STRINGSTRING
LOC109951455 LOC109951455 rpa3 rpa3 psme2 psme2 rfc3 rfc3 rmi1 rmi1 mcm10 mcm10 tp53bp1 tp53bp1 Atm Atm ENSMALP00000013776 ENSMALP00000013776 psme3 psme3 cdc6 cdc6 cdca7 cdca7 rfc4 rfc4 psmd8 psmd8 ENSMALP00000012212 ENSMALP00000012212 tp53 tp53 slf1 slf1 ENSMALP00000011910 ENSMALP00000011910 ENSMALP00000011733 ENSMALP00000011733 pias4 pias4 LOC109967672 LOC109967672 pkmyt1 pkmyt1 LOC109955588 LOC109955588 Mre11 Mre11 rad17 rad17 ENSMALP00000010367 ENSMALP00000010367 blm blm chek1 chek1 ENSMALP00000004828 ENSMALP00000004828 ENSMALP00000004856 ENSMALP00000004856 mcm6 mcm6 psma2 psma2 mcm5 mcm5 RCBTB1 RCBTB1 orc4 orc4 LOC109959667 LOC109959667 topbp1 topbp1 psmd10 psmd10 LOC109972395 LOC109972395 ENSMALP00000009000 ENSMALP00000009000 psmb1 psmb1 psmc3 psmc3 LOC109974756 LOC109974756 LOC109958608 LOC109958608 dna2 dna2 psmb3 psmb3 LOC109954191 LOC109954191 rfc5 rfc5 LOC109954172 LOC109954172 LOC109954169 LOC109954169 mcm9 mcm9 psmd7 psmd7 LOC109963691 LOC109963691 ENSMALP00000006512 ENSMALP00000006512 psmd5 psmd5 psmb6 psmb6 Bre Bre kxd1 kxd1 Brcc3 Brcc3 wdr41 wdr41 LOC109953656 LOC109953656 psmd3 psmd3 RPA1 RPA1 LOC109957388 LOC109957388 ENSMALP00000003154 ENSMALP00000003154 cdc7 cdc7 LOC109960805 LOC109960805 ENSMALP00000003655 ENSMALP00000003655 dbf4 dbf4 ccnb2 ccnb2 CDC25B CDC25B psme1 psme1 psmd6 psmd6 ENSMALP00000004273 ENSMALP00000004273 rad9b rad9b LOC109964116 LOC109964116 CCNB2 CCNB2 psme4 psme4 ENSMALP00000004719 ENSMALP00000004719 nsd2 nsd2 ENSMALP00000024613 ENSMALP00000024613 psmd1 psmd1 psmc6 psmc6 LOC109972097 LOC109972097 cdca7l cdca7l ENSMALP00000023295 ENSMALP00000023295 ankrd12 ankrd12 LOC109959903 LOC109959903 ENSMALP00000022478 ENSMALP00000022478 PIEZO2 PIEZO2 tdrd3 tdrd3 rps27a rps27a LOC109963380 LOC109963380 orc5 orc5 ENSMALP00000020785 ENSMALP00000020785 psmd14 psmd14 psmd12 psmd12 ENSMALP00000020293 ENSMALP00000020293 LOC109962028 LOC109962028 rad9a rad9a hus1 hus1 rhno1 rhno1 ENSMALP00000019113 ENSMALP00000019113 LOC109962801 LOC109962801 ywhaz ywhaz ccnb3 ccnb3 orc2 orc2 top3a top3a cntd2 cntd2 rpa2 rpa2 psmb4 psmb4 psmc2 psmc2 orc3 orc3 LOC109959349 LOC109959349 wee1 wee1 psmb2 psmb2 psmd9 psmd9 CLSPN CLSPN piezo1 piezo1 cdc45 cdc45 LOC109951222 LOC109951222 rnf8 rnf8 rad1 rad1 psma5 psma5 PSMD14 PSMD14 uimc1 uimc1 psmc4 psmc4 babam1 babam1 rmi2 rmi2 mcm4 mcm4 ube2v2 ube2v2 exo1 exo1 psmc5 psmc5 LOC109961851 LOC109961851 LOC109957769 LOC109957769 YWHAB YWHAB psma6 psma6 mcm8 mcm8 LOC109951458 LOC109951458 brca1 brca1 exd2 exd2 LOC109952335 LOC109952335 mdc1 mdc1 atrip atrip ccnb1 ccnb1 Rnf168 Rnf168 psmd13 psmd13 orc1 orc1 LOC109973907 LOC109973907 psma8 psma8 psma3 psma3 rad50 rad50 mcm3 mcm3 mcm7 mcm7 meiob meiob psmc1 psmc1 LOC109969836 LOC109969836 cdk2 cdk2 rfc2 rfc2 kat5 kat5 psma1 psma1 ENSMALP00000016949 ENSMALP00000016949 rpa1 rpa1 atr atr cdk1 cdk1 ywhaq ywhaq ube2n ube2n mcm2 mcm2 ENSMALP00000015333 ENSMALP00000015333 rcbtb2 rcbtb2 psmf1 psmf1 LOC109962656 LOC109962656
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC109951455PCI domain-containing protein. (425 aa)
rpa3Uncharacterized protein. (135 aa)
psme2Proteasome activator subunit 2. (245 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (708 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (915 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1501 aa)
AtmUncharacterized protein. (132 aa)
ENSMALP00000013776TAN domain-containing protein. (131 aa)
psme3Proteasome activator subunit 3. (260 aa)
cdc6Cell division cycle 6 homolog (S. cerevisiae). (410 aa)
cdca7Cell division cycle associated 7a. (409 aa)
rfc4Replication factor C (activator 1) 4. (331 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (281 aa)
ENSMALP00000012212Uncharacterized protein. (238 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (374 aa)
slf1SMC5-SMC6 complex localization factor 1. (873 aa)
ENSMALP00000011910Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (110 aa)
ENSMALP00000011733Uncharacterized protein. (92 aa)
pias4Protein inhibitor of activated STAT, 4a. (481 aa)
