(53 nodes) Regulation of mRNA catabolic process network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_526p35	RING-type domain-containing protein. (655 aa)
	Kpol_1056p31	Uncharacterized protein. (576 aa)
	Kpol_1020p21	Uncharacterized protein. (640 aa)
	Kpol_530p46	Uncharacterized protein. (587 aa)
	Kpol_530p34	NOT2_3_5 domain-containing protein. (191 aa)
	Kpol_1035p20	Uncharacterized protein. (1077 aa)
	Kpol_1035p6	Uncharacterized protein. (308 aa)
	Kpol_1062p20	YTH domain-containing protein. (365 aa)
	Kpol_1060p55	RPOL4c domain-containing protein. (221 aa)
	Kpol_1037p29	HRDC domain-containing protein. (746 aa)
	Kpol_534p39	Uncharacterized protein. (560 aa)
	Kpol_1061p41	PUM-HD domain-containing protein. (739 aa)
	Kpol_1033p30	USP domain-containing protein. (1168 aa)
	Kpol_541p44	PUM-HD domain-containing protein. (756 aa)
	Kpol_541p40	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1521 aa)
	Kpol_1043p34	Uncharacterized protein. (442 aa)
	Kpol_1010p19	Uncharacterized protein. (1066 aa)
	Kpol_1054p28	RRM domain-containing protein. (683 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation. (177 aa)
	Kpol_1039p66	mRNA stability protein; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. (128 aa)
	Kpol_1032p49	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (580 aa)
	Kpol_2001p52	RNase_PH domain-containing protein. (392 aa)
	Kpol_1018p178	Uncharacterized protein. (597 aa)
	Kpol_1036p104	Tr-type G domain-containing protein. (687 aa)
	Kpol_2002p50	RNase_PH domain-containing protein. (378 aa)
	Kpol_1028p8	Uncharacterized protein. (427 aa)
	Kpol_1028p15	Uncharacterized protein. (2019 aa)
	Kpol_1028p33	Uncharacterized protein. (912 aa)
	Kpol_1048p23	Nudix hydrolase domain-containing protein. (835 aa)
	Kpol_478p14	PUM-HD domain-containing protein. (841 aa)
	Kpol_1049p1	SAM domain-containing protein. (537 aa)
	Kpol_1073p1	Uncharacterized protein. (361 aa)
	Kpol_473p23	Uncharacterized protein. (223 aa)
	Kpol_1006p7	Uncharacterized protein. (540 aa)
	Kpol_1006p9	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1292 aa)
	Kpol_487p6	Uncharacterized protein. (376 aa)
	Kpol_1042p10	Uncharacterized protein. (364 aa)
	ATP25	ATPase synthesis protein 25, mitochondrial; Probable mitochondrial mRNA stabilization factor. Belongs to the ATP25 family. (628 aa)
	Kpol_463p3	tRNA ligase. (823 aa)
	Kpol_458p1	Uncharacterized protein. (1751 aa)
	Kpol_400p1	RRM domain-containing protein. (600 aa)
	Kpol_1076p8	Uncharacterized protein. (524 aa)
	Kpol_297p7	WD_REPEATS_REGION domain-containing protein. (318 aa)
	Kpol_1075p1a	Uncharacterized protein. (264 aa)
	Kpol_303p7	ANK_REP_REGION domain-containing protein. (708 aa)
	Kpol_186p3	Uncharacterized protein. (171 aa)
	Kpol_1040p14	Endo/exonuclease/phosphatase domain-containing protein. (784 aa)
	Kpol_1057p18	C3H1-type domain-containing protein. (440 aa)
	Kpol_1070p25	NOT2_3_5 domain-containing protein. (401 aa)
	Kpol_1070p20	Fe2OG dioxygenase domain-containing protein. (629 aa)
	Kpol_1014p33	Uncharacterized protein. (203 aa)
	Kpol_520p17	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1164 aa)
	Kpol_520p3	Uncharacterized protein. (1067 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kpol_1006p7	Kpol_1028p15	A7TQ43	A7TFY5	Uncharacterized protein.	Uncharacterized protein.	0.962
Kpol_1006p7	Kpol_1028p33	A7TQ43	A7TG03	Uncharacterized protein.	Uncharacterized protein.	0.841
Kpol_1006p7	Kpol_1028p8	A7TQ43	A7TFX9	Uncharacterized protein.	Uncharacterized protein.	0.990
Kpol_1006p7	Kpol_1040p14	A7TQ43	A7TPK9	Uncharacterized protein.	Endo/exonuclease/phosphatase domain-containing protein.	0.987
Kpol_1006p7	Kpol_1070p25	A7TQ43	A7TNM5	Uncharacterized protein.	NOT2_3_5 domain-containing protein.	0.997
Kpol_1006p7	Kpol_297p7	A7TQ43	A7TSL1	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.464
Kpol_1006p7	Kpol_458p1	A7TQ43	A7TR95	Uncharacterized protein.	Uncharacterized protein.	0.962
Kpol_1006p7	Kpol_530p34	A7TQ43	A7TL08	Uncharacterized protein.	NOT2_3_5 domain-containing protein.	0.998
Kpol_1006p9	Kpol_1014p33	A7TQ45	A7TNG0	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	Uncharacterized protein.	0.936
Kpol_1006p9	Kpol_1028p33	A7TQ45	A7TG03	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	Uncharacterized protein.	0.872
Kpol_1006p9	Kpol_1035p20	A7TQ45	A7TKI5	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	Uncharacterized protein.	0.497
Kpol_1006p9	Kpol_1037p29	A7TQ45	A7TJX1	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	HRDC domain-containing protein.	0.418
Kpol_1006p9	Kpol_1048p23	A7TQ45	A7TGI6	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	Nudix hydrolase domain-containing protein.	0.902
Kpol_1006p9	Kpol_1056p31	A7TQ45	A7TLN8	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	Uncharacterized protein.	0.715
Kpol_1006p9	Kpol_2001p52	A7TQ45	A7TGT4	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	RNase_PH domain-containing protein.	0.556
Kpol_1006p9	Kpol_2002p50	A7TQ45	A7TFG5	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	RNase_PH domain-containing protein.	0.556
Kpol_1006p9	Kpol_297p7	A7TQ45	A7TSL1	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	WD_REPEATS_REGION domain-containing protein.	0.700
Kpol_1006p9	Kpol_473p23	A7TQ45	A7TQ15	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	Uncharacterized protein.	0.724
Kpol_1006p9	Kpol_530p46	A7TQ45	A7TL20	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	Uncharacterized protein.	0.632
Kpol_1006p9	Kpol_541p40	A7TQ45	A7TIY6	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.	0.904