(74 nodes) AAA+ ATPase domain network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_513p23	Uncharacterized protein. (708 aa)
	Kpol_1030p2	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (461 aa)
	Kpol_1059p29	Replication factor C subunit 1. (858 aa)
	Kpol_1014p31	Uncharacterized protein. (1044 aa)
	Kpol_1014p42	Uncharacterized protein. (570 aa)
	Kpol_1070p24	AAA domain-containing protein; Belongs to the AAA ATPase family. (881 aa)
	Kpol_1001p11	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (920 aa)
	PIF1-2	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (958 aa)
	Kpol_1044p15	Uncharacterized protein. (839 aa)
	Kpol_1057p6	Uncharacterized protein. (679 aa)
	Kpol_478p4	Uncharacterized protein; Belongs to the ClpA/ClpB family. (913 aa)
	Kpol_1008p8	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (504 aa)
	Kpol_489p5	Uncharacterized protein. (1048 aa)
	Kpol_483p20	Uncharacterized protein. (783 aa)
	Kpol_487p13	Uncharacterized protein. (1044 aa)
	Kpol_467p23	AAA domain-containing protein. (859 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (840 aa)
	Kpol_401p3	AAA domain-containing protein. (786 aa)
	Kpol_431p4	AAA domain-containing protein. (757 aa)
	Kpol_1007p5	Lon proteolytic domain-containing protein; Belongs to the peptidase S16 family. (672 aa)
	Kpol_385p7	AAA domain-containing protein; Belongs to the AAA ATPase family. (362 aa)
	Kpol_1012p10	ABC transporter domain-containing protein. (242 aa)
	Kpol_364p12	ABC transporter domain-containing protein. (473 aa)
	Kpol_311p3	Uncharacterized protein. (1657 aa)
	Kpol_264p5	AAA domain-containing protein. (356 aa)
	Kpol_337p1	AAA domain-containing protein. (999 aa)
	Kpol_223p4	Uncharacterized protein. (496 aa)
	Kpol_175p1	Uncharacterized protein. (1377 aa)
	Kpol_1018p70	Uncharacterized protein; Belongs to the ClpA/ClpB family. (797 aa)
	Kpol_1018p90	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (385 aa)
	Kpol_1018p177	AAA domain-containing protein. (350 aa)
	Kpol_1018p185	Uncharacterized protein. (1276 aa)
	Kpol_1002p29	Uncharacterized protein. (1182 aa)
	Kpol_1002p105	Uncharacterized protein. (547 aa)
	Kpol_1036p28	Uncharacterized protein; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1486 aa)
	Kpol_1036p43	RECA_2 domain-containing protein. (460 aa)
	Kpol_1050p16	ABC transporter domain-containing protein. (1047 aa)
	Kpol_1050p26	Uncharacterized protein. (610 aa)
	Kpol_2000p15	Uncharacterized protein; Belongs to the AAA ATPase family. (823 aa)
	Kpol_2000p79	Uncharacterized protein. (707 aa)
	Kpol_2002p52	Cell division control protein; Belongs to the CDC6/cdc18 family. (497 aa)
	Kpol_1028p75	Uncharacterized protein. (1982 aa)
	Kpol_1055p54	ABC transporter domain-containing protein. (904 aa)
	Kpol_1048p53	AAA domain-containing protein; Belongs to the AAA ATPase family. (552 aa)
	Kpol_1048p61	AAA domain-containing protein. (792 aa)
	Kpol_1048p72	Uncharacterized protein. (1044 aa)
	Kpol_1032p48	Uncharacterized protein. (607 aa)
	Kpol_1032p87	AAA domain-containing protein; Belongs to the AAA ATPase family. (464 aa)
	Kpol_1013p42	Uncharacterized protein; Belongs to the AAA ATPase family. (430 aa)
	Kpol_1013p57	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (505 aa)
	Kpol_543p17	AAA domain-containing protein; Belongs to the AAA ATPase family. (428 aa)
	Kpol_1045p11	AAA domain-containing protein; Belongs to the AAA ATPase family. (695 aa)
	Kpol_1045p83	Uncharacterized protein. (748 aa)
	Kpol_1010p74	AAA domain-containing protein; Belongs to the AAA ATPase family. (437 aa)
