Your Input: | |
| | fmt | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (324 aa) |
| | purL | Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1234 aa) |
| | BVU_0092 | Putative phosphoribosylformylglycinamidine cyclo-ligase. (389 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (272 aa) |
| | BVU_0146 | 5'-nucleotidase precursor. (280 aa) |
| | BVU_0147 | Putative 5'-nucleotidase/2',3'-cyclic phosphodiesterase. (259 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa) |
| | BVU_0246 | NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa) |
| | BVU_0251 | NAD-specific glutamate dehydrogenase 1; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa) |
| | BVU_0334 | Formiminotransferase-cyclodeaminase. (300 aa) |
| | BVU_0337 | Putative methenyltetrahydrofolate cyclohydrolase. (207 aa) |
| | BVU_0410 | Glutamine-dependent carbamyl phosphate synthetase. (1073 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (482 aa) |
| | BVU_0551 | Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (321 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (360 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (257 aa) |
| | BVU_0590 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (374 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (322 aa) |
| | BVU_0592 | Argininosuccinate synthase. (402 aa) |
| | BVU_0593 | Conserved hypothetical protein. (185 aa) |
| | argR | Transcriptional regulator; Regulates arginine biosynthesis genes. (158 aa) |
| | argH | Argininosuccinate lyase. (446 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (212 aa) |
| | aroQ | Putative type II 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (140 aa) |
| | BVU_0977 | Uracil phosphoribosyltransferase. (219 aa) |
| | BVU_0983 | Phosphoenolpyruvate carboxykinase. (535 aa) |
| | BVU_0984 | Uracil phosphoribosyltransferase. (219 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (192 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (422 aa) |
| | BVU_1109 | Dihydrolipoamide dehydrogenase. (446 aa) |
| | BVU_1146 | Putative xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (193 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa) |
| | BVU_1257 | Dihydrodipicolinate reductase; Belongs to the DapB family. (251 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (175 aa) |
| | argB | Putative acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (257 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa) |
| | glsA | Glutaminase; Belongs to the glutaminase family. (304 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (169 aa) |
| | gcvH | Putative glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | BVU_1422 | Uridine kinase. (554 aa) |
| | BVU_1483 | Putative peptidase/deacetylase. (354 aa) |
| | BVU_1602 | Purine nucleoside phosphorylase I; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (269 aa) |
| | BVU_1626 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (448 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (189 aa) |
| | BVU_1681 | Putative hypoxanthine guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (189 aa) |
| | BVU_1693 | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. (391 aa) |
| | purH | Phosphoribosylaminoimidazole carboxy formyl formyltransferase. (507 aa) |
| | tdk | Thymidine kinase. (199 aa) |
| | BVU_1839 | Haloacid dehalogenase-like hydrolase. (229 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (409 aa) |
| | BVU_1900 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (353 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa) |
| | BVU_1949 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (164 aa) |
| | thyA | Putative thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | BVU_1951 | Conserved hypothetical protein. (108 aa) |
| | BVU_1952 | RNA polymerase ECF-type sigma factor; Belongs to the sigma-70 factor family. ECF subfamily. (182 aa) |
| | BVU_1953 | Conserved hypothetical protein. (235 aa) |
| | BVU_1954 | tRNA and rRNA cytosine-C5-methylase. (475 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa) |
| | BVU_2050 | Putative aspartokinase I-homoserine dehydrogenase. (810 aa) |
| | BVU_2060 | Chorismate mutase/prephenate dehydratase. (257 aa) |
| | BVU_2061 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase. (355 aa) |
| | BVU_2062 | Putative aminotransferase. (394 aa) |
| | BVU_2063 | Prephenate dehydratase. (280 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa) |
