(86 nodes) Metabolism of carbohydrates, and Alcohol dehydrogenase, zinc-type, conserved site network (Vanderwaltozyma polyspora)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Kpol_1018p12	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (967 aa)
	Kpol_1018p161	Uncharacterized protein; Belongs to the phosphohexose mutase family. (569 aa)
	Kpol_1002p6	UTP--glucose-1-phosphate uridylyltransferase. (502 aa)
	Kpol_1002p112	AcetylCoA_hyd_C domain-containing protein. (526 aa)
	Kpol_1036p19	PKS_ER domain-containing protein. (353 aa)
	Kpol_1036p26	NAD(P)-bd_dom domain-containing protein. (702 aa)
	Kpol_1036p27	Uncharacterized protein. (541 aa)
	Kpol_1050p17	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (415 aa)
	Kpol_1050p72	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (989 aa)
	Kpol_1050p78	6-phosphogluconolactonase-like protein; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. (254 aa)
	Kpol_1050p87	Uncharacterized protein. (437 aa)
	Kpol_2000p103	Phosphotransferase. (497 aa)
	Kpol_2002p32	Phosphotransferase. (501 aa)
	Kpol_1028p37	6-phosphogluconolactonase-like protein; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. (309 aa)
	Kpol_1055p62	Pribosyltran_N domain-containing protein. (426 aa)
	Kpol_2001p19	6PF2K domain-containing protein. (451 aa)
	RBK1	Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (334 aa)
	Kpol_1013p31	Uncharacterized protein. (1565 aa)
	Kpol_1039p1	6PF2K domain-containing protein. (394 aa)
	Kpol_1039p31	6PF2K domain-containing protein. (751 aa)
	Kpol_1039p57	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (682 aa)
	Kpol_543p69	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa)
	Kpol_1031p68	Gluconokinase; Belongs to the gluconokinase GntK/GntV family. (186 aa)
	Kpol_1045p40	Pribosyltran_N domain-containing protein. (339 aa)
	Kpol_1045p45	Pribosyltran_N domain-containing protein. (467 aa)
	Kpol_1045p50	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (327 aa)
	Kpol_1010p34	Uncharacterized protein. (582 aa)
	Kpol_1010p48	Uncharacterized protein. (563 aa)
	Kpol_1043p73	PINc domain-containing protein. (1260 aa)
	Kpol_1043p77	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (657 aa)
	Kpol_1033p54	Uncharacterized protein; Belongs to the phosphohexose mutase family. (570 aa)
	Kpol_1004p66	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (609 aa)
	Kpol_1061p9	SGL domain-containing protein. (335 aa)
	Kpol_534p11	Uncharacterized protein. (144 aa)
	Kpol_534p18	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (502 aa)
	Kpol_1058p11	PKS_ER domain-containing protein. (353 aa)
	Kpol_1037p45	Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (364 aa)
	Kpol_1037p46	Uncharacterized protein. (518 aa)
	Kpol_1060p13	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (957 aa)
	Kpol_1060p40	Glyceraldehyde-3-phosphate dehydrogenase. (332 aa)
	Kpol_1062p29	Aldo_ket_red domain-containing protein. (311 aa)
	Kpol_1062p39	Uncharacterized protein. (86 aa)
	Kpol_538p43	Acetyl-coenzyme A synthetase. (692 aa)
	Kpol_538p48	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (516 aa)
	Kpol_530p31	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (380 aa)
	Kpol_530p51	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (332 aa)
	RKI1	Ribose-5-phosphate isomerase. (259 aa)
	Kpol_1024p40	Glucose-6-phosphate isomerase; Belongs to the GPI family. (555 aa)
	Kpol_526p18	PKS_ER domain-containing protein. (361 aa)
	Kpol_1003p24	6PF2K domain-containing protein. (760 aa)
	Kpol_529p30	PKS_ER domain-containing protein. (360 aa)
	Kpol_520p31	Uncharacterized protein. (582 aa)
	Kpol_1064p4	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (358 aa)
	Kpol_1066p25	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (297 aa)
	Kpol_1059p5	GFO_IDH_MocA domain-containing protein. (429 aa)
	Kpol_1014p34	Uncharacterized protein. (350 aa)
	Kpol_1070p2	Uncharacterized protein; Belongs to the FGGY kinase family. (662 aa)
	Kpol_1001p30	Pribosyltran_N domain-containing protein. (433 aa)
	Kpol_1067p2	6PGD domain-containing protein. (286 aa)
	Kpol_499p9	6PF2K domain-containing protein. (502 aa)
	Kpol_1009p28	Uncharacterized protein. (250 aa)
	Kpol_507p3	Phosphotransferase. (486 aa)
	Kpol_1057p24	PKS_ER domain-containing protein. (360 aa)
