(36 nodes) Mixed, incl. Homologous recombination, and Endodeoxyribonuclease activity network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_1018p31	Uncharacterized protein. (1332 aa)
	Kpol_1018p90	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (385 aa)
	Kpol_1018p126	AA_TRNA_LIGASE_II domain-containing protein. (554 aa)
	Kpol_1018p159	Ku domain-containing protein. (629 aa)
	Kpol_1036p43	RECA_2 domain-containing protein. (460 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (680 aa)
	Kpol_1050p80	Uncharacterized protein. (1505 aa)
	Kpol_2000p34	Zinc-hook domain-containing protein. (1305 aa)
	Kpol_2002p67	Uncharacterized protein. (116 aa)
	Kpol_1023p71	Uncharacterized protein. (601 aa)
	Kpol_1055p88	Uncharacterized protein. (182 aa)
	Kpol_1032p7	DNA ligase. (965 aa)
	Kpol_1032p38	RECA_2 domain-containing protein. (422 aa)
	Kpol_1045p22	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2767 aa)
	Kpol_541p31	Uncharacterized protein. (941 aa)
	Kpol_1025p37	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (618 aa)
	Kpol_1052p39	Uncharacterized protein; Belongs to the RecA family. (334 aa)
	Kpol_1053p32	Uncharacterized protein. (614 aa)
	Kpol_499p29	NTF2 domain-containing protein. (125 aa)
	Kpol_483p12	DNA repair protein RAD59; Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA. (203 aa)
	Kpol_458p5	Uncharacterized protein. (1022 aa)
	Kpol_440p9	ERCC4 domain-containing protein. (620 aa)
	Kpol_413p14	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (693 aa)
	Kpol_1071p14	Helicase ATP-binding domain-containing protein. (483 aa)
	Kpol_1007p11	ERCC4 domain-containing protein. (1062 aa)
	Kpol_1007p13	RMI1_N domain-containing protein. (248 aa)
	TVP18	Golgi apparatus membrane protein TVP18; Golgi membrane protein involved in vesicular trafficking. Belongs to the TVP18 family. (168 aa)
	Kpol_1068p1	Ku domain-containing protein. (514 aa)
	Kpol_340p7	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (650 aa)
	MPH1	ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1012 aa)
	Kpol_309p8	Uncharacterized protein. (233 aa)
	SLX1	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (319 aa)
	Kpol_206p4	TP6A_N domain-containing protein. (374 aa)
	Kpol_197p1	Uncharacterized protein. (1023 aa)
	Kpol_301p4	Uncharacterized protein. (195 aa)
	Kpol_167p3	Uncharacterized protein. (274 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kpol_1007p11	Kpol_1007p13	A7TRT3	A7TRT5	ERCC4 domain-containing protein.	RMI1_N domain-containing protein.	0.860
Kpol_1007p11	Kpol_1018p126	A7TRT3	A7TDW9	ERCC4 domain-containing protein.	AA_TRNA_LIGASE_II domain-containing protein.	0.962
Kpol_1007p11	Kpol_1018p159	A7TRT3	A7TE00	ERCC4 domain-containing protein.	Ku domain-containing protein.	0.568
Kpol_1007p11	Kpol_1018p31	A7TRT3	A7TDN2	ERCC4 domain-containing protein.	Uncharacterized protein.	0.536
Kpol_1007p11	Kpol_1018p90	A7TRT3	A7TDT7	ERCC4 domain-containing protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.851
Kpol_1007p11	Kpol_1023p71	A7TRT3	A7TFU4	ERCC4 domain-containing protein.	Uncharacterized protein.	0.864
Kpol_1007p11	Kpol_1025p37	A7TRT3	A7TKW2	ERCC4 domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.974
Kpol_1007p11	Kpol_1032p38	A7TRT3	A7TGZ2	ERCC4 domain-containing protein.	RECA_2 domain-containing protein.	0.728
Kpol_1007p11	Kpol_1032p7	A7TRT3	A7TGW3	ERCC4 domain-containing protein.	DNA ligase.	0.622
Kpol_1007p11	Kpol_1036p43	A7TRT3	A7TEJ3	ERCC4 domain-containing protein.	RECA_2 domain-containing protein.	0.685
Kpol_1007p11	Kpol_1045p22	A7TRT3	A7TI29	ERCC4 domain-containing protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.659
Kpol_1007p11	Kpol_1050p80	A7TRT3	A7TEX4	ERCC4 domain-containing protein.	Uncharacterized protein.	0.684
Kpol_1007p11	Kpol_1052p39	A7TRT3	A7TM49	ERCC4 domain-containing protein.	Uncharacterized protein; Belongs to the RecA family.	0.528
Kpol_1007p11	Kpol_1053p32	A7TRT3	A7TN77	ERCC4 domain-containing protein.	Uncharacterized protein.	0.633
Kpol_1007p11	Kpol_1055p88	A7TRT3	A7TGG1	ERCC4 domain-containing protein.	Uncharacterized protein.	0.623
Kpol_1007p11	Kpol_1068p1	A7TRT3	A7TSQ6	ERCC4 domain-containing protein.	Ku domain-containing protein.	0.560
Kpol_1007p11	Kpol_1071p14	A7TRT3	A7TRK9	ERCC4 domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.547
Kpol_1007p11	Kpol_167p3	A7TRT3	A7TTS8	ERCC4 domain-containing protein.	Uncharacterized protein.	0.879
Kpol_1007p11	Kpol_197p1	A7TRT3	A7TTJ2	ERCC4 domain-containing protein.	Uncharacterized protein.	0.528
Kpol_1007p11	Kpol_2000p34	A7TRT3	A7TF44	ERCC4 domain-containing protein.	Zinc-hook domain-containing protein.	0.514