(59 nodes) RNA polymerase II, holoenzyme network (Monopterus albus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	gtf2e2	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (287 aa)
	rprd1b	Regulation of nuclear pre-mRNA domain containing 1B. (328 aa)
	rpap2	RNA polymerase II associated protein 2. (297 aa)
	sh3bp5l	SH3-binding domain protein 5-like, a. (410 aa)
	gtf2a1l	General transcription factor IIA, 1-like. (453 aa)
	taf5	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (761 aa)
	LOC109968291	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (254 aa)
	ENSMALP00000006749	TAF4 domain-containing protein. (298 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	polr2k	Uncharacterized protein. (69 aa)
	tbp	TATA box binding protein. (325 aa)
	taf13	TATA-box binding protein associated factor 13. (124 aa)
	ENSMALP00000009793	Peroxisomal biogenesis factor 2. (361 aa)
	rprd2	Regulation of nuclear pre-mRNA domain containing 2b. (1184 aa)
	ENSMALP00000010360	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (176 aa)
	cdc73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (534 aa)
	LOC109959671	General transcription factor IIH subunit. (393 aa)
	LOC109951387	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1973 aa)
	taf5l	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (574 aa)
	cinp	Cyclin-dependent kinase 2 interacting protein. (207 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (319 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
	taf3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto. (931 aa)
	LOC109951497	CID domain-containing protein. (446 aa)
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (589 aa)
	paf1	PAF1 homolog, Paf1/RNA polymerase II complex component. (529 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (288 aa)
	taf2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (1128 aa)
	LOC109969637	Uncharacterized protein. (322 aa)
	polr2g	Polymerase (RNA) II (DNA directed) polypeptide G-like. (172 aa)
	LOC109958284	Uncharacterized protein. (894 aa)
	ENSMALP00000020384	TAF4 domain-containing protein. (269 aa)
	ENSMALP00000020829	TAF4 domain-containing protein. (282 aa)
	gtf2f2	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (270 aa)
	ercc3	Excision repair cross-complementation group 3. (781 aa)
	gtf2a2	General transcription factor IIA, 2. (210 aa)
	wdr61	WD repeat domain 61. (305 aa)
	rprd1a	Regulation of nuclear pre-mRNA domain containing 1A. (274 aa)
	ENSMALP00000023076	Protein kinase domain-containing protein. (126 aa)
	Gtf2a1	Uncharacterized protein. (60 aa)
	cdk20	Cyclin-dependent kinase 20; Belongs to the protein kinase superfamily. (344 aa)
	polr2d	Polymerase (RNA) II (DNA directed) polypeptide D. (144 aa)
	gtf2e1	General transcription factor IIE, polypeptide 1, alpha. (447 aa)
	taf8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (308 aa)
	LOC109959484	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (1789 aa)
	wdr47	WD repeat domain 47a. (912 aa)
	recql5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (779 aa)
	polr2b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (461 aa)
	ctr9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1050 aa)
	ENSMALP00000029992	Polymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
	rtf1	Plus3 domain-containing protein. (641 aa)
	polr2m	RNA polymerase II subunit M. (355 aa)
	POLR2E	RNA polymerase II subunit E. (210 aa)
	supt3h	Uncharacterized protein. (379 aa)
	TAF4	TATA-box binding protein associated factor 4. (968 aa)
	taf11	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (233 aa)

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMALP00000006749	ENSMALP00000023076	ENSMALP00000006749	ENSMALP00000023076	TAF4 domain-containing protein.	Protein kinase domain-containing protein.	0.581
ENSMALP00000006749	ENSMALP00000029992	ENSMALP00000006749	ENSMALP00000029992	TAF4 domain-containing protein.	Polymerase (RNA) II (DNA directed) polypeptide J.	0.786
ENSMALP00000006749	Gtf2a1	ENSMALP00000006749	ENSMALP00000025640	TAF4 domain-containing protein.	Uncharacterized protein.	0.782
ENSMALP00000006749	LOC109951387	ENSMALP00000006749	ENSMALP00000012348	TAF4 domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.756
ENSMALP00000006749	LOC109959484	ENSMALP00000006749	ENSMALP00000027586	TAF4 domain-containing protein.	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.959
ENSMALP00000006749	LOC109959671	ENSMALP00000006749	ENSMALP00000011164	TAF4 domain-containing protein.	General transcription factor IIH subunit.	0.715
ENSMALP00000006749	LOC109968291	ENSMALP00000006749	ENSMALP00000006236	TAF4 domain-containing protein.	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	0.741
ENSMALP00000006749	LOC109969637	ENSMALP00000006749	ENSMALP00000019047	TAF4 domain-containing protein.	Uncharacterized protein.	0.805
ENSMALP00000006749	POLR2E	ENSMALP00000006749	ENSMALP00000031719	TAF4 domain-containing protein.	RNA polymerase II subunit E.	0.719
ENSMALP00000006749	ccnh	ENSMALP00000006749	ENSMALP00000013404	TAF4 domain-containing protein.	Cyclin H; Belongs to the cyclin family.	0.715
ENSMALP00000006749	cdk20	ENSMALP00000006749	ENSMALP00000026042	TAF4 domain-containing protein.	Cyclin-dependent kinase 20; Belongs to the protein kinase superfamily.	0.600
ENSMALP00000006749	cdk7	ENSMALP00000006749	ENSMALP00000015636	TAF4 domain-containing protein.	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily.	0.600
ENSMALP00000006749	ercc3	ENSMALP00000006749	ENSMALP00000021394	TAF4 domain-containing protein.	Excision repair cross-complementation group 3.	0.719
ENSMALP00000006749	gtf2a1l	ENSMALP00000006749	ENSMALP00000005318	TAF4 domain-containing protein.	General transcription factor IIA, 1-like.	0.803
ENSMALP00000006749	gtf2a2	ENSMALP00000006749	ENSMALP00000021521	TAF4 domain-containing protein.	General transcription factor IIA, 2.	0.840
ENSMALP00000006749	gtf2e1	ENSMALP00000006749	ENSMALP00000027099	TAF4 domain-containing protein.	General transcription factor IIE, polypeptide 1, alpha.	0.708
ENSMALP00000006749	gtf2e2	ENSMALP00000006749	ENSMALP00000002688	TAF4 domain-containing protein.	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.	0.813
ENSMALP00000006749	gtf2f2	ENSMALP00000006749	ENSMALP00000021248	TAF4 domain-containing protein.	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.	0.741
ENSMALP00000006749	gtf2h1	ENSMALP00000006749	ENSMALP00000007667	TAF4 domain-containing protein.	General transcription factor IIH, polypeptide 1.	0.719
ENSMALP00000006749	gtf2h3	ENSMALP00000006749	ENSMALP00000017070	TAF4 domain-containing protein.	General transcription factor IIH, polypeptide 3.	0.740