| | BVU_2233 | Putative para-aminobenzoate synthase component I. (327 aa) |
| | BVU_2258 | Dihydroorotase. (446 aa) |
| | BVU_2328 | Putative folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (428 aa) |
| | BVU_2334 | Cytidine deaminase. (159 aa) |
| | BVU_2358 | Uridine kinase. (203 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa) |
| | hisD | Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (346 aa) |
| | hisB | Histidine biosynthesis bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (372 aa) |
| | BVU_2379 | Conserved hypothetical protein. (397 aa) |
| | BVU_2383 | Conserved hypothetical protein. (368 aa) |
| | BVU_2531 | Putative purine permease. (443 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (188 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (358 aa) |
| | BVU_2541 | Shikimate 5-dehydrogenase. (246 aa) |
| | purC | Phosphoribosylamidoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (314 aa) |
| | BVU_2575 | Conserved hypothetical protein. (261 aa) |
| | BVU_2625 | Deoxycytidylate deaminase. (144 aa) |
| | BVU_2726 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor; Belongs to the 5'-nucleotidase family. (580 aa) |
| | BVU_2729 | Conserved hypothetical protein. (703 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (389 aa) |
| | fhs | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (555 aa) |
| | BVU_3019 | Glycine dehydrogenase; Belongs to the GcvP family. (949 aa) |
| | BVU_3260 | Lysine-sensitive aspartokinase III. (448 aa) |
| | dapA | Putative dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (303 aa) |
| | pyrK | Dihydroorotate dehydrogenase, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (259 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory chain; Involved in allosteric regulation of aspartate carbamoyltransferase. (155 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | BVU_3505 | Conserved hypothetical protein. (363 aa) |
| | BVU_3530 | Glutamine synthetase I. (500 aa) |
| | BVU_3551 | Ribose-phosphate pyrophosphokinase. (312 aa) |
| | BVU_3579 | Glutamine synthetase. (729 aa) |
| | guaA | Glutaminne-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. (517 aa) |
| | BVU_3588 | Putative GMP synthase. (435 aa) |
| | BVU_3604 | Putative proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydraogenase; Belongs to the aldehyde dehydrogenase family. (1144 aa) |
| | BVU_3640 | Putative NADPH-dependent glutamate synthase. (765 aa) |
| | BVU_3649 | Purine nucleoside phosphorylase II. (292 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (361 aa) |
| | BVU_3830 | Amidophosphoribosyltransferase precursor; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (468 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisA | Imidazole-4-carboxamide isomerase. (239 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (203 aa) |
| | BVU_3856 | Aspartokinase; Belongs to the aspartokinase family. (439 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (386 aa) |
| | BVU_3869 | Putative dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (324 aa) |
| | BVU_3895 | Glutamate decarboxylase; Belongs to the group II decarboxylase family. (482 aa) |
| | glsA-2 | Putative glutaminase; Belongs to the glutaminase family. (320 aa) |
| | BVU_3997 | Carbamyl phosphate synthetase. (1075 aa) |
| | carA | Glutamine-hydrolyzing carbamoyl phosphate synthetase III; Belongs to the CarA family. (358 aa) |
| | BVU_3999 | Putative phosphoribosylpyrophosphate amidotransferase. (627 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (614 aa) |
| | BVU_4001 | Glutamine synthetase. (729 aa) |
| | dapL | Aspartate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (409 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (280 aa) |
| | BVU_4007 | Glutamate synthase, large subunit. (1492 aa) |
| | BVU_4008 | Glutamate synthase, small subunit. (446 aa) |
| | BVU_4041 | Putative carbamoylphosphate synthase, large subunit. (330 aa) |
| | BVU_4042 | Diaminopimelate decarboxylase. (391 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa) |
| | BVU_4088 | Anthranilate synthase component I. (466 aa) |
| | BVU_4089 | Anthranilate synthase component II. (196 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (331 aa) |
| | BVU_4091 | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | trpF | Putative N-(5'-phosphoribosyl) anthranilate isomerase; Belongs to the TrpF family. (205 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (258 aa) |
