(12 nodes) Mixed, incl. Eukaryotic translation initiation factor 4F complex, and mRNA localization resulting in post-transcriptional regulation of gene expression network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_1018p122	Uncharacterized protein. (634 aa)
	Kpol_1013p51	RRM domain-containing protein. (417 aa)
	TIF1	ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (396 aa)
	DED1	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (650 aa)
	Kpol_1041p43	MIF4G domain-containing protein. (900 aa)
	Kpol_513p3	INCENP_ARK-bind domain-containing protein. (798 aa)
	Kpol_1014p22	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (200 aa)
	Kpol_1026p25	MIF4G domain-containing protein. (843 aa)
	Kpol_1008p23	Uncharacterized protein. (660 aa)
	Kpol_1038p18	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (210 aa)
	Kpol_1075p1a	Uncharacterized protein. (264 aa)
	Kpol_322p7	Uncharacterized protein. (534 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DED1	Kpol_1008p23	A7TKR8	A7TPY7	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.500
DED1	Kpol_1013p51	A7TKR8	A7TH98	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	RRM domain-containing protein.	0.631
DED1	Kpol_1014p22	A7TKR8	A7TNF0	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.742
DED1	Kpol_1018p122	A7TKR8	A7TDW6	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.500
DED1	Kpol_1026p25	A7TKR8	A7TNJ4	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	MIF4G domain-containing protein.	0.666
DED1	Kpol_1038p18	A7TKR8	A7TR08	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.742
DED1	Kpol_1041p43	A7TKR8	A7TLB0	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	MIF4G domain-containing protein.	0.666
DED1	Kpol_1075p1a	A7TKR8	A7TSM7	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.500
DED1	Kpol_322p7	A7TKR8	A7TSY1	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	Uncharacterized protein.	0.499
DED1	Kpol_513p3	A7TKR8	A7TMI9	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	INCENP_ARK-bind domain-containing protein.	0.476
DED1	TIF1	A7TKR8	A7TK55	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).	0.669
Kpol_1008p23	DED1	A7TPY7	A7TKR8	Uncharacterized protein.	ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.	0.500
Kpol_1008p23	Kpol_1013p51	A7TPY7	A7TH98	Uncharacterized protein.	RRM domain-containing protein.	0.678
Kpol_1008p23	Kpol_1014p22	A7TPY7	A7TNF0	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.678
Kpol_1008p23	Kpol_1026p25	A7TPY7	A7TNJ4	Uncharacterized protein.	MIF4G domain-containing protein.	0.724
Kpol_1008p23	Kpol_1038p18	A7TPY7	A7TR08	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.678
Kpol_1008p23	Kpol_1041p43	A7TPY7	A7TLB0	Uncharacterized protein.	MIF4G domain-containing protein.	0.724
Kpol_1008p23	Kpol_322p7	A7TPY7	A7TSY1	Uncharacterized protein.	Uncharacterized protein.	0.628
Kpol_1008p23	Kpol_513p3	A7TPY7	A7TMI9	Uncharacterized protein.	INCENP_ARK-bind domain-containing protein.	0.645
Kpol_1008p23	TIF1	A7TPY7	A7TK55	Uncharacterized protein.	ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).	0.761