(26 nodes) Mixed, incl. CD28 dependent PI3K/Akt signaling, and DAG and IP3 signaling network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_1018p54	Protein kinase domain-containing protein. (834 aa)
	Kpol_1018p162	Non-specific serine/threonine protein kinase. (678 aa)
	Kpol_2002p75	Uncharacterized protein; Belongs to the protein kinase superfamily. (423 aa)
	Kpol_1032p13	Uncharacterized protein. (877 aa)
	Kpol_1013p21	Uncharacterized protein. (494 aa)
	Kpol_1013p63	Uncharacterized protein. (485 aa)
	Kpol_1054p2	Protein kinase domain-containing protein. (1096 aa)
	Kpol_1054p51	Uncharacterized protein. (462 aa)
	Kpol_1033p50	Uncharacterized protein; Belongs to the protein kinase superfamily. (384 aa)
	Kpol_534p51	Uncharacterized protein. (1963 aa)
	Kpol_1037p52	Non-specific serine/threonine protein kinase. (512 aa)
	Kpol_1056p8	HTH APSES-type domain-containing protein. (523 aa)
	Kpol_520p17	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1164 aa)
	Kpol_1066p20	Uncharacterized protein. (525 aa)
	Kpol_1030p33	Uncharacterized protein. (1379 aa)
	Kpol_1053p45	Uncharacterized protein. (1211 aa)
	Kpol_505p1	Uncharacterized protein. (299 aa)
	Kpol_1070p32	cAMP-dependent protein kinase regulatory subunit. (425 aa)
	Kpol_1040p20	Protein kinase domain-containing protein. (1297 aa)
	Kpol_1073p8	ANK_REP_REGION domain-containing protein. (428 aa)
	Kpol_1000p14	Non-specific serine/threonine protein kinase. (665 aa)
	Kpol_487p7	WD_REPEATS_REGION domain-containing protein. (303 aa)
	Kpol_460p25	HTH APSES-type domain-containing protein. (207 aa)
	Kpol_1029p8	Uncharacterized protein. (305 aa)
	Kpol_265p1	Non-specific serine/threonine protein kinase. (757 aa)
	Kpol_185p3	Uncharacterized protein. (647 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kpol_1000p14	Kpol_1013p21	A7TPV4	A7TH69	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.565
Kpol_1000p14	Kpol_1018p54	A7TPV4	A7TDQ2	Non-specific serine/threonine protein kinase.	Protein kinase domain-containing protein.	0.679
Kpol_1000p14	Kpol_1029p8	A7TPV4	A7TR67	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.594
Kpol_1000p14	Kpol_1030p33	A7TPV4	A7TMV1	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.685
Kpol_1000p14	Kpol_1053p45	A7TPV4	A7TN89	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.648
Kpol_1000p14	Kpol_1054p2	A7TPV4	A7TI91	Non-specific serine/threonine protein kinase.	Protein kinase domain-containing protein.	0.780
Kpol_1000p14	Kpol_1054p51	A7TPV4	A7TID8	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.801
Kpol_1000p14	Kpol_1070p32	A7TPV4	A7TNN2	Non-specific serine/threonine protein kinase.	cAMP-dependent protein kinase regulatory subunit.	0.695
Kpol_1000p14	Kpol_185p3	A7TPV4	A7TTK9	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.565
Kpol_1000p14	Kpol_265p1	A7TPV4	A7TT78	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.904
Kpol_1000p14	Kpol_487p7	A7TPV4	A7TQ82	Non-specific serine/threonine protein kinase.	WD_REPEATS_REGION domain-containing protein.	0.951
Kpol_1000p14	Kpol_505p1	A7TPV4	A7TN93	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.594
Kpol_1013p21	Kpol_1000p14	A7TH69	A7TPV4	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.565
Kpol_1013p21	Kpol_1029p8	A7TH69	A7TR67	Uncharacterized protein.	Uncharacterized protein.	0.498
Kpol_1013p21	Kpol_1033p50	A7TH69	A7TJ45	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.937
Kpol_1013p21	Kpol_185p3	A7TH69	A7TTK9	Uncharacterized protein.	Uncharacterized protein.	0.900
Kpol_1013p21	Kpol_2002p75	A7TH69	A7TFJ0	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.932
Kpol_1013p21	Kpol_265p1	A7TH69	A7TT78	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.565
Kpol_1013p21	Kpol_505p1	A7TH69	A7TN93	Uncharacterized protein.	Uncharacterized protein.	0.498
Kpol_1013p63	Kpol_1029p8	A7THA8	A7TR67	Uncharacterized protein.	Uncharacterized protein.	0.518