STRINGSTRING
AQS83434.1 AQS83434.1 prs prs purF purF adk adk gmk gmk AQS83609.1 AQS83609.1 AQS83619.1 AQS83619.1 AQS86189.1 AQS86189.1 apt apt AQS83790.1 AQS83790.1 AQS84079.1 AQS84079.1 purC purC purS purS purQ purQ purL purL purH purH ndk ndk ureC ureC ureB ureB ureA ureA guaB guaB purN purN purM purM AQS86330.1 AQS86330.1 cysC cysC AQS84703.1 AQS84703.1 AQS84726.1 AQS84726.1 purE purE purK purK gpt gpt AQS85067.1 AQS85067.1 AQS85189.1 AQS85189.1 AQS85190.1 AQS85190.1 AQS85191.1 AQS85191.1 AQS85192.1 AQS85192.1 AQS85194.1 AQS85194.1 AQS85195.1 AQS85195.1 AQS85200.1 AQS85200.1 AQS85201.1 AQS85201.1 AQS85213.1 AQS85213.1 AQS85230.1 AQS85230.1 purD purD AQS85424.1 AQS85424.1 AQS85556.1 AQS85556.1 AQS85574.1 AQS85574.1 AQS85616.1 AQS85616.1 purA purA AQS86049.1 AQS86049.1 guaA guaA AQS86122.1 AQS86122.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AQS83434.1Nucleoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
prsPhosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (488 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (222 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (216 aa)
AQS83609.1Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
AQS83619.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (477 aa)
AQS86189.1Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa)
AQS83790.1Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
AQS84079.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (449 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (254 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (80 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (233 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (736 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
ureCUrease subunit alpha; Ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; Derived by automated computational analysis using gene prediction method: Protein Homology. (568 aa)
ureBUrease subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease beta subunit family. (113 aa)
ureAUrease subunit gamma; UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the urease gamma subunit family. (100 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (492 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (208 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
AQS86330.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (625 aa)
AQS84703.1Sulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
AQS84726.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (772 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (152 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (358 aa)
gptXanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (161 aa)
AQS85067.1Exopolyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (496 aa)
AQS85189.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
AQS85190.1Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
AQS85191.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
AQS85192.1Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
AQS85194.1OHCU decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
AQS85195.15-hydroxyisourate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (117 aa)
AQS85200.1Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (333 aa)
AQS85201.1Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (632 aa)
AQS85213.1Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
AQS85230.1Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (426 aa)
AQS85424.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (751 aa)
AQS85556.1Vitamin B12-dependent ribonucleotide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (550 aa)
AQS85574.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 5'-nucleotidase family. (661 aa)
AQS85616.1ADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
AQS86049.1Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
guaAGMP synthetase; Catalyzes the synthesis of GMP from XMP. (533 aa)
AQS86122.1Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (445 aa)
Your Current Organism:
Acetobacter aceti
NCBI taxonomy Id: 435
Other names: A. aceti, ATCC 15973, Acetimonas aceti, Acetobacter (subgen. Acetobacter) aceti, Acetobacter aceti aceti, Acetobacter aceti orleanensis, Acetobacter aceti subsp. aceti, Acetobacter aceti var. muciparum, Acetobacter ketogenum, Acetobacter lafarianum, Bacillus aceticus, Bacteriopsis aceti, Bacterium aceti, Bacterium acetigenoidum, Bacterium hansenianum, CCUG 18122, CIP 103111, DSM 3508, ICMP 8807, IFO 14818, JCM 7641, Micrococcus aceti, Mycoderma aceti souches non visqueuses (membraneuses), NBRC 14818, NCCB 23001, NCIB 8621, NCIB:8621, NCIMB 8621
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