LOC109967672Histone H2B; Belongs to the histone H2B family. (124 aa)
pkmyt1Protein kinase, membrane associated tyrosine/threonine 1. (589 aa)
LOC109955588Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (528 aa)
Mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (569 aa)
rad17RAD17 checkpoint clamp loader component. (671 aa)
ENSMALP00000010367RecQ helicase-like 4. (794 aa)
blmBLM RecQ like helicase. (1381 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (461 aa)
ENSMALP00000004828Piezo_RRas_bdg domain-containing protein. (607 aa)
ENSMALP00000004856Uncharacterized protein. (302 aa)
mcm6DNA helicase; Belongs to the MCM family. (831 aa)
psma2Proteasome subunit alpha type. (234 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (519 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
LOC109959667ANK_REP_REGION domain-containing protein. (684 aa)
topbp1DNA topoisomerase II binding protein 1. (1447 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (226 aa)
LOC10997239514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (243 aa)
ENSMALP00000009000Reverse transcriptase domain-containing protein. (160 aa)
psmb1Proteasome subunit beta. (220 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
LOC109974756Uncharacterized protein. (245 aa)
LOC109958608Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (254 aa)
dna2DNA replication helicase/nuclease 2. (1400 aa)
psmb3Proteasome subunit beta. (202 aa)
LOC109954191Proteasome endopeptidase complex. (99 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
LOC109954172Proteasome subunit beta 12. (168 aa)
LOC109954169Proteasome subunit beta 9a. (95 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1366 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (327 aa)
LOC109963691RPA_C domain-containing protein. (298 aa)
ENSMALP00000006512Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
psmb6Proteasome subunit beta. (225 aa)
BreBRISC and BRCA1 A complex member 2. (383 aa)
kxd1KxDL motif containing 1. (184 aa)
Brcc3BRCA1/BRCA2-containing complex, subunit 3. (286 aa)
wdr41WD repeat domain 41. (412 aa)
LOC109953656Proteasome subunit beta. (286 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (518 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (718 aa)
LOC109957388Checkpoint kinase 2. (537 aa)
ENSMALP00000003154Histone H2B; Belongs to the histone H2B family. (128 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (610 aa)
LOC109960805Proteasome subunit beta. (284 aa)
ENSMALP00000003655Uncharacterized protein. (88 aa)
dbf4DBF4-type domain-containing protein. (426 aa)
ccnb2Cyclin B2; Belongs to the cyclin family. (390 aa)
CDC25BCell division cycle 25B. (559 aa)
psme1Proteasome activator subunit 1. (250 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
ENSMALP00000004273SAE2 domain-containing protein. (75 aa)
rad9bRAD9 checkpoint clamp component B. (376 aa)
LOC109964116Proteasome 26S subunit, non-ATPase 4b. (375 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (380 aa)
psme4Proteasome activator subunit 4a. (1754 aa)
ENSMALP00000004719Uncharacterized protein. (121 aa)
nsd2Nuclear receptor binding SET domain protein 2. (1121 aa)
ENSMALP00000024613Histone H2B; Belongs to the histone H2B family. (124 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (959 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
LOC1099720973-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
cdca7lCell division cycle associated 7b. (397 aa)
ENSMALP00000023295Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
ankrd12ANK_REP_REGION domain-containing protein. (487 aa)
LOC109959903UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
ENSMALP00000022478Uncharacterized protein. (550 aa)
PIEZO2Piezo type mechanosensitive ion channel component 2. (1383 aa)
tdrd3Tudor domain containing 3. (761 aa)
rps27aRibosomal protein S27a. (156 aa)
LOC109963380Proteasome subunit alpha type. (261 aa)
orc5Origin recognition complex, subunit 5. (442 aa)
