(24 nodes) Negative regulation of cellular catabolic process network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_1023p6	Uncharacterized protein. (274 aa)
	Kpol_1013p79	Phospholipid scramblase; Belongs to the phospholipid scramblase family. (336 aa)
	Kpol_1039p66	mRNA stability protein; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. (128 aa)
	Kpol_1054p51	Uncharacterized protein. (462 aa)
	Kpol_1010p41	Peptidyl-prolyl cis-trans isomerase. (164 aa)
	Kpol_541p18	Uncharacterized protein. (326 aa)
	Kpol_541p40	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1521 aa)
	Kpol_534p39	Uncharacterized protein. (560 aa)
	Kpol_1037p30	Uncharacterized protein. (367 aa)
	Kpol_1024p12	Uncharacterized protein. (240 aa)
	Kpol_1064p9	TCTP domain-containing protein; Belongs to the TCTP family. (167 aa)
	Kpol_1066p24	Uncharacterized protein. (458 aa)
	Kpol_1014p32	Uncharacterized protein. (1084 aa)
	Kpol_1026p27	Uncharacterized protein. (344 aa)
	Kpol_1019p28	Uncharacterized protein. (202 aa)
	Kpol_1073p1	Uncharacterized protein. (361 aa)
	Kpol_1006p9	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1292 aa)
	Kpol_479p21	Uncharacterized protein. (214 aa)
	ATP25	ATPase synthesis protein 25, mitochondrial; Probable mitochondrial mRNA stabilization factor. Belongs to the ATP25 family. (628 aa)
	Kpol_472p12	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (103 aa)
	Kpol_448p11	N-acetyltransferase domain-containing protein. (589 aa)
	Kpol_1029p10	Chromatin modification-related protein. (365 aa)
	Kpol_1007p17	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (307 aa)
	Kpol_303p7	ANK_REP_REGION domain-containing protein. (708 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kpol_1006p9	Kpol_541p40	A7TQ45	A7TIY6	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	0.904
Kpol_1007p17	Kpol_1023p6	A7TRT9	A7TFM9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.609
Kpol_1007p17	Kpol_1037p30	A7TRT9	A7TJX2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.892
Kpol_1014p32	Kpol_1066p24	A7TNF9	A7TMP5	Uncharacterized protein.	Uncharacterized protein.	0.999
Kpol_1014p32	Kpol_472p12	A7TNF9	A7TQI0	Uncharacterized protein.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.930
Kpol_1023p6	Kpol_1007p17	A7TFM9	A7TRT9	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.609
Kpol_1026p27	Kpol_1054p51	A7TNJ6	A7TID8	Uncharacterized protein.	Uncharacterized protein.	0.986
Kpol_1026p27	Kpol_541p18	A7TNJ6	A7TIW3	Uncharacterized protein.	Uncharacterized protein.	0.999
Kpol_1037p30	Kpol_1007p17	A7TJX2	A7TRT9	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.892
Kpol_1037p30	Kpol_1054p51	A7TJX2	A7TID8	Uncharacterized protein.	Uncharacterized protein.	0.423
Kpol_1054p51	Kpol_1026p27	A7TID8	A7TNJ6	Uncharacterized protein.	Uncharacterized protein.	0.986
Kpol_1054p51	Kpol_1037p30	A7TID8	A7TJX2	Uncharacterized protein.	Uncharacterized protein.	0.423
Kpol_1054p51	Kpol_541p18	A7TID8	A7TIW3	Uncharacterized protein.	Uncharacterized protein.	0.994
Kpol_1066p24	Kpol_1014p32	A7TMP5	A7TNF9	Uncharacterized protein.	Uncharacterized protein.	0.999
Kpol_1066p24	Kpol_472p12	A7TMP5	A7TQI0	Uncharacterized protein.	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	0.911
Kpol_1073p1	Kpol_303p7	A7TPR4	A7TT04	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.708
Kpol_303p7	Kpol_1073p1	A7TT04	A7TPR4	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.708
Kpol_472p12	Kpol_1014p32	A7TQI0	A7TNF9	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	Uncharacterized protein.	0.930
Kpol_472p12	Kpol_1066p24	A7TQI0	A7TMP5	Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.	Uncharacterized protein.	0.911
Kpol_541p18	Kpol_1026p27	A7TIW3	A7TNJ6	Uncharacterized protein.	Uncharacterized protein.	0.999