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| | CKL_0030 | Predicted hydrolase. (287 aa) |
| | CKL_0044 | Predicted citrate synthase; Belongs to the citrate synthase family. (449 aa) |
| | leuA1 | LeuA1; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (553 aa) |
| | psd | Psd; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (296 aa) |
| | acp1 | Acp1; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (75 aa) |
| | fabD | FabD; malonyl-CoA-acyl carrier protein transacylase. (312 aa) |
| | fabG1 | FabG1; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | accB | AccB; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (170 aa) |
| | accC | AccC; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | accD | AccD; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa) |
| | accA | AccA; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (281 aa) |
| | prs | Prs; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | hpt | Hpt; Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa) |
| | ispD | IspD; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (231 aa) |
| | adk | Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | CKL_0268 | Histidinol-phosphatase-related protein; Belongs to the PHP hydrolase family. HisK subfamily. (277 aa) |
| | fumA | Fumarate hydratase, alpha subunit. (280 aa) |
| | fumB | FumB; Fumarate hydratase, beta subunit. (188 aa) |
| | proC1 | ProC1; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa) |
| | CKL_0327 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (93 aa) |
| | CKL_0375 | Predicted Fe-S oxidoreductase. (392 aa) |
| | CKL_0376 | Predicted Fe-S oxidoreductase. (330 aa) |
| | CKL_0377 | Transcriptional regulator. (144 aa) |
| | ilvE1 | IlvE1; Predicted threonine dehydratase. (412 aa) |
| | serA | SerA; Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa) |
| | CKL_0439 | Predicted aminotransferase. (396 aa) |
| | bcd | Bcd; butyryl-CoA dehydrogenase. (379 aa) |
| | CKL_0460 | Glutamate synthase-related protein. (463 aa) |
| | guaB | GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | idh | Idh; Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (401 aa) |
| | lysC1 | LysC1; Aspartokinase; Belongs to the aspartokinase family. (399 aa) |
| | lysA | LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (431 aa) |
| | panB | PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (280 aa) |
| | panC | PanC; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (292 aa) |
| | hemA | HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (415 aa) |
| | hemL | HemL; Glutamate-1-semialdehyde 2,1-aminomutase. (422 aa) |
| | sdhB | SdhB; L-serine dehydratase, beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (227 aa) |
| | sdhA | SdhA; L-serine dehydratase, alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (292 aa) |
| | thrC | ThrC; Threonine synthase. (496 aa) |
| | hemB | HemB; Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (322 aa) |
| | hemC | HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (305 aa) |
| | hemD | HemD; Porphyrin biosynthesis protein HemD. (490 aa) |
| | CKL_0774 | Predicted succinate dehydrogenase iron-sulfur protein. (233 aa) |
| | CKL_0780 | Predicted short-chain dehydrogenase. (247 aa) |
| | aroF | AroF; Phospho-2-dehydro-3-deoxyheptonate aldolase. (344 aa) |
| | tyrA | TyrA; Prephenate dehydrogenase. (290 aa) |
| | aroB | AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa) |
| | aroA | AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa) |
| | aroC | AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (360 aa) |
| | pheA | PheA; Predicted bifunctional chorismate mutase/ prephenate dehydratase. (379 aa) |
| | aroE1 | AroE1; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa) |
| | aroK | AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (169 aa) |
| | fbp | Fbp; Fructose-1,6-bisphosphatase. (666 aa) |
| | pheB | PheB; Predicted phenylalanine biosynthesis protein; Belongs to the UPF0735 family. (145 aa) |
| | hom1 | Hom1; Homoserine dehydrogenase. (413 aa) |
| | thrB | ThrB; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (300 aa) |
| | aspC1 | AspC1; Predicted aspartate aminotransferase. (396 aa) |
| | CKL_0899 | Oxygen independent coproporphyrinogen III oxidase-related protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (383 aa) |
| | CKL_0914 | Predicted diacylglycerol kinase. (232 aa) |
| | ppdK | PpdK; Pyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (880 aa) |
| | gyaR | GyaR; Predicted glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | proB2 | ProB2; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (268 aa) |
| | CKL_0972 | Predicted acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (241 aa) |
