(53 nodes) Supramolecular fiber organization network (Vanderwaltozyma polyspora)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Kpol_543p20	Uncharacterized protein. (633 aa)
	Kpol_1013p7	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (620 aa)
	Kpol_1032p6	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1004 aa)
	Kpol_2001p70	ENTH domain-containing protein. (533 aa)
	Kpol_1048p14	Spindle pole body component. (837 aa)
	Kpol_1028p49	ENTH domain-containing protein. (805 aa)
	Kpol_2002p41	CAP-Gly domain-containing protein. (439 aa)
	Kpol_1056p16	Uncharacterized protein; Belongs to the actin family. (460 aa)
	Kpol_1003p45	Uncharacterized protein. (280 aa)
	Kpol_1064p15	Uncharacterized protein. (646 aa)
	Kpol_1066p42	Rab-GAP TBC domain-containing protein. (656 aa)
	Kpol_505p30	Adenylyl cyclase-associated protein; Belongs to the CAP family. (530 aa)
	Kpol_1014p9	BAR domain-containing protein. (265 aa)
	Kpol_1001p23	Coronin; Belongs to the WD repeat coronin family. (610 aa)
	Kpol_1049p5	TIR domain-containing protein. (783 aa)
	Kpol_1049p10	Calponin-homology (CH) domain-containing protein. (206 aa)
	Kpol_1049p22	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (151 aa)
	Kpol_1073p3	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (171 aa)
	Kpol_1008p25	SH3 domain-containing protein. (449 aa)
	Kpol_473p4	Uncharacterized protein. (528 aa)
	Kpol_479p25	Uncharacterized protein; Belongs to the actin family. (391 aa)
	Kpol_467p21	Uncharacterized protein. (604 aa)
	Kpol_472p6	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (176 aa)
	Kpol_448p13	Protein kinase domain-containing protein. (670 aa)
	Kpol_423p8	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (806 aa)
	Kpol_401p2	Uncharacterized protein. (327 aa)
	Kpol_411p15	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
	Kpol_344p8	ENTH domain-containing protein. (384 aa)
	Kpol_325p7	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (331 aa)
	Kpol_1020p18	Rab-GAP TBC domain-containing protein. (611 aa)
	Kpol_1020p46	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	Kpol_1072p56	Uncharacterized protein. (637 aa)
	Kpol_1035p48	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	Kpol_538p47	Uncharacterized protein. (948 aa)
	Kpol_538p25	SH3 domain-containing protein. (707 aa)
	Kpol_538p6	Uncharacterized protein. (328 aa)
	Kpol_1062p48	AIP3 domain-containing protein. (814 aa)
	Kpol_1062p1	Spindle pole body component. (806 aa)
	Kpol_1060p48	SH3 domain-containing protein. (1047 aa)
	Kpol_1060p30	Calponin-homology (CH) domain-containing protein. (1513 aa)
	Kpol_1010p46	Uncharacterized protein. (854 aa)
	Kpol_1045p73	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (962 aa)
	Kpol_1045p27	Uncharacterized protein. (880 aa)
	Kpol_1045p5	Uncharacterized protein. (77 aa)
	Kpol_1031p32	Protein kinase domain-containing protein. (664 aa)
	Kpol_543p51	Uncharacterized protein. (640 aa)
	Kpol_2000p5	Uncharacterized protein. (199 aa)
	Kpol_1050p14	BAR domain-containing protein. (168 aa)
	Kpol_1002p120	Uncharacterized protein. (161 aa)
	END3	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (368 aa)
	Kpol_1002p94	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family. (379 aa)
	Kpol_1018p107	Uncharacterized protein. (1127 aa)
	Kpol_2002p37	Uncharacterized protein. (323 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
END3	Kpol_1018p107	A7TEE6	A7TDV4	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.401
END3	Kpol_1028p49	A7TEE6	A7TG17	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	ENTH domain-containing protein.	0.739
END3	Kpol_1045p27	A7TEE6	A7TI34	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.401
END3	Kpol_1064p15	A7TEE6	A7TME0	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.537
END3	Kpol_1072p56	A7TEE6	A7TKS4	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.521
END3	Kpol_2001p70	A7TEE6	A7TGV0	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	ENTH domain-containing protein.	0.582
END3	Kpol_344p8	A7TEE6	A7TSS4	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	ENTH domain-containing protein.	0.432
END3	Kpol_543p20	A7TEE6	A7THM5	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.750
END3	Kpol_543p51	A7TEE6	A7THQ5	Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).	Uncharacterized protein.	0.450
Kpol_1001p23	Kpol_1028p49	A7TNR0	A7TG17	Coronin; Belongs to the WD repeat coronin family.	ENTH domain-containing protein.	0.541
Kpol_1001p23	Kpol_1049p22	A7TNR0	A7TPR2	Coronin; Belongs to the WD repeat coronin family.	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family.	0.711
Kpol_1001p23	Kpol_1056p16	A7TNR0	A7TLM3	Coronin; Belongs to the WD repeat coronin family.	Uncharacterized protein; Belongs to the actin family.	0.403
Kpol_1001p23	Kpol_1062p48	A7TNR0	A7TKA3	Coronin; Belongs to the WD repeat coronin family.	AIP3 domain-containing protein.	0.464
Kpol_1001p23	Kpol_467p21	A7TNR0	A7TQG5	Coronin; Belongs to the WD repeat coronin family.	Uncharacterized protein.	0.525
Kpol_1001p23	Kpol_472p6	A7TNR0	A7TQH4	Coronin; Belongs to the WD repeat coronin family.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.459
Kpol_1001p23	Kpol_479p25	A7TNR0	A7TQD8	Coronin; Belongs to the WD repeat coronin family.	Uncharacterized protein; Belongs to the actin family.	0.773
Kpol_1001p23	Kpol_538p6	A7TNR0	A7TKB9	Coronin; Belongs to the WD repeat coronin family.	Uncharacterized protein.	0.552
Kpol_1001p23	Kpol_543p20	A7TNR0	A7THM5	Coronin; Belongs to the WD repeat coronin family.	Uncharacterized protein.	0.662
Kpol_1001p23	Kpol_543p51	A7TNR0	A7THQ5	Coronin; Belongs to the WD repeat coronin family.	Uncharacterized protein.	0.633
Kpol_1002p120	Kpol_1049p10	A7TEE8	A7TPQ0	Uncharacterized protein.	Calponin-homology (CH) domain-containing protein.	0.644