node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Nmar_1559 | apt | Nmar_1559 | Nmar_1400 | KEGG: mtp:Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase; PFAM: Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.470 |
Nmar_1559 | hisF | Nmar_1559 | Nmar_1552 | KEGG: mtp:Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase; PFAM: Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
Nmar_1559 | hisH | Nmar_1559 | Nmar_1554 | KEGG: mtp:Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase; PFAM: Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
Nmar_1559 | purF | Nmar_1559 | Nmar_0781 | KEGG: mtp:Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase; PFAM: Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region. | Glutamine amidotransferase class-II; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.550 |
Nmar_1559 | trpD | Nmar_1559 | Nmar_0913 | KEGG: mtp:Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase; PFAM: Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.550 |
apt | Nmar_1559 | Nmar_1400 | Nmar_1559 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | KEGG: mtp:Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase; PFAM: Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region. | 0.470 |
apt | hisF | Nmar_1400 | Nmar_1552 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.841 |
apt | hisH | Nmar_1400 | Nmar_1554 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.806 |
apt | mtnP | Nmar_1400 | Nmar_1401 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.998 |
apt | purF | Nmar_1400 | Nmar_0781 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamine amidotransferase class-II; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.625 |
apt | pyrE | Nmar_1400 | Nmar_0289 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.575 |
apt | trpD | Nmar_1400 | Nmar_0913 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.461 |
hisF | Nmar_1559 | Nmar_1552 | Nmar_1559 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | KEGG: mtp:Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase; PFAM: Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region. | 0.999 |
hisF | apt | Nmar_1552 | Nmar_1400 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.841 |
hisF | hisH | Nmar_1552 | Nmar_1554 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisF | trpD | Nmar_1552 | Nmar_0913 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.473 |
hisH | Nmar_1559 | Nmar_1554 | Nmar_1559 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | KEGG: mtp:Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase; PFAM: Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region. | 0.999 |
hisH | apt | Nmar_1554 | Nmar_1400 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.806 |
hisH | hisF | Nmar_1554 | Nmar_1552 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisH | trpD | Nmar_1554 | Nmar_0913 | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.434 |