(46 nodes) Alpha/Beta hydrolase fold network (Vanderwaltozyma polyspora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kpol_1064p47	FSH1 domain-containing protein. (219 aa)
	Kpol_1064p36	AB hydrolase-1 domain-containing protein. (457 aa)
	KEX1	Pheromone-processing carboxypeptidase KEX1; Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). (713 aa)
	Kpol_1072p38	Uncharacterized protein; Belongs to the peptidase S9B family. (897 aa)
	Kpol_1072p23	Uncharacterized protein. (288 aa)
	Kpol_1035p43	Uncharacterized protein. (1094 aa)
	Kpol_1035p9	AB hydrolase-1 domain-containing protein. (427 aa)
	Kpol_538p41	DLH domain-containing protein. (251 aa)
	Kpol_1062p36	AB hydrolase-1 domain-containing protein. (328 aa)
	Kpol_1058p55	DLH domain-containing protein. (273 aa)
	Kpol_1058p23	GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. (1006 aa)
	Kpol_1058p18	Uncharacterized protein. (642 aa)
	Kpol_534p12	DUF676 domain-containing protein. (708 aa)
	Kpol_1004p47	DUF676 domain-containing protein. (675 aa)
	Kpol_1004p42	Uncharacterized protein. (639 aa)
	BNA7	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (261 aa)
	Kpol_1043p65	AB hydrolase-1 domain-containing protein. (383 aa)
	Kpol_543p59	Abhydrolase_2 domain-containing protein. (228 aa)
	Kpol_543p49	AB hydrolase-1 domain-containing protein. (429 aa)
	Kpol_1048p43	AB hydrolase-1 domain-containing protein. (451 aa)
	Kpol_1028p87	Lipase_3 domain-containing protein. (447 aa)
	Kpol_2000p31	Uncharacterized protein. (693 aa)
	Kpol_2000p45	DUF676 domain-containing protein. (406 aa)
	Kpol_2000p78	AB hydrolase-1 domain-containing protein. (495 aa)
	Kpol_2002p98	Abhydro_lipase domain-containing protein. (568 aa)
	ATG15	Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (565 aa)
	Kpol_1028p72	Carboxypeptidase; Belongs to the peptidase S10 family. (533 aa)
	Kpol_1018p63	DDHD domain-containing protein. (669 aa)
	Kpol_1036p14	Carboxypeptidase; Belongs to the peptidase S10 family. (491 aa)
	Kpol_299p6	AB hydrolase-1 domain-containing protein. (349 aa)
	Kpol_297p4	AB hydrolase-1 domain-containing protein. (533 aa)
	Kpol_385p12	AB hydrolase-1 domain-containing protein. (310 aa)
	Kpol_413p12	FSH1 domain-containing protein. (273 aa)
	Kpol_1038p19	Hydrolase_4 domain-containing protein. (287 aa)
	Kpol_1042p24	Hydrolase_4 domain-containing protein. (311 aa)
	Kpol_483p7	Uncharacterized protein. (638 aa)
	Kpol_473p17	DUF676 domain-containing protein. (518 aa)
	Kpol_1049p7	DLH domain-containing protein. (212 aa)
	Kpol_478p15	Abhydro_lipase domain-containing protein. (487 aa)
	Kpol_480p17	Uncharacterized protein. (313 aa)
	Kpol_1067p12	Uncharacterized protein. (389 aa)
	Kpol_505p17	AB hydrolase-1 domain-containing protein. (631 aa)
	Kpol_1051p23	Uncharacterized protein; Belongs to the peptidase S9B family. (826 aa)
	Kpol_1051p16	FSH1 domain-containing protein. (244 aa)
	Kpol_1030p46	AB hydrolase-1 domain-containing protein. (369 aa)
	Kpol_1066p25	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (297 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG15	Kpol_1042p24	A7TG13	A7TQA9	Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	Hydrolase_4 domain-containing protein.	0.900
ATG15	Kpol_2000p45	A7TG13	A7TF55	Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	DUF676 domain-containing protein.	0.900
BNA7	Kpol_1043p65	A7TJ85	A7TIT2	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	AB hydrolase-1 domain-containing protein.	0.454
BNA7	Kpol_1066p25	A7TJ85	A7TMP6	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.466
KEX1	Kpol_1072p38	A7TLB3	A7TKQ6	Pheromone-processing carboxypeptidase KEX1; Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).	Uncharacterized protein; Belongs to the peptidase S9B family.	0.493
Kpol_1038p19	Kpol_1042p24	A7TR09	A7TQA9	Hydrolase_4 domain-containing protein.	Hydrolase_4 domain-containing protein.	0.529
Kpol_1038p19	Kpol_2000p45	A7TR09	A7TF55	Hydrolase_4 domain-containing protein.	DUF676 domain-containing protein.	0.505
Kpol_1038p19	Kpol_543p59	A7TR09	A7THR3	Hydrolase_4 domain-containing protein.	Abhydrolase_2 domain-containing protein.	0.704
Kpol_1042p24	ATG15	A7TQA9	A7TG13	Hydrolase_4 domain-containing protein.	Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.	0.900
Kpol_1042p24	Kpol_1038p19	A7TQA9	A7TR09	Hydrolase_4 domain-containing protein.	Hydrolase_4 domain-containing protein.	0.529
Kpol_1042p24	Kpol_1043p65	A7TQA9	A7TIT2	Hydrolase_4 domain-containing protein.	AB hydrolase-1 domain-containing protein.	0.528
Kpol_1042p24	Kpol_1064p36	A7TQA9	A7TMG0	Hydrolase_4 domain-containing protein.	AB hydrolase-1 domain-containing protein.	0.507
Kpol_1042p24	Kpol_2000p45	A7TQA9	A7TF55	Hydrolase_4 domain-containing protein.	DUF676 domain-containing protein.	0.943
Kpol_1042p24	Kpol_505p17	A7TQA9	A7TNA8	Hydrolase_4 domain-containing protein.	AB hydrolase-1 domain-containing protein.	0.405
Kpol_1043p65	BNA7	A7TIT2	A7TJ85	AB hydrolase-1 domain-containing protein.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.454
Kpol_1043p65	Kpol_1042p24	A7TIT2	A7TQA9	AB hydrolase-1 domain-containing protein.	Hydrolase_4 domain-containing protein.	0.528
Kpol_1043p65	Kpol_1067p12	A7TIT2	A7TNV7	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.454
Kpol_1064p36	Kpol_1042p24	A7TMG0	A7TQA9	AB hydrolase-1 domain-containing protein.	Hydrolase_4 domain-containing protein.	0.507
Kpol_1066p25	BNA7	A7TMP6	A7TJ85	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.466
Kpol_1066p25	Kpol_1067p12	A7TMP6	A7TNV7	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	Uncharacterized protein.	0.466