(52 nodes) Hedgehog signaling pathway network (Monopterus albus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EVC2	EvC ciliary complex subunit 2. (1322 aa)
	csnk1a1	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (353 aa)
	LOC109974648	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
	fbxw11	F-box and WD repeat domain containing 11a. (562 aa)
	LOC109965931	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (377 aa)
	gas1	Growth arrest-specific 1a. (248 aa)
	LOC109964789	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (405 aa)
	hhip	Hedgehog interacting protein. (698 aa)
	LOC109970578	CULLIN_2 domain-containing protein; Belongs to the cullin family. (713 aa)
	prkaca	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
	ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (422 aa)
	kif3a	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (678 aa)
	grk3	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
	LOC109955784	GLI family zinc finger 2b. (1432 aa)
	LOC109963107	Cyclin Dx; Belongs to the cyclin family. (319 aa)
	gpr161	G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (525 aa)
	ENSMALP00000009060	Uncharacterized protein. (113 aa)
	smurf1	E3 ubiquitin-protein ligase. (727 aa)
	lrp2	Low density lipoprotein receptor-related protein 2a. (4531 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (427 aa)
	LOC109963122	Speckle type BTB/POZ protein. (374 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (417 aa)
	gli2	Uncharacterized protein. (1506 aa)
	LOC109971855	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (421 aa)
	gli1	GLI family zinc finger 1. (1467 aa)
	LOC109964396	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (433 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	SMURF2	E3 ubiquitin-protein ligase. (776 aa)
	megf8	Multiple EGF-like-domains 8. (2907 aa)
	LOC109963353	Casein kinase 1, gamma 1; Belongs to the protein kinase superfamily. (461 aa)
	ENSMALP00000020793	Uncharacterized protein. (248 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (816 aa)
	LOC109969706	Cyclin D2, b; Belongs to the cyclin family. (294 aa)
	CSNK1D	Casein kinase 1 delta; Belongs to the protein kinase superfamily. (414 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (706 aa)
	dhh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (463 aa)
	LOC109958253	Uncharacterized protein; Belongs to the protein kinase superfamily. (382 aa)
	LOC109969766	Growth arrest-specific 1b. (258 aa)
	LOC109969198	Uncharacterized protein. (167 aa)
	sufu	Suppressor of fused homolog. (499 aa)
	ptch1	Patched 1. (1475 aa)
	ptch2	Patched 2. (1479 aa)
	cul1	Cullin 1b; Belongs to the cullin family. (776 aa)
	LOC109971536	Uncharacterized protein. (167 aa)
	LOC109957760	BCL2 apoptosis regulator b. (228 aa)
	LOC109957139	Speckle type BTB/POZ protein like b. (392 aa)
	LOC109957708	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	mgrn1	Mahogunin, ring finger 1b. (548 aa)
	csnk1g2	Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (439 aa)
	ccnd2	Cyclin D2, a; Belongs to the cyclin family. (297 aa)
	boc	BOC cell adhesion associated, oncogene regulated. (1049 aa)
	arrb2	Arrestin, beta 2a. (418 aa)

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSNK1D	LOC109957708	ENSMALP00000021321	ENSMALP00000029745	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.730
CSNK1D	LOC109958253	ENSMALP00000021321	ENSMALP00000022903	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.730
CSNK1D	LOC109964789	ENSMALP00000021321	ENSMALP00000002593	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.900
CSNK1D	LOC109965931	ENSMALP00000021321	ENSMALP00000001985	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.730
CSNK1D	csnk1a1	ENSMALP00000021321	ENSMALP00000000855	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.585
CSNK1D	fbxw11	ENSMALP00000021321	ENSMALP00000001962	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	F-box and WD repeat domain containing 11a.	0.727
CSNK1D	grk3	ENSMALP00000021321	ENSMALP00000008568	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.900
CSNK1D	gsk3b	ENSMALP00000021321	ENSMALP00000011239	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily.	0.466
CSNK1D	prkaca	ENSMALP00000021321	ENSMALP00000005004	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily.	0.730
CSNK1D	smo	ENSMALP00000021321	ENSMALP00000020954	Casein kinase 1 delta; Belongs to the protein kinase superfamily.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.907
CUL3	ENSMALP00000009060	ENSMALP00000021376	ENSMALP00000009060	Cullin 3; Belongs to the cullin family.	Uncharacterized protein.	0.950
CUL3	LOC109955784	ENSMALP00000021376	ENSMALP00000008755	Cullin 3; Belongs to the cullin family.	GLI family zinc finger 2b.	0.950
CUL3	LOC109957139	ENSMALP00000021376	ENSMALP00000027524	Cullin 3; Belongs to the cullin family.	Speckle type BTB/POZ protein like b.	0.988
CUL3	LOC109963107	ENSMALP00000021376	ENSMALP00000008848	Cullin 3; Belongs to the cullin family.	Cyclin Dx; Belongs to the cyclin family.	0.538
CUL3	LOC109963122	ENSMALP00000021376	ENSMALP00000011434	Cullin 3; Belongs to the cullin family.	Speckle type BTB/POZ protein.	0.988
CUL3	LOC109969706	ENSMALP00000021376	ENSMALP00000021030	Cullin 3; Belongs to the cullin family.	Cyclin D2, b; Belongs to the cyclin family.	0.587
CUL3	LOC109970578	ENSMALP00000021376	ENSMALP00000003719	Cullin 3; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.900
CUL3	ccnd1	ENSMALP00000021376	ENSMALP00000018623	Cullin 3; Belongs to the cullin family.	Cyclin D1; Belongs to the cyclin family.	0.587
CUL3	ccnd2	ENSMALP00000021376	ENSMALP00000030793	Cullin 3; Belongs to the cullin family.	Cyclin D2, a; Belongs to the cyclin family.	0.587
CUL3	csnk1a1	ENSMALP00000021376	ENSMALP00000000855	Cullin 3; Belongs to the cullin family.	Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily.	0.622