STRINGSTRING
leuA1 leuA1 accB accB accC accC accD accD accA accA fumA fumA fumB fumB pyc pyc CKL_0846 CKL_0846 ppdK ppdK CKL_1074 CKL_1074 CKL_1077 CKL_1077 pfl pfl gloA gloA ldh ldh pta pta ackA ackA aad aad CKL_1654 CKL_1654 CKL_1730 CKL_1730 nifV1 nifV1 nifV2 nifV2 bfmBC bfmBC CKL_2138 CKL_2138 leuA2 leuA2 CKL_2209 CKL_2209 lpdA lpdA pdhC pdhC maeB maeB CKL_2552 CKL_2552 pck pck porB porB porA porA porD porD porC porC cat1 cat1 CKL_3129 CKL_3129 CKL_3322 CKL_3322 CKL_3337 CKL_3337 pyk pyk thlA1 thlA1 thlA2 thlA2 thlA3 thlA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
leuA1LeuA1; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (553 aa)
accBAccB; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (170 aa)
accCAccC; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
accDAccD; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa)
accAAccA; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (281 aa)
fumAFumarate hydratase, alpha subunit. (280 aa)
fumBFumB; Fumarate hydratase, beta subunit. (188 aa)
pycPyc; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1146 aa)
CKL_0846Predicted microcompartment protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (220 aa)
ppdKPpdK; Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (880 aa)
CKL_1074Acetaldehyde dehydrogenase. (491 aa)
CKL_1077Predicted alcohol dehydrogenase. (435 aa)
pflPfl; Pyruvate formate-lyase. (744 aa)
gloAGloA; Predicted lactoylglutathione lyase. (121 aa)
ldhHypothetical protein; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (315 aa)
ptaPta; Phosphotransacetylase. (333 aa)
ackAAckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (405 aa)
aadAad; Bicunctional aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (876 aa)
CKL_1654Phosphoenolpyruvate synthase-related protein. (772 aa)
CKL_1730Polyketide synthase-related protein. (720 aa)
nifV1NifV1; Homocitrate synthase, alpha subunit; Belongs to the alpha-IPM synthase/homocitrate synthase family. (269 aa)
nifV2NifV2; Homocitrate synthase, omega subunit. (353 aa)
bfmBCBfmBC; Dihydrolipoyl dehydrogenase. (455 aa)
CKL_2138Pyruvate-flavodoxin oxidoreductase. (1169 aa)
leuA2LeuA2; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa)
CKL_2209Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (474 aa)
lpdALpdA; Dihydrolipoyl dehydrogenase (E3 component of pyruvatedehydrogenase complex). (576 aa)
pdhCPdhC; Dihydrolipoyllysine-residue acetyltransferase (E2 component of pyruvatedehydrogenase complex). (444 aa)
maeBMaeB; NADP-dependent malic enzyme. (410 aa)
CKL_2552Conserved hypothetical protein. (280 aa)
pckPck; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (528 aa)
porBPorB; Pyruvate:ferredoxin oxidoreductase. (310 aa)
porAPorA; Pyruvate:ferredoxin oxidoreductase. (393 aa)
porDPorD; Pyruvate:ferredoxin oxidoreductase. (99 aa)
porCPorC; Pyruvate:ferredoxin oxidoreductase. (191 aa)
cat1Cat1; Forms succinyl-CoA from succinate and acetyl-CoA; Belongs to the acetyl-CoA hydrolase/transferase family. (538 aa)
CKL_3129Conserved hypothetical protein. (199 aa)
CKL_3322Predicted hydrolase. (302 aa)
CKL_3337Automatic annotation. (1172 aa)
pykPyk; Pyruvate kinase; Belongs to the pyruvate kinase family. (585 aa)
thlA1ThlA1; acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
thlA2ThlA2; acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
thlA3ThlA3; acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
Your Current Organism:
Clostridium kluyveri
NCBI taxonomy Id: 431943
Other names: C. kluyveri DSM 555, Clostridium kluyveri DSM 555, Clostridium kluyveri str. DSM 555, Clostridium kluyveri strain DSM 555
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.