(71 nodes) Double-strand break repair via homologous recombination network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_1039p64	WLM domain-containing protein. (245 aa)
	Kpol_1032p38	RECA_2 domain-containing protein. (422 aa)
	Kpol_1032p37	Serine/threonine-protein phosphatase. (307 aa)
	Kpol_1048p73	Uncharacterized protein. (1549 aa)
	Kpol_1055p88	Uncharacterized protein. (182 aa)
	Kpol_1018p31	Uncharacterized protein. (1332 aa)
	Kpol_1018p2	Structural maintenance of chromosomes protein. (1211 aa)
	Kpol_1030p7	Sister chromatid cohesion protein. (1490 aa)
	Kpol_151p2	Uncharacterized protein. (397 aa)
	Kpol_167p3	Uncharacterized protein. (274 aa)
	Kpol_272p1	Uncharacterized protein. (1555 aa)
	Kpol_293p3	Uncharacterized protein. (300 aa)
	Kpol_293p1	Helicase C-terminal domain-containing protein. (119 aa)
	Kpol_278p4	DNA helicase; Belongs to the MCM family. (1011 aa)
	Kpol_274p5	DNA helicase; Belongs to the MCM family. (934 aa)
	Kpol_381p5	Sir1 domain-containing protein. (750 aa)
	Kpol_381p4	Uncharacterized protein. (454 aa)
	Kpol_462p7	Uncharacterized protein. (555 aa)
	Kpol_462p5	Uncharacterized protein. (154 aa)
	Kpol_1012p2	Uncharacterized protein. (589 aa)
	Kpol_1007p13	RMI1_N domain-containing protein. (248 aa)
	Kpol_1007p8	DNA helicase; Belongs to the MCM family. (892 aa)
	Kpol_431p4	AAA domain-containing protein. (757 aa)
	Kpol_413p14	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (693 aa)
	Kpol_440p9	ERCC4 domain-containing protein. (620 aa)
	Kpol_458p4	Uncharacterized protein. (286 aa)
	Kpol_461p8	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
	Kpol_1038p8	Sld5 domain-containing protein. (206 aa)
	Kpol_1038p1	Helicase C-terminal domain-containing protein. (562 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (840 aa)
	Kpol_1027p11	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (216 aa)
	Kpol_467p19	Uncharacterized protein. (387 aa)
	Kpol_479p14	Uncharacterized protein. (223 aa)
	Kpol_483p10	AAA_23 domain-containing protein. (1118 aa)
	Kpol_1009p1	DNA helicase; Belongs to the MCM family. (760 aa)
	Kpol_1044p13	AAA_23 domain-containing protein. (1103 aa)
	Kpol_495p15	Deacetylase sirtuin-type domain-containing protein. (440 aa)
	Kpol_495p5	Uncharacterized protein. (817 aa)
	Kpol_1067p34	Uncharacterized protein. (360 aa)
	Kpol_1016p19	Uncharacterized protein. (759 aa)
	PIF1-2	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (958 aa)
	Kpol_1053p28	Uncharacterized protein. (315 aa)
	Kpol_1053p4	Sld5 domain-containing protein. (209 aa)
	Kpol_1030p1	Deacetylase sirtuin-type domain-containing protein. (374 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (632 aa)
	Kpol_1052p39	Uncharacterized protein; Belongs to the RecA family. (334 aa)
	Kpol_1056p27	SP-RING-type domain-containing protein. (275 aa)
	Kpol_1025p37	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (618 aa)
	Kpol_1060p23	Uncharacterized protein. (1280 aa)
	Kpol_534p58	Histone acetyltransferase. (430 aa)
	Kpol_1061p28	Uncharacterized protein. (85 aa)
	Kpol_1004p48	ECM11 domain-containing protein. (312 aa)
	Kpol_1004p41	Uncharacterized protein. (267 aa)
	Kpol_1033p22	Uncharacterized protein. (660 aa)
	Kpol_541p42	Uncharacterized protein. (342 aa)
