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thrB thrB Nmar_0177 Nmar_0177 ilvE ilvE Nmar_0193 Nmar_0193 ilvE-2 ilvE-2 leuC leuC Nmar_0421 Nmar_0421 Nmar_0422 Nmar_0422 Nmar_0423 Nmar_0423 Nmar_0696 Nmar_0696 Nmar_0833 Nmar_0833 Nmar_0848 Nmar_0848 ilvD ilvD ilvC ilvC Nmar_1069 Nmar_1069 Nmar_1070 Nmar_1070 Nmar_1071 Nmar_1071 Nmar_1072 Nmar_1072 Nmar_1293 Nmar_1293 Nmar_1549 Nmar_1549 Nmar_1586 Nmar_1586 Nmar_1754 Nmar_1754
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa)
Nmar_0177PFAM: aminotransferase class I and II; KEGG: pab:PAB1810 aspartate aminotransferase (aspB-like2). (391 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa)
Nmar_0193PFAM: aspartate/glutamate/uridylate kinase; KEGG: mka:MK0109 aspartokinase. (471 aa)
ilvE-2Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (305 aa)
leuC3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa)
Nmar_0421TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: ckl:CKL_2158 LeuD. (160 aa)
Nmar_0422KEGG: sth:STH2116 3-isopropylmalate dehydratase large subunit; TIGRFAM: 3-isopropylmalate dehydratase, large subunit; PFAM: aconitate hydratase domain protein. (471 aa)
Nmar_0423KEGG: bsu:BG11950 3-isopropylmalate dehydratase small subunit; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein. (194 aa)
Nmar_0696PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mja:MJ1602 homoserine dehydrogenase. (336 aa)
Nmar_0833Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (445 aa)
Nmar_0848TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: chy:CHY_2459 threonine dehydratase. (402 aa)
ilvDKEGG: sto:ST2172 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (558 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
Nmar_1069KEGG: sso:SSO0723 3-isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (337 aa)
Nmar_1070TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mka:MK0391 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa)
Nmar_1071TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mja:MJ0161 acetolactate synthase small subunit. (161 aa)
Nmar_1072TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: pfu:PF0935 acetolactate synthase large subunit. (566 aa)
Nmar_1293PFAM: pyruvate carboxyltransferase; KEGG: mka:MK1209 2-isopropylmalate synthase. (393 aa)
Nmar_1549Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (404 aa)
Nmar_1586KEGG: mxa:MXAN_3050 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region. (358 aa)
Nmar_1754KEGG: mka:MK0109 aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (467 aa)
Your Current Organism:
Nitrosopumilus maritimus
NCBI taxonomy Id: 436308
Other names: N. maritimus SCM1, Nitrosopumilus maritimus SCM1, Nitrosopumilus maritimus str. SCM1, Nitrosopumilus maritimus strain SCM1, Seattle Aquarium strain SCM1
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