(15 nodes) RNA polymerase II, core complex, and TFIIS/LEDGF domain superfamily network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_1050p93	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1454 aa)
	Kpol_1050p110	Uncharacterized protein. (153 aa)
	Kpol_1039p73	TFIIS N-terminal domain-containing protein. (411 aa)
	Kpol_1033p49	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (122 aa)
	Kpol_1037p21	RNA_pol_L_2 domain-containing protein. (120 aa)
	Kpol_1060p55	RPOL4c domain-containing protein. (221 aa)
	Kpol_1059p24	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (146 aa)
	Kpol_1053p17	RTR1-type domain-containing protein. (225 aa)
	Kpol_1026p15	Uncharacterized protein. (323 aa)
	Kpol_1019p27	RNA_pol_Rpb1_1 domain-containing protein. (364 aa)
	Kpol_472p12	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (103 aa)
	Kpol_1068p9	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (745 aa)
	Kpol_186p2	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1223 aa)
	Kpol_186p3	Uncharacterized protein. (171 aa)
	Kpol_162p1	RPOLA_N domain-containing protein. (1311 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kpol_1019p27	Kpol_1026p15	A7TPB9	A7TNI5	RNA_pol_Rpb1_1 domain-containing protein.	Uncharacterized protein.	0.925
Kpol_1019p27	Kpol_1033p49	A7TPB9	A7TJ44	RNA_pol_Rpb1_1 domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.954
Kpol_1019p27	Kpol_1037p21	A7TPB9	A7TJW3	RNA_pol_Rpb1_1 domain-containing protein.	RNA_pol_L_2 domain-containing protein.	0.954
Kpol_1019p27	Kpol_1039p73	A7TPB9	A7THK0	RNA_pol_Rpb1_1 domain-containing protein.	TFIIS N-terminal domain-containing protein.	0.754
Kpol_1019p27	Kpol_1050p110	A7TPB9	A7TF04	RNA_pol_Rpb1_1 domain-containing protein.	Uncharacterized protein.	0.954
Kpol_1019p27	Kpol_1050p93	A7TPB9	A7TEY7	RNA_pol_Rpb1_1 domain-containing protein.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.897
Kpol_1019p27	Kpol_1053p17	A7TPB9	A7TN62	RNA_pol_Rpb1_1 domain-containing protein.	RTR1-type domain-containing protein.	0.865
Kpol_1019p27	Kpol_1059p24	A7TPB9	A7TN28	RNA_pol_Rpb1_1 domain-containing protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.954
Kpol_1019p27	Kpol_1060p55	A7TPB9	A7TK52	RNA_pol_Rpb1_1 domain-containing protein.	RPOL4c domain-containing protein.	0.954
Kpol_1019p27	Kpol_1068p9	A7TPB9	A7TSR4	RNA_pol_Rpb1_1 domain-containing protein.	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	0.940
Kpol_1019p27	Kpol_162p1	A7TPB9	A7TTU2	RNA_pol_Rpb1_1 domain-containing protein.	RPOLA_N domain-containing protein.	0.934
Kpol_1019p27	Kpol_186p2	A7TPB9	A7TTM7	RNA_pol_Rpb1_1 domain-containing protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.967
Kpol_1019p27	Kpol_186p3	A7TPB9	A7TTM8	RNA_pol_Rpb1_1 domain-containing protein.	Uncharacterized protein.	0.955
Kpol_1019p27	Kpol_472p12	A7TPB9	A7TQI0	RNA_pol_Rpb1_1 domain-containing protein.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.952
Kpol_1026p15	Kpol_1019p27	A7TNI5	A7TPB9	Uncharacterized protein.	RNA_pol_Rpb1_1 domain-containing protein.	0.925
Kpol_1026p15	Kpol_1033p49	A7TNI5	A7TJ44	Uncharacterized protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.997
Kpol_1026p15	Kpol_1037p21	A7TNI5	A7TJW3	Uncharacterized protein.	RNA_pol_L_2 domain-containing protein.	0.993
Kpol_1026p15	Kpol_1039p73	A7TNI5	A7THK0	Uncharacterized protein.	TFIIS N-terminal domain-containing protein.	0.986
Kpol_1026p15	Kpol_1050p110	A7TNI5	A7TF04	Uncharacterized protein.	Uncharacterized protein.	0.989
Kpol_1026p15	Kpol_1050p93	A7TNI5	A7TEY7	Uncharacterized protein.	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family.	0.992