ENSMALP00000020785Histone H2B; Belongs to the histone H2B family. (115 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (314 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (432 aa)
ENSMALP00000020293Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC109962028Proteasome subunit beta11b. (387 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
rhno1Si:ch73-352p4.5. (299 aa)
ENSMALP000000191133-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (234 aa)
LOC109962801Proteasome 26S subunit, non-ATPase 11b. (422 aa)
ywhaz14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
ccnb3Cyclin B3; Belongs to the cyclin family. (450 aa)
orc2Origin recognition complex, subunit 2. (530 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1078 aa)
cntd2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (375 aa)
rpa2Replication protein A2. (278 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
orc3Origin recognition complex, subunit 3. (720 aa)
LOC109959349Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (255 aa)
wee1Wee1-like protein kinase. (620 aa)
psmb2Proteasome subunit beta. (182 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (216 aa)
CLSPNClaspin. (1101 aa)
piezo1Piezo-type mechanosensitive ion channel component. (2593 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (573 aa)
LOC109951222Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (242 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (467 aa)
rad1RAD1 homolog (S. pombe). (287 aa)
psma5Proteasome subunit alpha type. (241 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (286 aa)
uimc1Uncharacterized protein. (1052 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (440 aa)
babam1BRISC and BRCA1 A complex member 1. (370 aa)
rmi2RecQ mediated genome instability 2. (139 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
exo1Exonuclease 1. (810 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
LOC109961851Wee1-like protein kinase. (543 aa)
LOC109957769Histone H2B; Belongs to the histone H2B family. (134 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (245 aa)
psma6Proteasome subunit alpha type. (246 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (822 aa)
LOC10995145814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
brca1Uncharacterized protein. (1177 aa)
exd2Exonuclease 3'-5' domain containing 2. (639 aa)
LOC109952335Histone H2B; Belongs to the histone H2B family. (123 aa)
mdc1Uncharacterized protein. (2021 aa)
atripUncharacterized protein. (545 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (395 aa)
Rnf168RING-type domain-containing protein. (111 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (382 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (943 aa)
LOC109973907Proteasome 26S subunit, non-ATPase 4a. (365 aa)
psma8Proteasome subunit alpha type. (278 aa)
psma3Proteasome subunit alpha type. (284 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
mcm3DNA helicase; Belongs to the MCM family. (816 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
meiobMethionine sulfoxide reductase B1b. (404 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
LOC109969836Proteasome subunit alpha type. (246 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (565 aa)
psma1Proteasome subunit alpha type. (266 aa)
ENSMALP00000016949Histone H2A; Belongs to the histone H2A family. (141 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (599 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2613 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (310 aa)
ywhaqTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (256 aa)
ube2nUbiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
mcm2DNA helicase; Belongs to the MCM family. (890 aa)
ENSMALP00000015333Proteasome subunit beta. (275 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
psmf1Proteasome inhibitor subunit 1. (274 aa)
LOC109962656Proteasome subunit beta. (281 aa)
Your Current Organism:
Monopterus albus
NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel
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