(10 nodes) Assembly of the ORC complex at the origin of replication network (Vanderwaltozyma polyspora)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	Kpol_2000p53	AAA_16 domain-containing protein. (480 aa)
	Kpol_1048p19	Uncharacterized protein. (446 aa)
	Kpol_1031p52	Histone H2B; Belongs to the histone H2B family. (130 aa)
	Kpol_534p55	ORC_WH_C domain-containing protein. (625 aa)
	Kpol_1041p13	Importin subunit alpha; Belongs to the importin alpha family. (545 aa)
	Kpol_529p3	Histone H2B; Belongs to the histone H2B family. (128 aa)
	Kpol_520p35	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (971 aa)
	Kpol_1001p11	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (920 aa)
	Kpol_1008p15	ORC4_C domain-containing protein. (579 aa)
	Kpol_251p3	Uncharacterized protein. (680 aa)

Your Current Organism:

Vanderwaltozyma polyspora

NCBI taxonomy Id: 436907
Other names: V. polyspora DSM 70294, Vanderwaltozyma polyspora DSM 70294, Vanderwaltozyma polyspora DSMZ 70294

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Kpol_1001p11	Kpol_1008p15	A7TNP8	A7TPX9	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	ORC4_C domain-containing protein.	0.999
Kpol_1001p11	Kpol_1031p52	A7TNP8	A7THY3	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Histone H2B; Belongs to the histone H2B family.	0.704
Kpol_1001p11	Kpol_1041p13	A7TNP8	A7TL80	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Importin subunit alpha; Belongs to the importin alpha family.	0.560
Kpol_1001p11	Kpol_1048p19	A7TNP8	A7TGI2	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Uncharacterized protein.	0.999
Kpol_1001p11	Kpol_2000p53	A7TNP8	A7TF61	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	AAA_16 domain-containing protein.	0.999
Kpol_1001p11	Kpol_251p3	A7TNP8	A7TTD2	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Uncharacterized protein.	0.999
Kpol_1001p11	Kpol_529p3	A7TNP8	A7TM56	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	Histone H2B; Belongs to the histone H2B family.	0.557
Kpol_1001p11	Kpol_534p55	A7TNP8	A7TJN1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	ORC_WH_C domain-containing protein.	0.999
Kpol_1008p15	Kpol_1001p11	A7TPX9	A7TNP8	ORC4_C domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.999
Kpol_1008p15	Kpol_1041p13	A7TPX9	A7TL80	ORC4_C domain-containing protein.	Importin subunit alpha; Belongs to the importin alpha family.	0.626
Kpol_1008p15	Kpol_1048p19	A7TPX9	A7TGI2	ORC4_C domain-containing protein.	Uncharacterized protein.	0.999
Kpol_1008p15	Kpol_2000p53	A7TPX9	A7TF61	ORC4_C domain-containing protein.	AAA_16 domain-containing protein.	0.999
Kpol_1008p15	Kpol_251p3	A7TPX9	A7TTD2	ORC4_C domain-containing protein.	Uncharacterized protein.	0.999
Kpol_1008p15	Kpol_520p35	A7TPX9	A7TMB8	ORC4_C domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.962
Kpol_1008p15	Kpol_534p55	A7TPX9	A7TJN1	ORC4_C domain-containing protein.	ORC_WH_C domain-containing protein.	0.999
Kpol_1031p52	Kpol_1001p11	A7THY3	A7TNP8	Histone H2B; Belongs to the histone H2B family.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.704
Kpol_1031p52	Kpol_520p35	A7THY3	A7TMB8	Histone H2B; Belongs to the histone H2B family.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.557
Kpol_1041p13	Kpol_1001p11	A7TL80	A7TNP8	Importin subunit alpha; Belongs to the importin alpha family.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.560
Kpol_1041p13	Kpol_1008p15	A7TL80	A7TPX9	Importin subunit alpha; Belongs to the importin alpha family.	ORC4_C domain-containing protein.	0.626
Kpol_1041p13	Kpol_2000p53	A7TL80	A7TF61	Importin subunit alpha; Belongs to the importin alpha family.	AAA_16 domain-containing protein.	0.648