| | CKL_0973 | 2-isopropylmalate synthase-related protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with oxaloacetate to form citrate. This enzyme is highly Re-face stereospecific with respect to the C-2 of oxaloacetate. (453 aa) |
| | CKL_0974 | Aconitase-related protein. (641 aa) |
| | metH1 | MetH1; Predicted methionine synthase. (801 aa) |
| | argG | ArgG; Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa) |
| | argH | ArgH; Argininosuccinate lyase. (438 aa) |
| | CKL_0995 | Predicted glucose-1-phosphate nucleotidyltransferase containing an additional conserved domain. (814 aa) |
| | surE | SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (245 aa) |
| | tal | Tal; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | metB1 | MetB1; Cystathione gamma-synthase. (382 aa) |
| | cysK | CysK; Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | aroD | AroD; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (255 aa) |
| | aroE2 | AroE2; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa) |
| | aroE3 | AroE3; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (289 aa) |
| | asnB | AsnB; Predicted asparagine synthetase. (613 aa) |
| | CKL_1030 | Predicted aminotransferase. (391 aa) |
| | CKL_1067 | Predicted iron containing alcohol dehydrogenase. (390 aa) |
| | CKL_1077 | Predicted alcohol dehydrogenase. (435 aa) |
| | ilvC1 | IlvC1; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | ilvB1 | IlvB1; Predicted acetolactate synthase, large subunit. (553 aa) |
| | ilvC2 | IlvC2; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | hom2 | Hom2; Homoserine dehydrogenase. (433 aa) |
| | dapF | DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | fps | Fps; Predicted geranyltranstransferase; Belongs to the FPP/GGPP synthase family. (293 aa) |
| | dxs | Dxs; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (624 aa) |
| | CKL_1270 | Heptaprenyl diphosphate synthase-related protein. (172 aa) |
| | trpE | TrpE; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (476 aa) |
| | trpG | TrpG; Anthranilate synthase component II. (194 aa) |
| | trpD | TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (335 aa) |
| | trpC | TrpC; Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | trpF | TrpF; N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (199 aa) |
| | trpB1 | TrpB1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | glyA | GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa) |
| | purL | PurL; Predicted phosphoribosylformylglycinamidine synthase. (1257 aa) |
| | hisZ | HisZ; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (391 aa) |
| | hisG | HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (219 aa) |
| | hisD | HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | hisC | HisC; Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa) |
| | hisB | HisB; Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisH | HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (202 aa) |
| | hisA | HisA; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase. (238 aa) |
| | hisF | HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) |
| | hisI | HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (106 aa) |
| | hisE | HisE; phosphoribosyl-ATP pyrophosphatase. (105 aa) |
| | hisK | HisK; Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (257 aa) |
| | gpsA | GpsA; Predicted glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa) |
| | CKL_1377 | Pentose phosphate epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa) |
| | ldh | Hypothetical protein; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (315 aa) |
| | plsX | Hypothetical protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (334 aa) |
| | acpP | Hypothetical protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa) |
| | uppS1 | UppS1; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (254 aa) |
| | CKL_1422 | Predicted phosphatidate cytidylyltransferase; Belongs to the CDS family. (268 aa) |
| | dxr | Dxr; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (385 aa) |
| | ispG | IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (349 aa) |
| | ribF | RibF; Predicted riboflavin biosynthesis protein; Belongs to the ribF family. (312 aa) |
| | lysC2 | LysC2; Aspartokinase; Belongs to the aspartokinase family. (399 aa) |
| | aspC2 | AspC2; Aspartate aminotransferase. (397 aa) |
| | purB | PurB; Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa) |
| | gluS | GluS; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (487 aa) |
| | gap | Gap; Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (351 aa) |
| | CKL_1485 | Conserved hypothetical protein. (238 aa) |
| | menG | Predicted methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (235 aa) |
| | CKL_1497 | Predicted transferase. (215 aa) |
| | argC | ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | argJ | ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa) |