	Kpol_1043p71	Zf-primase domain-containing protein. (585 aa)
	Kpol_1010p68	Protein kinase domain-containing protein. (500 aa)
	Kpol_1045p54	Uncharacterized protein. (603 aa)
	Kpol_1055p70	E3 ubiquitin protein ligase. (668 aa)
	Kpol_1023p83	Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (452 aa)
	Kpol_1023p71	Uncharacterized protein. (601 aa)
	Kpol_2002p67	Uncharacterized protein. (116 aa)
	Kpol_2000p112	Uncharacterized protein. (988 aa)
	Kpol_2000p111	Uncharacterized protein. (302 aa)
	Kpol_1050p99	Mcl1_mid domain-containing protein. (901 aa)
	Kpol_1036p43	RECA_2 domain-containing protein. (460 aa)
	Kpol_1036p22	WD_REPEATS_REGION domain-containing protein. (1033 aa)
	Kpol_1018p159	Ku domain-containing protein. (629 aa)
	Kpol_1018p90	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (385 aa)
	Kpol_1018p62	Uncharacterized protein. (591 aa)
	Kpol_1018p52	Uncharacterized protein. (182 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kpol_1007p13	Kpol_1016p19	A7TRT5	A7TNT4	RMI1_N domain-containing protein.	Uncharacterized protein.	0.680
Kpol_1007p13	Kpol_1018p31	A7TRT5	A7TDN2	RMI1_N domain-containing protein.	Uncharacterized protein.	0.579
Kpol_1007p13	Kpol_1018p90	A7TRT5	A7TDT7	RMI1_N domain-containing protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.781
Kpol_1007p13	Kpol_1023p71	A7TRT5	A7TFU4	RMI1_N domain-containing protein.	Uncharacterized protein.	0.710
Kpol_1007p13	Kpol_1025p37	A7TRT5	A7TKW2	RMI1_N domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.888
Kpol_1007p13	Kpol_1032p38	A7TRT5	A7TGZ2	RMI1_N domain-containing protein.	RECA_2 domain-containing protein.	0.743
Kpol_1007p13	Kpol_1036p43	A7TRT5	A7TEJ3	RMI1_N domain-containing protein.	RECA_2 domain-containing protein.	0.810
Kpol_1007p13	Kpol_1038p1	A7TRT5	A7TQZ4	RMI1_N domain-containing protein.	Helicase C-terminal domain-containing protein.	0.579
Kpol_1007p13	Kpol_1044p13	A7TRT5	A7TP44	RMI1_N domain-containing protein.	AAA_23 domain-containing protein.	0.578
Kpol_1007p13	Kpol_1052p39	A7TRT5	A7TM49	RMI1_N domain-containing protein.	Uncharacterized protein; Belongs to the RecA family.	0.631
Kpol_1007p13	Kpol_1055p88	A7TRT5	A7TGG1	RMI1_N domain-containing protein.	Uncharacterized protein.	0.596
Kpol_1007p13	Kpol_1056p27	A7TRT5	A7TLN4	RMI1_N domain-containing protein.	SP-RING-type domain-containing protein.	0.432
Kpol_1007p13	Kpol_1060p23	A7TRT5	A7TK21	RMI1_N domain-containing protein.	Uncharacterized protein.	0.579
Kpol_1007p13	Kpol_151p2	A7TRT5	A7TTV4	RMI1_N domain-containing protein.	Uncharacterized protein.	0.579
Kpol_1007p13	Kpol_167p3	A7TRT5	A7TTS8	RMI1_N domain-containing protein.	Uncharacterized protein.	0.776
Kpol_1007p13	Kpol_2000p111	A7TRT5	A7TFB8	RMI1_N domain-containing protein.	Uncharacterized protein.	0.579
Kpol_1007p13	Kpol_2000p112	A7TRT5	A7TFB9	RMI1_N domain-containing protein.	Uncharacterized protein.	0.579
Kpol_1007p13	Kpol_272p1	A7TRT5	A7TTF0	RMI1_N domain-containing protein.	Uncharacterized protein.	0.579
Kpol_1007p13	Kpol_293p1	A7TRT5	A7TTA7	RMI1_N domain-containing protein.	Helicase C-terminal domain-containing protein.	0.579
Kpol_1007p13	Kpol_293p3	A7TRT5	A7TTA8	RMI1_N domain-containing protein.	Uncharacterized protein.	0.579