STRINGSTRING
LOC109967672 LOC109967672 LOC109959903 LOC109959903 pias4 pias4 ENSMALP00000011733 ENSMALP00000011733 ENSMALP00000011910 ENSMALP00000011910 tp53 tp53 ENSMALP00000012212 ENSMALP00000012212 ENSMALP00000013776 ENSMALP00000013776 mdc1 mdc1 LOC109952335 LOC109952335 brca1 brca1 LOC109960591 LOC109960591 LOC109957769 LOC109957769 ube2v2 ube2v2 babam1 babam1 uimc1 uimc1 rnf8 rnf8 Rnf168 Rnf168 rad50 rad50 uba52 uba52 kat5 kat5 ENSMALP00000024613 ENSMALP00000024613 ENSMALP00000023295 ENSMALP00000023295 apbb1 apbb1 ankrd12 ankrd12 Atm Atm tp53bp1 tp53bp1 ppp5c ppp5c ube2n ube2n eya4 eya4 LOC109973983 LOC109973983 ENSMALP00000016949 ENSMALP00000016949 LOC109958648 LOC109958648 LOC109958225 LOC109958225 ENSMALP00000020293 ENSMALP00000020293 ENSMALP00000020785 ENSMALP00000020785 rps27a rps27a Brcc3 Brcc3 eya1 eya1 ube2i ube2i smarca5 smarca5 LOC109957388 LOC109957388 ENSMALP00000003154 ENSMALP00000003154 baz1b baz1b nsd2 nsd2 sumo1 sumo1 ENSMALP00000006512 ENSMALP00000006512 kxd1 kxd1 Bre Bre LOC109974756 LOC109974756 ENSMALP00000009000 ENSMALP00000009000 LOC109959667 LOC109959667 LOC109972417 LOC109972417 Mre11 Mre11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC109967672Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC109959903UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
pias4Protein inhibitor of activated STAT, 4a. (481 aa)
ENSMALP00000011733Uncharacterized protein. (92 aa)
ENSMALP00000011910Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (110 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (374 aa)
ENSMALP00000012212Uncharacterized protein. (238 aa)
ENSMALP00000013776TAN domain-containing protein. (131 aa)
mdc1Uncharacterized protein. (2021 aa)
LOC109952335Histone H2B; Belongs to the histone H2B family. (123 aa)
brca1Uncharacterized protein. (1177 aa)
LOC109960591Tyrosine-protein kinase. (1102 aa)
LOC109957769Histone H2B; Belongs to the histone H2B family. (134 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
babam1BRISC and BRCA1 A complex member 1. (370 aa)
uimc1Uncharacterized protein. (1052 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (467 aa)
Rnf168RING-type domain-containing protein. (111 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (565 aa)
ENSMALP00000024613Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSMALP00000023295Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
apbb1Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (669 aa)
ankrd12ANK_REP_REGION domain-containing protein. (487 aa)
AtmUncharacterized protein. (132 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1501 aa)
ppp5cSerine/threonine-protein phosphatase. (371 aa)
ube2nUbiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (628 aa)
LOC109973983Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (499 aa)
ENSMALP00000016949Histone H2A; Belongs to the histone H2A family. (141 aa)
LOC109958648Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (602 aa)
LOC109958225Lysine (K)-specific demethylase 4B. (1223 aa)
ENSMALP00000020293Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
ENSMALP00000020785Histone H2B; Belongs to the histone H2B family. (115 aa)
rps27aRibosomal protein S27a. (156 aa)
Brcc3BRCA1/BRCA2-containing complex, subunit 3. (286 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (577 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1033 aa)
LOC109957388Checkpoint kinase 2. (537 aa)
ENSMALP00000003154Histone H2B; Belongs to the histone H2B family. (128 aa)
baz1bBromodomain adjacent to zinc finger domain, 1B. (1580 aa)
nsd2Nuclear receptor binding SET domain protein 2. (1121 aa)
sumo1Small ubiquitin-related modifier. (101 aa)
ENSMALP00000006512Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
kxd1KxDL motif containing 1. (184 aa)
BreBRISC and BRCA1 A complex member 2. (383 aa)
LOC109974756Uncharacterized protein. (245 aa)
ENSMALP00000009000Reverse transcriptase domain-containing protein. (160 aa)
LOC109959667ANK_REP_REGION domain-containing protein. (684 aa)
LOC109972417UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
Mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (569 aa)
Your Current Organism:
Monopterus albus
NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.