| | argB | ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (283 aa) |
| | argD | ArgD; Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase-related protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (637 aa) |
| | aspC3 | AspC3; Aspartate aminotransferase. (398 aa) |
| | CKL_1572 | Predicted methyltransferase. (220 aa) |
| | miaA | MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (309 aa) |
| | CKL_1597 | Transcriptional regulator. (317 aa) |
| | malL | MalL; Predicted oligo-1,6-glucosidase. (565 aa) |
| | punA | PunA; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (272 aa) |
| | metA1 | MetA1; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (309 aa) |
| | aad | Aad; Bicunctional aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (876 aa) |
| | ilvH | IlvH; Acetolactate synthase, small subunit. (165 aa) |
| | ilvI | IlvI; Acetolactate synthase, large subunit. (536 aa) |
| | gltD | GltD; Glutamate synthase, small subunit. (477 aa) |
| | gltB | GltB; Glutamate synthase, large subunit. (1509 aa) |
| | panD | PanD; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa) |
| | ndk | Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (135 aa) |
| | metA2 | MetA2; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (304 aa) |
| | metK1 | MetK1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (403 aa) |
| | CKL_1654 | Phosphoenolpyruvate synthase-related protein. (772 aa) |
| | ilvD | IlvD; Predicted dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (556 aa) |
| | CKL_1710 | Conserved hypothetical protein. (85 aa) |
| | CKL_1732 | Predicted PKS acyltransferase domain. (424 aa) |
| | metH2 | MetH2; Predicted methionine synthase. (590 aa) |
| | metE | MetE; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (762 aa) |
| | bfmBC | BfmBC; Dihydrolipoyl dehydrogenase. (455 aa) |
| | gcvPB | GcvPB; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (487 aa) |
| | gcvPA | GcvPA; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (439 aa) |
| | gcvH | GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | gcvT | GcvT; The glycine cleavage system catalyzes the degradation of glycine. (362 aa) |
| | CKL_1778 | Predicted glucose-1-phosphate nucleotidyltransferase containing an additional conserved domain. (814 aa) |
| | CKL_1780 | Glycogen phosphorylase-related protein. (535 aa) |
| | CKL_1782 | Predicted FAD/FMN-containing dehydrogenase. (460 aa) |
| | CKL_1790 | Predicted phosphatase. (216 aa) |
| | cysN | CysN; Sulfate adenylyltransferase. (610 aa) |
| | cysD | CysD; Sulfate adenylyltransferase. (266 aa) |
| | CKL_2063 | Hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | fabG2 | FabG2; 3-oxoacyl-[acyl-carrier-protein] reductase. (250 aa) |
| | ilvB2 | IlvB2; Acetolactate synthase, large subunit. (569 aa) |
| | ilvE2 | IlvE2; Predicted branched-chain-amino-acid aminotransferase. (277 aa) |
| | CKL_2138 | Pyruvate-flavodoxin oxidoreductase. (1169 aa) |
| | leuB | LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (354 aa) |
| | leuD | LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa) |
| | leuC | LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa) |
| | leuA2 | LeuA2; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa) |
| | ribH | RibH; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (154 aa) |
| | ribAB | RibAB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (400 aa) |
| | ribE | RibE; Riboflavin synthase alpha chain. (217 aa) |
| | ribD | RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (369 aa) |
| | CKL_2184 | Methionine synthase-related protein. (378 aa) |
| | CKL_2185 | Methionine synthase-related protein. (372 aa) |
| | CKL_2208 | Predicted 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa) |
| | CKL_2209 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (474 aa) |
| | CKL_2259 | Predicted homocysteine S-methyltransferase. (313 aa) |
| | lpdA | LpdA; Dihydrolipoyl dehydrogenase (E3 component of pyruvatedehydrogenase complex). (576 aa) |
| | pdhC | PdhC; Dihydrolipoyllysine-residue acetyltransferase (E2 component of pyruvatedehydrogenase complex). (444 aa) |
| | asn | Asn; Predicted asparagine synthetase. (529 aa) |
| | CKL_2356 | Predicted PKS acyl carrier. (421 aa) |
| | argF | ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (336 aa) |
| | metK2 | MetK2; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (397 aa) |
| | purD | PurD; Predicted phosphoribosylamine--glycine ligase; Belongs to the GARS family. (413 aa) |
| | purH | PurH; Predicted bifunctional purine biosynthesis protein purH. (499 aa) |
| | purN | PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa) |
| | purM | PurM; Phosphoribosylformylglycinamidine cyclo-ligase. (331 aa) |
| | purF | PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (483 aa) |
