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| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (421 aa) |
| | mtnP | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (263 aa) |
| | Nmar_1379 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: mma:MM_1003 isocitrate dehydrogenase [NADP]. (343 aa) |
| | Nmar_1331 | TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease; KEGG: csc:Csac_2764 ParB-like partition protein. (269 aa) |
| | Nmar_1310 | PFAM: glutamine amidotransferase class-I; KEGG: tpt:Tpet_1592 glutamine amidotransferase class-I. (227 aa) |
| | lysK | N-acetyl-ornithine/N-acetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (375 aa) |
| | Nmar_1295 | Lysine biosynthesis enzyme LysX; TIGRFAM: alpha-L-glutamate ligase, RimK family; lysine biosynthesis enzyme LysX; PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: pto:PTO1469 RimK-like protein. (280 aa) |
| | Nmar_1294 | KEGG: iho:Igni_1402 hypothetical protein. (55 aa) |
| | Nmar_1293 | PFAM: pyruvate carboxyltransferase; KEGG: mka:MK1209 2-isopropylmalate synthase. (393 aa) |
| | lysJ | Acetylornithine and succinylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (393 aa) |
| | lysZ | Acetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (267 aa) |
| | lysY | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (348 aa) |
| | Nmar_1288 | Lysine biosynthesis enzyme LysX; TIGRFAM: alpha-L-glutamate ligase, RimK family; lysine biosynthesis enzyme LysX; PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: nph:NP5258A probable arginine biosynthesis regulator (lysine biosynthesis regulator LysX homolog). (285 aa) |
| | Nmar_1287 | KEGG: iho:Igni_1402 hypothetical protein. (55 aa) |
| | argG | PFAM: argininosuccinate synthase; ExsB family protein; KEGG: pfu:PF0207 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa) |
| | Nmar_1268 | PFAM: homocysteine S-methyltransferase; KEGG: afw:Anae109_0087 methionine synthase. (320 aa) |
| | Nmar_1258 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: pho:PH1387 phosphoglycerate dehydrogenase. (310 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (318 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: pfu:PF1713 carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (384 aa) |
| | Nmar_1085 | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: bvu:BVU_3997 carbamyl phosphate synthetase. (1080 aa) |
| | Nmar_1071 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: mja:MJ0161 acetolactate synthase small subunit. (161 aa) |
| | Nmar_1070 | TIGRFAM: isopropylmalate/citramalate/homocitrate synthase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: mka:MK0391 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (505 aa) |
| | Nmar_1069 | KEGG: sso:SSO0723 3-isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. (337 aa) |
| | Nmar_1008 | D-alanine--D-alanine ligase; PFAM: peptidase M20; protein of unknown function DUF201; D-alanine--D-alanine ligase domain protein; RimK domain protein ATP-grasp; KEGG: amt:Amet_3744 D-alanine--D-alanine ligase domain protein. (743 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | Nmar_0935 | PFAM: asparagine synthase; KEGG: pis:Pisl_1452 asparagine synthase. (339 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (395 aa) |
| | Nmar_0914 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: cth:Cthe_0872 indole-3-glycerol-phosphate synthase. (258 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | Nmar_0911 | PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like; KEGG: mst:Msp_1070 TrpE. (449 aa) |
| | ilvD | KEGG: sto:ST2172 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (558 aa) |
| | Nmar_0848 | TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: chy:CHY_2459 threonine dehydratase. (402 aa) |
| | Nmar_0831 | Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating); PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: hal:VNG0095G glyceraldehyde 3-phosphate dehydrogenase. (350 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (228 aa) |
| | Nmar_0822 | PFAM: aminotransferase class-III; KEGG: sae:NWMN_2325 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (326 aa) |
| | Nmar_0819 | 8-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; KEGG: tac:Ta1189 8-amino-7-oxononanoate synthase. (374 aa) |
| | Nmar_0696 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: mja:MJ1602 homoserine dehydrogenase. (336 aa) |
| | Nmar_0692 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: rrs:RoseRS_2549 peptidase M20. (450 aa) |
