(58 nodes) Ribonucleoprotein granule, and CCR4-NOT core complex network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_1018p122	Uncharacterized protein. (634 aa)
	Kpol_1002p69	Uncharacterized protein. (590 aa)
	Kpol_1002p116	Uncharacterized protein. (452 aa)
	Kpol_1036p18	eRF1_1 domain-containing protein. (440 aa)
	Kpol_1036p96	Nudix hydrolase domain-containing protein. (332 aa)
	Kpol_1036p104	Tr-type G domain-containing protein. (687 aa)
	Kpol_2002p88	LsmAD domain-containing protein. (754 aa)
	Kpol_1028p8	Uncharacterized protein. (427 aa)
	Kpol_1028p15	Uncharacterized protein. (2019 aa)
	Kpol_1048p12	AD domain-containing protein. (192 aa)
	Kpol_1048p23	Nudix hydrolase domain-containing protein. (835 aa)
	DHH1	ATP-dependent RNA helicase DHH1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (484 aa)
	Kpol_1032p49	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (580 aa)
	Kpol_1013p51	RRM domain-containing protein. (417 aa)
	Kpol_1039p77	Uncharacterized protein. (333 aa)
	Kpol_543p68	ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (335 aa)
	Kpol_1043p34	Uncharacterized protein. (442 aa)
	Kpol_1043p60	Uncharacterized protein. (706 aa)
	Kpol_541p40	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1521 aa)
	Kpol_1033p12	Uncharacterized protein. (143 aa)
	Kpol_1033p30	USP domain-containing protein. (1168 aa)
	Kpol_534p35	Uncharacterized protein. (482 aa)
	Kpol_1037p44	Nudix hydrolase domain-containing protein. (218 aa)
	TIF1	ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (396 aa)
	DED1	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (650 aa)
	Kpol_530p34	NOT2_3_5 domain-containing protein. (191 aa)
	Kpol_1041p43	MIF4G domain-containing protein. (900 aa)
	Kpol_1056p31	Uncharacterized protein. (576 aa)
	Kpol_513p3	INCENP_ARK-bind domain-containing protein. (798 aa)
	Kpol_1066p37	Uncharacterized protein. (399 aa)
	Kpol_1053p12	Smg4_UPF3 domain-containing protein. (399 aa)
	Kpol_1014p22	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (200 aa)
	Kpol_1014p33	Uncharacterized protein. (203 aa)
	Kpol_1026p25	MIF4G domain-containing protein. (843 aa)
	Kpol_1070p25	NOT2_3_5 domain-containing protein. (401 aa)
	Kpol_480p12	Uncharacterized protein. (1114 aa)
	Kpol_1009p25	Uncharacterized protein. (127 aa)
	Kpol_1057p18	C3H1-type domain-containing protein. (440 aa)
	Kpol_1040p14	Endo/exonuclease/phosphatase domain-containing protein. (784 aa)
	Kpol_1000p19	Nudix hydrolase domain-containing protein. (344 aa)
	Kpol_1008p23	Uncharacterized protein. (660 aa)
	Kpol_1006p7	Uncharacterized protein. (540 aa)
	Kpol_1006p9	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1292 aa)
	Kpol_472p18	DUF2439 domain-containing protein. (343 aa)
	RRT5	Regulator of rDNA transcription protein 5; May be involved in the modulation of rDNA transcription. (333 aa)
	Kpol_1038p18	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (210 aa)
	Kpol_458p1	Uncharacterized protein. (1751 aa)
	Kpol_1046p14	Helicase ATP-binding domain-containing protein. (1115 aa)
	Kpol_411p17	Uncharacterized protein. (636 aa)
	Kpol_400p1	RRM domain-containing protein. (600 aa)
	Kpol_400p3	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (240 aa)
	Kpol_376p3	SurE domain-containing protein. (730 aa)
	Kpol_364p2	Uncharacterized protein. (1067 aa)
	Kpol_1075p1a	Uncharacterized protein. (264 aa)
	Kpol_1068p5	Uncharacterized protein. (548 aa)
	Kpol_322p7	Uncharacterized protein. (534 aa)
	Kpol_337p1	AAA domain-containing protein. (999 aa)
	HEK2	Heterogeneous nuclear rnp K-like protein 2; RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus (By similarity). (336 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DED1	DHH1	A7TKR8	A7TGU7	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	ATP-dependent RNA helicase DHH1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.	0.770
DED1	Kpol_1008p23	A7TKR8	A7TPY7	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.500
DED1	Kpol_1013p51	A7TKR8	A7TH98	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	RRM domain-containing protein.	0.631
DED1	Kpol_1014p22	A7TKR8	A7TNF0	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.742
DED1	Kpol_1014p33	A7TKR8	A7TNG0	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.462
DED1	Kpol_1018p122	A7TKR8	A7TDW6	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.500
DED1	Kpol_1026p25	A7TKR8	A7TNJ4	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	MIF4G domain-containing protein.	0.666
DED1	Kpol_1032p49	A7TKR8	A7TH03	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.500
DED1	Kpol_1038p18	A7TKR8	A7TR08	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.742
DED1	Kpol_1039p77	A7TKR8	A7THK4	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.603
DED1	Kpol_1041p43	A7TKR8	A7TLB0	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	MIF4G domain-containing protein.	0.666
DED1	Kpol_1048p23	A7TKR8	A7TGI6	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Nudix hydrolase domain-containing protein.	0.461
DED1	Kpol_1053p12	A7TKR8	A7TN58	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Smg4_UPF3 domain-containing protein.	0.463
DED1	Kpol_1056p31	A7TKR8	A7TLN8	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.581
DED1	Kpol_1075p1a	A7TKR8	A7TSM7	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.500
DED1	Kpol_322p7	A7TKR8	A7TSY1	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.499
DED1	Kpol_337p1	A7TKR8	A7TT23	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	AAA domain-containing protein.	0.480
DED1	Kpol_400p3	A7TKR8	A7TRU2	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.	0.438
DED1	Kpol_513p3	A7TKR8	A7TMI9	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	INCENP_ARK-bind domain-containing protein.	0.476
DED1	TIF1	A7TKR8	A7TK55	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).	0.669