STRINGSTRING
Kpol_1018p37 Kpol_1018p37 Kpol_1036p63 Kpol_1036p63 NCS6 NCS6 Kpol_1050p33 Kpol_1050p33 Kpol_1023p89 Kpol_1023p89 Kpol_1028p17 Kpol_1028p17 NCS2 NCS2 Kpol_1048p40 Kpol_1048p40 Kpol_1048p60 Kpol_1048p60 Kpol_1013p15 Kpol_1013p15 UBA4 UBA4 Kpol_534p13 Kpol_534p13 Kpol_1058p44 Kpol_1058p44 Kpol_1060p2 Kpol_1060p2 Kpol_1024p28 Kpol_1024p28 Kpol_1024p43 Kpol_1024p43 Kpol_1003p13 Kpol_1003p13 Kpol_513p13 Kpol_513p13 Kpol_483p13 Kpol_483p13 URM1 URM1 Kpol_467p14 Kpol_467p14 Kpol_1076p1 Kpol_1076p1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Kpol_1018p37ThiF domain-containing protein. (439 aa)
Kpol_1036p63MTS domain-containing protein. (220 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (363 aa)
Kpol_1050p33Uncharacterized protein. (788 aa)
Kpol_1023p89Methyltransf_11 domain-containing protein. (270 aa)
Kpol_1028p17Uncharacterized protein. (134 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (485 aa)
Kpol_1048p40Uncharacterized protein. (483 aa)
Kpol_1048p60GCR1_C domain-containing protein. (949 aa)
Kpol_1013p15Sulfurtransferase. (302 aa)
UBA4Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...] (436 aa)
Kpol_534p13RF_PROK_I domain-containing protein. (404 aa)
Kpol_1058p44PseudoU_synth_1 domain-containing protein. (446 aa)
Kpol_1060p2Uncharacterized protein. (271 aa)
Kpol_1024p28Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (559 aa)
Kpol_1024p43Uncharacterized protein. (544 aa)
Kpol_1003p13MTS domain-containing protein. (324 aa)
Kpol_513p13Uncharacterized protein. (303 aa)
Kpol_483p13Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1331 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (103 aa)
Kpol_467p14Uncharacterized protein. (310 aa)
Kpol_1076p1UPF0020 domain-containing protein. (438 aa)
Your Current Organism:
Vanderwaltozyma polyspora
NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294
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