	Kpol_489p3	Uncharacterized protein; Belongs to the glycosyl hydrolase 32 family. (602 aa)
	Kpol_1006p8	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (680 aa)
	Kpol_483p3	FBPase domain-containing protein; Belongs to the FBPase class 1 family. (346 aa)
	Kpol_472p17	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (336 aa)
	Kpol_1015p12	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (509 aa)
	Kpol_448p4	Uncharacterized protein. (267 aa)
	Kpol_413p15	Uncharacterized protein. (230 aa)
	Kpol_1046p9	TPP_enzyme_N domain-containing protein. (185 aa)
	Kpol_1071p12	Triosephosphate isomerase. (248 aa)
	Kpol_431p8	PKS_ER domain-containing protein. (380 aa)
	Kpol_367p8	Pyruvate kinase; Belongs to the pyruvate kinase family. (501 aa)
	Kpol_376p17	Nudix hydrolase domain-containing protein. (230 aa)
	Kpol_388p1	Uncharacterized protein. (602 aa)
	Kpol_380p1	Pribosyltran_N domain-containing protein. (320 aa)
	Kpol_312p8	Mannose-6-phosphate isomerase. (430 aa)
	Kpol_297p11	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (525 aa)
	Kpol_1068p8	Uncharacterized protein. (632 aa)
	Kpol_325p5	Glucosamine_iso domain-containing protein. (344 aa)
	Kpol_278p3	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (906 aa)
	Kpol_278p5	Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
	Kpol_257p4	PKS_ER domain-containing protein. (360 aa)
	Kpol_260p5	Enolase_C domain-containing protein. (285 aa)
	Kpol_234p2	Uncharacterized protein; Belongs to the glycosyl hydrolase 32 family. (650 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kpol_1001p30	Kpol_1006p8	A7TNR7	A7TQ44	Pribosyltran_N domain-containing protein.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.934
Kpol_1001p30	Kpol_1018p161	A7TNR7	A7TE01	Pribosyltran_N domain-containing protein.	Uncharacterized protein; Belongs to the phosphohexose mutase family.	0.904
Kpol_1001p30	Kpol_1024p40	A7TNR7	A7TLK0	Pribosyltran_N domain-containing protein.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.411
Kpol_1001p30	Kpol_1033p54	A7TNR7	A7TJ49	Pribosyltran_N domain-containing protein.	Uncharacterized protein; Belongs to the phosphohexose mutase family.	0.904
Kpol_1001p30	Kpol_1039p57	A7TNR7	A7THI2	Pribosyltran_N domain-containing protein.	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.	0.934
Kpol_1001p30	Kpol_1045p40	A7TNR7	A7TI47	Pribosyltran_N domain-containing protein.	Pribosyltran_N domain-containing protein.	0.809
Kpol_1001p30	Kpol_1045p45	A7TNR7	A7TI51	Pribosyltran_N domain-containing protein.	Pribosyltran_N domain-containing protein.	0.807
Kpol_1001p30	Kpol_1055p62	A7TNR7	A7TGD5	Pribosyltran_N domain-containing protein.	Pribosyltran_N domain-containing protein.	0.604
Kpol_1001p30	Kpol_1068p8	A7TNR7	A7TSR3	Pribosyltran_N domain-containing protein.	Uncharacterized protein.	0.922
Kpol_1001p30	Kpol_367p8	A7TNR7	A7TRQ9	Pribosyltran_N domain-containing protein.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.442
Kpol_1001p30	Kpol_376p17	A7TNR7	A7TRW7	Pribosyltran_N domain-containing protein.	Nudix hydrolase domain-containing protein.	0.903
Kpol_1001p30	Kpol_380p1	A7TNR7	A7TS61	Pribosyltran_N domain-containing protein.	Pribosyltran_N domain-containing protein.	0.808
Kpol_1001p30	RBK1	A7TNR7	A7TGT5	Pribosyltran_N domain-containing protein.	Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.	0.922
Kpol_1001p30	RKI1	A7TNR7	A7TLF7	Pribosyltran_N domain-containing protein.	Ribose-5-phosphate isomerase.	0.927
Kpol_1002p112	Kpol_1024p40	A7TEE1	A7TLK0	AcetylCoA_hyd_C domain-containing protein.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.473
Kpol_1002p112	Kpol_1050p17	A7TEE1	A7TER4	AcetylCoA_hyd_C domain-containing protein.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.545
Kpol_1002p112	Kpol_297p11	A7TEE1	A7TSL5	AcetylCoA_hyd_C domain-containing protein.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.926
Kpol_1002p112	Kpol_534p18	A7TEE1	A7TJJ6	AcetylCoA_hyd_C domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.929
Kpol_1002p112	Kpol_538p43	A7TEE1	A7TKF6	AcetylCoA_hyd_C domain-containing protein.	Acetyl-coenzyme A synthetase.	0.958
Kpol_1002p112	Kpol_538p48	A7TEE1	A7TKG1	AcetylCoA_hyd_C domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.929