| | Nmar_0670 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: pth:PTH_2596 cysteine synthase. (330 aa) |
| | Nmar_0666 | KEGG: afu:AF2138 phosphoserine phosphatase (SerB); TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. (238 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family. (353 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (223 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa) |
| | aroK | TIGRFAM: shikimate kinase; PFAM: GHMP kinase; KEGG: mae:Maeo_0247 shikimate kinase. (284 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (422 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | Nmar_0545 | PFAM: Prephenate dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: mba:Mbar_A0924 prephenate dehydrogenase. (283 aa) |
| | Nmar_0493 | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: sat:SYN_02272 uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase. (267 aa) |
| | Nmar_0423 | KEGG: bsu:BG11950 3-isopropylmalate dehydratase small subunit; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein. (194 aa) |
| | Nmar_0422 | KEGG: sth:STH2116 3-isopropylmalate dehydratase large subunit; TIGRFAM: 3-isopropylmalate dehydratase, large subunit; PFAM: aconitate hydratase domain protein. (471 aa) |
| | Nmar_0421 | TIGRFAM: 3-isopropylmalate dehydratase, small subunit; PFAM: aconitate hydratase domain protein; KEGG: ckl:CKL_2158 LeuD. (160 aa) |
| | leuC | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
| | Nmar_0397 | TIGRFAM: ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: pho:PH0726 ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (304 aa) |
| | argH | KEGG: mtp:Mthe_0492 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (485 aa) |
| | ilvE-2 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (305 aa) |
| | Nmar_0245 | Acetyltransferase; KEGG: hbu:Hbut_1414 predicted acetyltransferase. (158 aa) |
| | Nmar_0193 | PFAM: aspartate/glutamate/uridylate kinase; KEGG: mka:MK0109 aspartokinase. (471 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa) |
| | Nmar_0169 | Putative translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (345 aa) |
| | Nmar_0140 | PFAM: pyruvate carboxyltransferase; KEGG: mla:Mlab_0987 hypothetical protein. (352 aa) |
| | Nmar_0138 | PFAM: 4'-phosphopantetheinyl transferase; KEGG: mbn:Mboo_1740 holo-acyl-carrier-protein synthase. (115 aa) |
| | Nmar_0044 | PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bat:BAS4042 oxidoreductase, short-chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa) |
| | Nmar_1731 | Serine--pyruvate transaminase; PFAM: aminotransferase class V; KEGG: mvn:Mevan_1378 serine--pyruvate transaminase. (381 aa) |
| | Nmar_1754 | KEGG: mka:MK0109 aspartokinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (467 aa) |
| | Nmar_1771 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: sto:ST1387 glutamine synthetase. (481 aa) |
| | Nmar_1790 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: mse:Msed_1612 glutamine synthetase, type I. (490 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (440 aa) |
| | Nmar_1466 | PFAM: asparagine synthase; KEGG: mth:MTH414 asparagine synthetase. (251 aa) |
| | Nmar_1517 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cne:CNL05880 cysteine synthase. (514 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (108 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (266 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase; PFAM: histidine biosynthesis protein; KEGG: ckl:CKL_1299 HisA. (236 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (200 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: hne:HNE_0073 imidazoleglycerol phosphate dehydratase. (195 aa) |
| | Nmar_1557 | PFAM: aminotransferase class I and II; KEGG: amt:Amet_0573 histidinol-phosphate aminotransferase. (356 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (420 aa) |
| | Nmar_1559 | KEGG: mtp:Mthe_0080 ATP phosphoribosyltransferase; TIGRFAM: ATP phosphoribosyltransferase; PFAM: Histidine biosynthesis protein HisG domain; ATP phosphoribosyltransferase catalytic region. (325 aa) |
| | Nmar_1567 | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: det:DET0461 chorismate mutase / prephenate dehydratase. (271 aa) |
| | Nmar_1585 | PFAM: aminotransferase class I and II; KEGG: cbe:Cbei_1269 putative L-threonine-O-3-phosphate decarboxylase. (359 aa) |
| | Nmar_1586 | KEGG: mxa:MXAN_3050 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region. (358 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (279 aa) |
