STRINGSTRING
CKL_0044 CKL_0044 leuA1 leuA1 CKL_0439 CKL_0439 idh idh lysC1 lysC1 aspC1 aspC1 CKL_0973 CKL_0973 CKL_0974 CKL_0974 ilvC1 ilvC1 ilvB1 ilvB1 ilvC2 ilvC2 lysC2 lysC2 aspC2 aspC2 argC argC argJ argJ argB argB argD argD aspC3 aspC3 ilvH ilvH ilvI ilvI ilvD ilvD ilvB2 ilvB2 ilvE2 ilvE2 leuB leuB leuD leuD leuC leuC leuA2 leuA2 asd asd ilvE3 ilvE3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CKL_0044Predicted citrate synthase; Belongs to the citrate synthase family. (449 aa)
leuA1LeuA1; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (553 aa)
CKL_0439Predicted aminotransferase. (396 aa)
idhIdh; Isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (401 aa)
lysC1LysC1; Aspartokinase; Belongs to the aspartokinase family. (399 aa)
aspC1AspC1; Predicted aspartate aminotransferase. (396 aa)
CKL_09732-isopropylmalate synthase-related protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with oxaloacetate to form citrate. This enzyme is highly Re-face stereospecific with respect to the C-2 of oxaloacetate. (453 aa)
CKL_0974Aconitase-related protein. (641 aa)
ilvC1IlvC1; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
ilvB1IlvB1; Predicted acetolactate synthase, large subunit. (553 aa)
ilvC2IlvC2; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
lysC2LysC2; Aspartokinase; Belongs to the aspartokinase family. (399 aa)
aspC2AspC2; Aspartate aminotransferase. (397 aa)
argCArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa)
argJArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa)
argBArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (283 aa)
argDArgD; Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa)
aspC3AspC3; Aspartate aminotransferase. (398 aa)
ilvHIlvH; Acetolactate synthase, small subunit. (165 aa)
ilvIIlvI; Acetolactate synthase, large subunit. (536 aa)
ilvDIlvD; Predicted dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (556 aa)
ilvB2IlvB2; Acetolactate synthase, large subunit. (569 aa)
ilvE2IlvE2; Predicted branched-chain-amino-acid aminotransferase. (277 aa)
leuBLeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (354 aa)
leuDLeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
leuCLeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (420 aa)
leuA2LeuA2; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa)
asdAsd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (328 aa)
ilvE3IlvE3; Branched-chain amino acid aminotransferase. (344 aa)
Your Current Organism:
Clostridium kluyveri
NCBI taxonomy Id: 431943
Other names: C. kluyveri DSM 555, Clostridium kluyveri DSM 555, Clostridium kluyveri str. DSM 555, Clostridium kluyveri strain DSM 555
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.