(26 nodes) Telomere maintenance via recombination network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_301p4	Uncharacterized protein. (195 aa)
	Kpol_1018p31	Uncharacterized protein. (1332 aa)
	Kpol_1018p90	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (385 aa)
	Kpol_1036p43	RECA_2 domain-containing protein. (460 aa)
	Kpol_2000p34	Zinc-hook domain-containing protein. (1305 aa)
	Kpol_2002p67	Uncharacterized protein. (116 aa)
	Kpol_1023p66	Uncharacterized protein; Belongs to the CGI121/TPRKB family. (153 aa)
	Kpol_1023p71	Uncharacterized protein. (601 aa)
	Kpol_1055p70	E3 ubiquitin protein ligase. (668 aa)
	Kpol_2001p43	Uncharacterized protein. (130 aa)
	Kpol_543p24	Uncharacterized protein. (455 aa)
	KAE1	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (386 aa)
	Kpol_1045p57	HMG box domain-containing protein. (291 aa)
	Kpol_541p31	Uncharacterized protein. (941 aa)
	Kpol_1058p26	Uncharacterized protein. (248 aa)
	Kpol_1060p23	Uncharacterized protein. (1280 aa)
	Kpol_1025p37	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (618 aa)
	Kpol_526p12	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2392 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (632 aa)
	Kpol_1030p34	Uncharacterized protein. (129 aa)
	PIF1-2	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (958 aa)
	Kpol_1067p11	Protein kinase domain-containing protein. (270 aa)
	Kpol_1009p15	Uncharacterized protein. (124 aa)
	Kpol_483p12	DNA repair protein RAD59; Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA. (203 aa)
	Kpol_167p3	Uncharacterized protein. (274 aa)
	Kpol_461p8	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KAE1	Kpol_1023p66	A7THX2	A7TFT9	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Uncharacterized protein; Belongs to the CGI121/TPRKB family.	0.997
KAE1	Kpol_1067p11	A7THX2	A7TNV6	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Protein kinase domain-containing protein.	0.999
KAE1	Kpol_2001p43	A7THX2	A7TGS5	tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]	Uncharacterized protein.	0.981
Kpol_1009p15	Kpol_1030p34	A7TPE1	A7TMV2	Uncharacterized protein.	Uncharacterized protein.	0.742
Kpol_1009p15	Kpol_1045p57	A7TPE1	A7TI63	Uncharacterized protein.	HMG box domain-containing protein.	0.590
Kpol_1009p15	Kpol_1058p26	A7TPE1	A7TJR0	Uncharacterized protein.	Uncharacterized protein.	0.782
Kpol_1018p31	Kpol_1018p90	A7TDN2	A7TDT7	Uncharacterized protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.843
Kpol_1018p31	Kpol_1023p71	A7TDN2	A7TFU4	Uncharacterized protein.	Uncharacterized protein.	0.816
Kpol_1018p31	Kpol_1025p37	A7TDN2	A7TKW2	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.782
Kpol_1018p31	Kpol_1036p43	A7TDN2	A7TEJ3	Uncharacterized protein.	RECA_2 domain-containing protein.	0.807
Kpol_1018p31	Kpol_167p3	A7TDN2	A7TTS8	Uncharacterized protein.	Uncharacterized protein.	0.539
Kpol_1018p31	Kpol_2000p34	A7TDN2	A7TF44	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.499
Kpol_1018p31	Kpol_483p12	A7TDN2	A7TQ64	Uncharacterized protein.	DNA repair protein RAD59; Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA.	0.514
Kpol_1018p31	Kpol_526p12	A7TDN2	A7TLR7	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.796
Kpol_1018p31	Kpol_541p31	A7TDN2	A7TIX6	Uncharacterized protein.	Uncharacterized protein.	0.603
Kpol_1018p31	Kpol_543p24	A7TDN2	A7THM9	Uncharacterized protein.	Uncharacterized protein.	0.523
Kpol_1018p31	PIF1	A7TDN2	A7TMC2	Uncharacterized protein.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]	0.431
Kpol_1018p31	PIF1-2	A7TDN2	A7TNQ0	Uncharacterized protein.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]	0.431
Kpol_1018p90	Kpol_1018p31	A7TDT7	A7TDN2	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.843
Kpol_1018p90	Kpol_1023p71	A7TDT7	A7TFU4	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	Uncharacterized protein.	0.995