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| | Mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (569 aa) |
| | LOC109967672 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | pias4 | Protein inhibitor of activated STAT, 4a. (481 aa) |
| | ENSMALP00000011733 | Uncharacterized protein. (92 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (616 aa) |
| | ENSMALP00000011910 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (110 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (873 aa) |
| | ENSMALP00000012212 | Uncharacterized protein. (238 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (331 aa) |
| | ppp4r2 | Protein phosphatase 4, regulatory subunit 2b. (403 aa) |
| | cdca7 | Cell division cycle associated 7a. (409 aa) |
| | ENSMALP00000013776 | TAN domain-containing protein. (131 aa) |
| | Atm | Uncharacterized protein. (132 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1501 aa) |
| | polk | Polymerase (DNA directed) kappa. (884 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (708 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | rpa3 | Uncharacterized protein. (135 aa) |
| | ccna1 | Cyclin A1; Belongs to the cyclin family. (416 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (627 aa) |
| | rcbtb2 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa) |
| | LOC109966759 | Uncharacterized protein. (400 aa) |
| | rad51d | RAD51 paralog D. (323 aa) |
| | lig3 | DNA ligase. (1013 aa) |
| | ube2n | Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2613 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (599 aa) |
| | ENSMALP00000016949 | Histone H2A; Belongs to the histone H2A family. (141 aa) |
| | rpa2 | Replication protein A2. (278 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1078 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2210 aa) |
| | ENSMALP00000019196 | RECA_2 domain-containing protein. (258 aa) |
| | rhno1 | Si:ch73-352p4.5. (299 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa) |
| | pold4 | Si:dkey-28b4.7. (106 aa) |
| | ENSMALP00000020293 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (577 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (526 aa) |
| | ENSMALP00000020785 | Histone H2B; Belongs to the histone H2B family. (115 aa) |
| | rad51c | RAD51 paralog C. (350 aa) |
| | rps27a | Ribosomal protein S27a. (156 aa) |
| | ENSMALP00000021124 | RAD51_interact domain-containing protein. (221 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa) |
| | tdrd3 | Tudor domain containing 3. (761 aa) |
| | Polh | Polymerase (DNA directed), eta. (297 aa) |
| | LOC109959903 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa) |
| | ankrd12 | ANK_REP_REGION domain-containing protein. (487 aa) |
| | ENSMALP00000023295 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa) |
| | cdca7l | Cell division cycle associated 7b. (397 aa) |
| | LOC109957172 | Small ubiquitin-related modifier. (95 aa) |
| | LOC109967477 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (153 aa) |
| | LOC109967476 | CBFD_NFYB_HMF domain-containing protein. (132 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (435 aa) |
| | ENSMALP00000024613 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (513 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (565 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (357 aa) |
| | LOC109968062 | Small ubiquitin-related modifier. (108 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | timeless | Timeless circadian clock. (1175 aa) |
| | uba52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (404 aa) |
| | Brca2 | Uncharacterized protein. (1262 aa) |
| | ENSMALP00000026641 | BRCA-2_OB1 domain-containing protein. (311 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | palb2 | Uncharacterized protein. (1046 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (257 aa) |
| | Rnf168 | RING-type domain-containing protein. (111 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (467 aa) |
| | rad1 | RAD1 homolog (S. pombe). (287 aa) |
| | LOC109957254 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (258 aa) |
| | pold1 | DNA polymerase. (1080 aa) |
| | uimc1 | Uncharacterized protein. (1052 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (370 aa) |
| | rmi2 | RecQ mediated genome instability 2. (139 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (921 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | exo1 | Exonuclease 1. (810 aa) |
| | sirt6 | Sirtuin 6. (345 aa) |
| | LOC109957769 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | LOC109960591 | Tyrosine-protein kinase. (1102 aa) |
| | brca1 | Uncharacterized protein. (1177 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (639 aa) |
| | LOC109952335 | Histone H2B; Belongs to the histone H2B family. (123 aa) |
| | mdc1 | Uncharacterized protein. (2021 aa) |
| | LOC109966247 | Small ubiquitin-related modifier. (124 aa) |
| | atrip | Uncharacterized protein. (545 aa) |
| | Brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (286 aa) |
| | EME2 | ERCC4 domain-containing protein. (434 aa) |
| | ENSMALP00000001069 | BTB domain-containing protein. (1162 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (718 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa) |
| | gen1 | Uncharacterized protein. (923 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (311 aa) |
| | ube2i | Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | ENSMALP00000003154 | Histone H2B; Belongs to the histone H2B family. (128 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (155 aa) |
| | LOC109969319 | Zgc:110269. (337 aa) |
| | ENSMALP00000004273 | SAE2 domain-containing protein. (75 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (376 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (317 aa) |
| | nsd2 | Nuclear receptor binding SET domain protein 2. (1121 aa) |
| | parp1 | Poly [ADP-ribose] polymerase. (1018 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (519 aa) |
| | ENSMALP00000006512 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa) |
| | kxd1 | KxDL motif containing 1. (184 aa) |
| | Bre | BRISC and BRCA1 A complex member 2. (383 aa) |
| | LOC109963691 | RPA_C domain-containing protein. (298 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (437 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (358 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | sirt7 | Sirtuin 7. (951 aa) |
| | dna2 | DNA replication helicase/nuclease 2. (1400 aa) |
| | sumo2 | Small ubiquitin-related modifier. (95 aa) |
| | LOC109974756 | Uncharacterized protein. (245 aa) |
| | ENSMALP00000009000 | Reverse transcriptase domain-containing protein. (160 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1447 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (436 aa) |
| | rfc1 | Replication factor C subunit 1. (1086 aa) |
| | LOC109959667 | ANK_REP_REGION domain-containing protein. (684 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (461 aa) |
| | blm | BLM RecQ like helicase. (1381 aa) |
| | ENSMALP00000010367 | RecQ helicase-like 4. (794 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (671 aa) |
| | LOC109974159 | Polymerase (DNA directed), theta. (2810 aa) |
| | LOC109972417 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | LOC109955588 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (528 aa) |
