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| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa) |
| | Nmar_0136 | PFAM: oxidoreductase domain protein; KEGG: neu:NE1568 possible oxidoreductase. (348 aa) |
| | Nmar_0167 | Transcriptional regulator, RpiR family; PFAM: sugar isomerase (SIS); KEGG: csc:Csac_1187 bifunctional phosphoglucose/phosphomannose isomerase. (323 aa) |
| | Nmar_0170 | PFAM: oxidoreductase domain protein; KEGG: vvu:VV1_0802 predicted dehydrogenase. (328 aa) |
| | Nmar_0171 | PFAM: oxidoreductase domain protein; KEGG: pmb:A9601_13411 hypothetical protein. (305 aa) |
| | Nmar_0172 | PFAM: protein of unknown function DUF59; KEGG: dra:DR_2165 hypothetical protein. (212 aa) |
| | Nmar_0177 | PFAM: aminotransferase class I and II; KEGG: pab:PAB1810 aspartate aminotransferase (aspB-like2). (391 aa) |
| | Nmar_0181 | PFAM: Phosphoglycerate mutase; KEGG: sto:ST2120 hypothetical protein. (207 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa) |
| | Nmar_0193 | PFAM: aspartate/glutamate/uridylate kinase; KEGG: mka:MK0109 aspartokinase. (471 aa) |
| | Nmar_0214 | Dihydropyrimidinase; PFAM: amidohydrolase; KEGG: chy:CHY_0678 allantoinase. (464 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (133 aa) |
| | ilvE-2 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (305 aa) |
| | Nmar_0258 | KEGG: chy:CHY_1373 succinate dehydrogenase; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (570 aa) |
| | Nmar_0259 | KEGG: chy:CHY_1372 hypothetical protein. (143 aa) |
| | Nmar_0260 | KEGG: mse:Msed_1112 hypothetical protein. (114 aa) |
| | Nmar_0261 | KEGG: hbu:Hbut_0157 succinate dehydrogenase/fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein. (249 aa) |
| | Nmar_0272 | PFAM: carboxyl transferase; KEGG: tte:TTE2385 Acetyl-CoA carboxylase alpha subunit. (515 aa) |
| | Nmar_0273 | Carbamoyl-phosphate synthase L chain ATP-binding; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: msi:Msm_0765 pyruvate carboxylase (acetyl-CoA/biotin carboxylase), subunit A, PycA. (495 aa) |
| | Nmar_0274 | PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: mgi:Mflv_4784 carbamoyl-phosphate synthase L chain, ATP-binding. (170 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (201 aa) |
| | Nmar_0299 | PFAM: ribulose-phosphate 3-epimerase; Transketolase domain protein; KEGG: pth:PTH_2750 transketolase, N-terminal subunit. (555 aa) |
| | Nmar_0300 | PFAM: Transketolase central region; Transketolase domain protein; KEGG: drm:Dred_3074 transketolase, central region. (324 aa) |
| | tal | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (222 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (412 aa) |
| | mdh | Lactate/malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (304 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (499 aa) |
| | Nmar_0412 | Glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: mse:Msed_0256 glyoxylate reductase. (322 aa) |
| | Nmar_0413 | PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: sai:Saci_0209 2-oxoacid-ferredoxin oxidoreductase, alfa domain. (636 aa) |
| | Nmar_0414 | TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: tth:TTC1592 2-oxoacid-ferredoxin oxidoreductase. (320 aa) |
| | leuC | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
| | Nmar_0421 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: ckl:CKL_2158 LeuD. (160 aa) |
| | Nmar_0422 | KEGG: sth:STH2116 3-isopropylmalate dehydratase large subunit; TIGRFAM: 3-isopropylmalate dehydratase, large subunit; PFAM: aconitate hydratase domain protein. (471 aa) |
| | Nmar_0423 | KEGG: bsu:BG11950 3-isopropylmalate dehydratase small subunit; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein. (194 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: mja:MJ0641 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (408 aa) |
| | Nmar_0537 | Phosphoglycerate mutase; PFAM: metalloenzyme domain protein; KEGG: tpe:Tpen_1046 phosphonopyruvate decarboxylase-related protein. (428 aa) |
| | Nmar_0545 | PFAM: Prephenate dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: mba:Mbar_A0924 prephenate dehydrogenase. (283 aa) |
| | Nmar_0546 | PFAM: Chorismate mutase; aminotransferase class I and II; KEGG: tpt:Tpet_1516 aminotransferase, class I and II. (456 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (422 aa) |
| | aroK | TIGRFAM: shikimate kinase; PFAM: GHMP kinase; KEGG: mae:Maeo_0247 shikimate kinase. (284 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (223 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (353 aa) |
| | aroA-2 | Predicted phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (260 aa) |
| | purM | KEGG: msi:Msm_1039 phosphoribosylformylglycinamidine cyclo-ligase (AirS), PurM; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (340 aa) |
| | Nmar_0666 | KEGG: afu:AF2138 phosphoserine phosphatase (SerB); TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. (238 aa) |
| | Nmar_0676 | PFAM: Lactate/malate dehydrogenase; KEGG: cho:Chro.70063 lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (303 aa) |
| | Nmar_0696 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mja:MJ1602 homoserine dehydrogenase. (336 aa) |
| | Nmar_0701 | TIGRFAM: acetate--CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: deb:DehaBAV1_1019 acetate--CoA ligase. (638 aa) |