| | purC | PurC; Predicted phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (235 aa) |
| | purE | PurE; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa) |
| | pck | Pck; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (528 aa) |
| | ltaA | LtaA; L-allo-threonine aldolase. (342 aa) |
| | proA | ProA; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | proB1 | ProB1; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (272 aa) |
| | proC2 | ProC2; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (283 aa) |
| | dapB1 | DapB1; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (271 aa) |
| | sirC | SirC; Predicted precorrin-2 dehydrogenase. (208 aa) |
| | aroH | AroH; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (342 aa) |
| | CKL_2967 | Predicted iron containing alcohol dehydrogenase. (390 aa) |
| | CKL_2978 | Predicted iron containing alcohol dehydrogenase. (390 aa) |
| | porB | PorB; Pyruvate:ferredoxin oxidoreductase. (310 aa) |
| | porA | PorA; Pyruvate:ferredoxin oxidoreductase. (393 aa) |
| | porD | PorD; Pyruvate:ferredoxin oxidoreductase. (99 aa) |
| | porC | PorC; Pyruvate:ferredoxin oxidoreductase. (191 aa) |
| | CKL_3000 | Predicted iron containing alcohol dehydrogenase. (390 aa) |
| | cat1 | Cat1; Forms succinyl-CoA from succinate and acetyl-CoA; Belongs to the acetyl-CoA hydrolase/transferase family. (538 aa) |
| | acp2 | Acp2; Acyl carrier protein. (80 aa) |
| | trpB2 | TrpB2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (460 aa) |
| | galU | GalU; UTP--glucose-1-phosphate uridylyltransferase. (308 aa) |
| | pgm2 | Pgm2; Predicted phosphoglucomutase. (575 aa) |
| | dapB2 | DapB2; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) |
| | dapA4 | DapA4; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | asd | Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (328 aa) |
| | CKL_3332 | Conserved hypothetical protein; Belongs to the glycosyl hydrolase 57 family. (528 aa) |
| | uppS2 | UppS2; Predicted undecaprenyl pyrophosphate synthase. (214 aa) |
| | CKL_3337 | Automatic annotation. (1172 aa) |
| | CKL_3363 | Hypothetical protein. (293 aa) |
| | eno | Hypothetical protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | gpmI | Hypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa) |
| | tpiA | Hypothetical protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | pgk | Hypothetical protein; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | CKL_3382 | Hypothetical protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | CKL_3411 | Hypothetical protein. (239 aa) |
| | CKL_3412 | Hypothetical protein. (218 aa) |
| | CKL_3413 | Hypothetical protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | CKL_3419 | Hypothetical protein. (328 aa) |
| | CKL_3425 | Predicted iron containing alcohol dehydrogenase. (390 aa) |
| | CKL_3489 | Pullulanase-related protein; Belongs to the glycosyl hydrolase 13 family. (704 aa) |
| | pgi | Pgi; Glucose-6-phosphate isomerase; Belongs to the GPI family. (449 aa) |
| | glgD | GlgD; Glycogen biosynthesis protein. (370 aa) |
| | glgC | GlgC; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (383 aa) |
| | apu | Apu; Amylopullulanase precursor. (596 aa) |
| | glgP | GlgP; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (812 aa) |
| | glgA | GlgA; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (475 aa) |
| | glgB | GlgB; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (655 aa) |
| | CKL_3515 | Predicted FAD/FMN-containing dehydrogenase. (468 aa) |
| | pyk | Pyk; Pyruvate kinase; Belongs to the pyruvate kinase family. (585 aa) |
| | pfk1 | Pfk1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (318 aa) |
| | tktB | TktB; Predicted transketolase, subunit B. (313 aa) |
| | tktA | TktA; Predicted transketolase, subunit A. (274 aa) |
| | pssA | PssA; Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (173 aa) |
| | fba | Fba; Fructose-bisphosphate aldolase. (313 aa) |
| | ilvE3 | IlvE3; Branched-chain amino acid aminotransferase. (344 aa) |
| | metK3 | MetK3; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (391 aa) |
| | thlA1 | ThlA1; acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | thlA2 | ThlA2; acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | thlA3 | ThlA3; acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | CKL_3703 | Predicted sugar isomerase of the lacAB/rpiB family. (149 aa) |
| | ispE | IspE; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (280 aa) |
| | manC | ManC; Predicted mannose-1-phosphate guanylyltransferase. (355 aa) |
| | CKL_3771 | Predicted hydrolase. (497 aa) |
| | ispF | IspF; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (164 aa) |
| | CKL_3816 | Predicted phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (310 aa) |
