensory transduction histidine kinase. (663 aa)
CKL_2319Predicted sensor kinase. (300 aa)
CKL_2349Predicted sensory transduction histidine kinase. (509 aa)
CKL_2384Chaperone-related protein. (1013 aa)
CKL_2438Predicted sensory transduction histidine kinase. (219 aa)
CKL_2547Two component sensor kinase. (351 aa)
CKL_2612Predicted sensory transduction histidine kinase. (329 aa)
CKL_2806Predicted sensor protein. (621 aa)
CKL_3004Predicted sensory transduction histidine kinase. (437 aa)
CKL_3043Predicted sensory transduction histidine kinase. (342 aa)
CKL_3045Predicted sensory transduction histidine kinase. (470 aa)
CKL_3112Predicted sensor kinase. (321 aa)
CKL_3117Predicted sensor kinase. (617 aa)
spoIIABSpoIIAB; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (142 aa)
CKL_3203Histidine kinase-related protein. (745 aa)
CKL_3318Predicted two-component sensor histidine kinase. (419 aa)
CKL_3368Predicted two-component sensor histidine kinase. (438 aa)
CKL_3393Hypothetical protein. (346 aa)
CKL_3543Predicted sensory transduction histidine kinase. (336 aa)
CKL_3553Predicted sensory transduction histidine kinase. (345 aa)
CKL_3639Predicted signal transduction histidine kinase component. (290 aa)
CKL_3853Predicted sensory transduction kinase. (307 aa)
Your Current Organism:
Clostridium kluyveri
NCBI taxonomy Id: 431943
Other names: C. kluyveri DSM 555, Clostridium kluyveri DSM 555, Clostridium kluyveri str. DSM 555, Clostridium kluyveri strain DSM 555
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.