| | Nmar_0770 | PFAM: IMP biosynthesis enzyme PurP domain protein; IMP biosynthesis enzyme PurP; KEGG: iho:Igni_0943 IMP biosynthesis enzyme PurP-like protein. (363 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (86 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (228 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (721 aa) |
| | purF | Glutamine amidotransferase class-II; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (489 aa) |
| | purC | PFAM: SAICAR synthetase; KEGG: cjk:jk0350 phosphoribosylaminoimidazole-succinocarboxamide synthase. (274 aa) |
| | Nmar_0831 | Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating); PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: hal:VNG0095G glyceraldehyde 3-phosphate dehydrogenase. (350 aa) |
| | Nmar_0833 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (445 aa) |
| | Nmar_0841 | Propanoyl-CoA C-acyltransferase; PFAM: Thiolase; KEGG: tac:Ta0030 acetyl-CoA acyltransferase. (371 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (191 aa) |
| | Nmar_0848 | TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: chy:CHY_2459 threonine dehydratase. (402 aa) |
| | Nmar_0850 | PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: lpn:lpg1490 adenylate cyclase PLUS two component hybrid sensor and regulator. (278 aa) |
| | Nmar_0865 | PFAM: aminotransferase class I and II; KEGG: mhu:Mhun_1459 aminotransferase, class I and II. (452 aa) |
| | Nmar_0866 | PFAM: AMP-dependent synthetase and ligase; KEGG: afu:AF0975 acetyl-CoA synthetase (acs-4). (641 aa) |
| | purP | IMP biosynthesis enzyme PurP domain protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (341 aa) |
| | ilvD | KEGG: sto:ST2172 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (558 aa) |
| | Nmar_0911 | PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like; KEGG: mst:Msp_1070 TrpE. (449 aa) |
| | Nmar_0912 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cac:CAC3162 putative anthranilate synthase component II. (198 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | Nmar_0914 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: cth:Cthe_0872 indole-3-glycerol-phosphate synthase. (258 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa) |
| | Nmar_0922 | PFAM: PfkB domain protein; KEGG: smr:Smar_1352 hypothetical protein. (289 aa) |
| | Nmar_0935 | PFAM: asparagine synthase; KEGG: pis:Pisl_1452 asparagine synthase. (339 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (218 aa) |
| | Nmar_0953 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: tte:TTE2386 lactoylglutathione lyase and related lyases. (131 aa) |
| | Nmar_0954 | KEGG: tte:TTE1217 Methylmalonyl-CoA mutase, N-terminal domain/subunit; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase. (532 aa) |
| | Nmar_0955 | TIGRFAM: LAO/AO transport system ATPase; PFAM: ArgK protein; KEGG: pab:PAB2398 lysine arginine ornithine transport system kinase. (305 aa) |
| | Nmar_0956 | Hypothetical protein. (135 aa) |
| | Nmar_0957 | PFAM: Peptidase M1 membrane alanine aminopeptidase; KEGG: mmu:19155 aminopeptidase puromycin sensitive. (830 aa) |
| | Nmar_0958 | PFAM: cobalamin B12-binding domain protein; KEGG: tte:TTE2388 methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding). (140 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | Nmar_1008 | D-alanine--D-alanine ligase; PFAM: peptidase M20; protein of unknown function DUF201; D-alanine--D-alanine ligase domain protein; RimK domain protein ATP-grasp; KEGG: amt:Amet_3744 D-alanine--D-alanine ligase domain protein. (743 aa) |
| | Nmar_1028 | PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: sai:Saci_1134 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase; K00022 3-hydroxyacyl-CoA dehydrogenase; K01692 enoyl-CoA hydratase. (379 aa) |
| | fbp | Protein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (381 aa) |
| | Nmar_1069 | KEGG: sso:SSO0723 3-isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (337 aa) |
| | Nmar_1070 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mka:MK0391 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa) |
| | Nmar_1071 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mja:MJ0161 acetolactate synthase small subunit. (161 aa) |
| | Nmar_1072 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pfu:PF0935 acetolactate synthase large subunit. (566 aa) |
| | Nmar_1085 | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: bvu:BVU_3997 carbamyl phosphate synthetase. (1080 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: pfu:PF1713 carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (384 aa) |
| | Nmar_1099 | KEGG: sfu:Sfum_2105 citrate (Si)-synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase. (387 aa) |
| | Nmar_1111 | Hydroxypyruvate reductase; PFAM: MOFRL domain protein; KEGG: pfu:PF0024 putative glycerate kinase. (425 aa) |
| | Nmar_1114 | TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein; KEGG: gme:Gmet_1845 phosphoribosylglycinamide formyltransferase. (191 aa) |
| | purD | KEGG: cbd:COXBU7E912_1753 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; ATP-grasp domain protein; Belongs to the GARS family. (421 aa) |
| | Nmar_1123 | Succinate--CoA ligase (ADP-forming); PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein; KEGG: iho:Igni_0086 succinyl-CoA synthetase (ADP-forming) beta subunit. (368 aa) |