	Kpol_1043p43	Uncharacterized protein. (752 aa)
	Kpol_1033p28	Uncharacterized protein. (1531 aa)
	Kpol_1037p47	Uncharacterized protein; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1507 aa)
	Kpol_1060p7	Uncharacterized protein. (1460 aa)
	Kpol_1060p32	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (474 aa)
	Kpol_1062p18	Uncharacterized protein; Belongs to the AAA ATPase family. (446 aa)
	Kpol_1062p33	AAA domain-containing protein; Belongs to the AAA ATPase family. (434 aa)
	Kpol_538p10	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (577 aa)
	Kpol_1035p32	ABC transporter domain-containing protein. (280 aa)
	Kpol_1041p42	AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
	Kpol_1041p45	Uncharacterized protein. (1596 aa)
	Kpol_1020p9	Uncharacterized protein; Belongs to the AAA ATPase family. (812 aa)
	Kpol_1056p21	Uncharacterized protein. (1064 aa)
	Kpol_1052p6	Uncharacterized protein. (763 aa)
	Kpol_1052p39	Uncharacterized protein; Belongs to the RecA family. (334 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (632 aa)
	Kpol_1064p22	AAA domain-containing protein; Belongs to the AAA ATPase family. (432 aa)
	Kpol_513p9	Uncharacterized protein; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1513 aa)
	Kpol_513p19	Bromo domain-containing protein. (1377 aa)
	Kpol_1066p38	AAA domain-containing protein. (336 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kpol_1001p11	Kpol_1010p74	A7TNP8	A7TIL8	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.546
Kpol_1001p11	Kpol_1032p87	A7TNP8	A7TH38	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.546
Kpol_1001p11	Kpol_1041p42	A7TNP8	A7TLA9	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.549
Kpol_1001p11	Kpol_1048p53	A7TNP8	A7TGL5	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.584
Kpol_1001p11	Kpol_1059p29	A7TNP8	A7TN33	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Replication factor C subunit 1.	0.403
Kpol_1001p11	Kpol_1064p22	A7TNP8	A7TME7	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.510
Kpol_1001p11	Kpol_2002p52	A7TNP8	A7TFG7	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.999
Kpol_1001p11	Kpol_264p5	A7TNP8	A7TSY8	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	AAA domain-containing protein.	0.520
Kpol_1001p11	Kpol_431p4	A7TNP8	A7TRM5	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	AAA domain-containing protein.	0.406
Kpol_1001p11	Kpol_513p19	A7TNP8	A7TMK5	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Bromo domain-containing protein.	0.440
Kpol_1001p11	MCM7	A7TNP8	A7TQV0	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
Kpol_1002p105	Kpol_1002p29	A7TED4	A7TE61	Uncharacterized protein.	Uncharacterized protein.	0.766
Kpol_1002p105	Kpol_1032p48	A7TED4	A7TH02	Uncharacterized protein.	Uncharacterized protein.	0.682
Kpol_1002p105	Kpol_1035p32	A7TED4	A7TKJ7	Uncharacterized protein.	ABC transporter domain-containing protein.	0.472
Kpol_1002p105	Kpol_1048p72	A7TED4	A7TGN4	Uncharacterized protein.	Uncharacterized protein.	0.681
Kpol_1002p105	Kpol_1050p16	A7TED4	A7TER3	Uncharacterized protein.	ABC transporter domain-containing protein.	0.453
Kpol_1002p105	Kpol_487p13	A7TED4	A7TQ88	Uncharacterized protein.	Uncharacterized protein.	0.681
Kpol_1002p29	Kpol_1002p105	A7TE61	A7TED4	Uncharacterized protein.	Uncharacterized protein.	0.766
Kpol_1002p29	Kpol_1012p10	A7TE61	A7TS82	Uncharacterized protein.	ABC transporter domain-containing protein.	0.560
Kpol_1002p29	Kpol_1018p70	A7TE61	A7TDR8	Uncharacterized protein.	Uncharacterized protein; Belongs to the ClpA/ClpB family.	0.657