| | sucD | CoA-binding domain protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (305 aa) |
| | nadX | Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (272 aa) |
| | Nmar_1258 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: pho:PH1387 phosphoglycerate dehydrogenase. (310 aa) |
| | Nmar_1260 | PFAM: fumarate lyase; KEGG: aba:Acid345_2689 fumarate lyase. (453 aa) |
| | Nmar_1261 | MiaB-like tRNA modifying enzyme; KEGG: pab:PAB1134 hypothetical protein; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: deoxyribonuclease/rho motif-related TRAM; Radical SAM domain protein; Protein of unknown function UPF0004; SMART: Elongator protein 3/MiaB/NifB. (422 aa) |
| | Nmar_1262 | PFAM: Tubulin/FtsZ GTPase; KEGG: mka:MK0821 ftsZ GTPase involved in cell division. (316 aa) |
| | Nmar_1293 | PFAM: pyruvate carboxyltransferase; KEGG: mka:MK1209 2-isopropylmalate synthase. (393 aa) |
| | Nmar_1308 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: tte:TTE0544 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (253 aa) |
| | Nmar_1379 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mma:MM_1003 isocitrate dehydrogenase [NADP]. (343 aa) |
| | Nmar_1389 | PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: rci:LRC391 predicted dihydroorotate dehydrogenase, electron transfer subunit. (270 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (303 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa) |
| | Nmar_1418 | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: mma:MM_2083 orotidine 5'-phosphate decarboxylase. (246 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (333 aa) |
| | Nmar_1455 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mja:MJ0929 adenylosuccinate lyase. (453 aa) |
| | Nmar_1466 | PFAM: asparagine synthase; KEGG: mth:MTH414 asparagine synthetase. (251 aa) |
| | Nmar_1482 | Aconitate hydratase; KEGG: bba:Bd2784 3-isopropylmalate isomerase; TIGRFAM: aconitate hydratase; PFAM: aconitate hydratase domain protein. (754 aa) |
| | Nmar_1535 | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (182 aa) |
| | Nmar_1549 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (404 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (108 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (266 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase; PFAM: histidine biosynthesis protein; KEGG: ckl:CKL_1299 HisA. (236 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (200 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: hne:HNE_0073 imidazoleglycerol phosphate dehydratase. (195 aa) |
| | Nmar_1556 | PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: nph:NP0770A hypothetical protein. (306 aa) |
| | Nmar_1557 | PFAM: aminotransferase class I and II; KEGG: amt:Amet_0573 histidinol-phosphate aminotransferase. (356 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (420 aa) |
| | Nmar_1559 | KEGG: mtp:Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase; PFAM: Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region. (325 aa) |
| | Nmar_1561 | PFAM: glucose sorbosone dehydrogenase; KEGG: bha:BH2090 glucose dehydrogenase-B. (363 aa) |
| | Nmar_1567 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: det:DET0461 chorismate mutase / prephenate dehydratase. (271 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (476 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (507 aa) |
| | ade | Adenine deaminase; PFAM: amidohydrolase; KEGG: cbf:CLI_0367 adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (571 aa) |
| | Nmar_1586 | KEGG: mxa:MXAN_3050 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region. (358 aa) |
| | Nmar_1608 | PFAM: aldehyde dehydrogenase; KEGG: mbu:Mbur_0175 succinate-semialdehyde dehydrogenase (NAD(P)+). (443 aa) |
| | Nmar_1621 | Citryl-CoA lyase; PFAM: HpcH/HpaI aldolase; KEGG: mta:Moth_0400 citrate lyase. (284 aa) |
| | Nmar_1622 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: sus:Acid_2440 alcohol dehydrogenase, zinc-binding domain protein. (358 aa) |
| | Nmar_1627 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (884 aa) |
| | Nmar_1628 | SMART: regulatory protein ArsR; KEGG: mvn:Mevan_1241 anaerobic ribonucleoside-triphosphate reductase. (723 aa) |
| | Nmar_1630 | PFAM: protein of unknown function DUF35; KEGG: sai:Saci_2291 conserved archaeal protein. (128 aa) |
| | Nmar_1631 | Propanoyl-CoA C-acyltransferase; PFAM: Thiolase; KEGG: gur:Gura_4354 thiolase. (387 aa) |
| | pyrB | KEGG: pho:PH0720 aspartate carbamoyltransferase catalytic chain; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain. (309 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (153 aa) |
| | pyrH | Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. (227 aa) |
| | Nmar_1706 | PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: aae:aq_1910 hypothetical protein. (411 aa) |
| | tmk | PFAM: thymidylate kinase; KEGG: ehi:55.t00018 thymidylate kinase, putative. (193 aa) |
| | Nmar_1708 | PFAM: heat shock protein Hsp20; KEGG: mse:Msed_1294 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (126 aa) |
| | Nmar_1754 | KEGG: mka:MK0109 aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (467 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (440 aa) |
