(65 nodes) VEGF signaling pathway network (Monopterus albus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (734 aa)
	LOC109951184	Serine/threonine-protein phosphatase. (511 aa)
	LOC109962723	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1314 aa)
	hspb1	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (203 aa)
	ENSMALP00000001199	Phosphoinositide phospholipase C. (486 aa)
	LOC109955938	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (535 aa)
	LOC109968203	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (652 aa)
	LOC109957384	Uncharacterized protein. (717 aa)
	LOC109955902	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (405 aa)
	LOC109974067	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1059 aa)
	LOC109967181	Mitogen-activated protein kinase. (349 aa)
	LOC109968874	Uncharacterized protein. (226 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (472 aa)
	LOC109970672	Uncharacterized protein. (467 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
	LOC109967219	Mitogen-activated protein kinase. (363 aa)
	LOC109974179	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	sphk2	Sphingosine kinase 2. (891 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (438 aa)
	LOC109970170	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
	LOC109966668	Rac family small GTPase 3b. (192 aa)
	LOC109973708	PLA2c domain-containing protein. (551 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	LOC109957510	Serine/threonine-protein phosphatase. (512 aa)
	LOC109970803	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (203 aa)
	SRC	Tyrosine-protein kinase. (544 aa)
	LOC109954503	RHD domain-containing protein. (881 aa)
	LOC109952640	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (197 aa)
	LOC109960381	V-akt murine thymoma viral oncogene homolog 2, like; Belongs to the protein kinase superfamily. (439 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1351 aa)
	LOC109971977	Cell division cycle 42. (191 aa)
	CDC42	Cell division cycle 42. (191 aa)
	LOC109954803	Serine/threonine-protein phosphatase. (479 aa)
	LOC109975044	Rac family small GTPase 2. (192 aa)
	MAPKAPK3	MAPK activated protein kinase 3. (682 aa)
	RAC1	Rac family small GTPase 1. (192 aa)
	LOC109973830	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
	LOC109972703	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	LOC109971535	Protein kinase C. (670 aa)
	LOC109971550	Uncharacterized protein. (192 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
	LOC109966856	Uncharacterized protein. (425 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (870 aa)
	LOC109970991	Tyrosine-protein kinase. (543 aa)
	pik3r3	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (732 aa)
	bad	BCL2 associated agonist of cell death b. (168 aa)
	LOC109969176	Mitogen-activated protein kinase. (360 aa)
	LOC109958866	DAGKc domain-containing protein. (255 aa)
	LOC109964050	SHC (Src homology 2 domain containing) transforming protein 2. (721 aa)
	pla2g4a	Phospholipase A2. (734 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (604 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC109958888	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (393 aa)
	LOC109956193	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (381 aa)
	LOC109958833	Zgc:55558. (187 aa)
	ppp3r1	Protein phosphatase 3 regulatory subunit B, alpha. (170 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1037 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	raf1	Raf-1 proto-oncogene, serine/threonine kinase a. (635 aa)
	LOC109961826	Mitogen-activated protein kinase. (361 aa)
	LOC109966191	Uncharacterized protein. (235 aa)
	sphk1	Sphingosine kinase 1. (493 aa)

Your Current Organism:

Monopterus albus

NCBI taxonomy Id: 43700
Other names: Fluta alba, M. albus, Muraena alba, rice-field eel, swamp eel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ENSMALP00000001199	ENSMALP00000019476	ENSMALP00000001199	Cell division cycle 42.	Phosphoinositide phospholipase C.	0.442
CDC42	LOC109952640	ENSMALP00000019476	ENSMALP00000017751	Cell division cycle 42.	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family.	0.499
CDC42	LOC109955902	ENSMALP00000019476	ENSMALP00000006428	Cell division cycle 42.	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.	0.488
CDC42	LOC109955938	ENSMALP00000019476	ENSMALP00000001549	Cell division cycle 42.	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.	0.509
CDC42	LOC109956193	ENSMALP00000019476	ENSMALP00000028866	Cell division cycle 42.	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	0.531
CDC42	LOC109957384	ENSMALP00000019476	ENSMALP00000005739	Cell division cycle 42.	Uncharacterized protein.	0.495
CDC42	LOC109960381	ENSMALP00000019476	ENSMALP00000018024	Cell division cycle 42.	V-akt murine thymoma viral oncogene homolog 2, like; Belongs to the protein kinase superfamily.	0.426
CDC42	LOC109961826	ENSMALP00000019476	ENSMALP00000032041	Cell division cycle 42.	Mitogen-activated protein kinase.	0.945
CDC42	LOC109962723	ENSMALP00000019476	ENSMALP00000001005	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.426
CDC42	LOC109966668	ENSMALP00000019476	ENSMALP00000014729	Cell division cycle 42.	Rac family small GTPase 3b.	0.602
CDC42	LOC109967181	ENSMALP00000019476	ENSMALP00000007942	Cell division cycle 42.	Mitogen-activated protein kinase.	0.945
CDC42	LOC109967219	ENSMALP00000019476	ENSMALP00000011079	Cell division cycle 42.	Mitogen-activated protein kinase.	0.945
CDC42	LOC109969176	ENSMALP00000019476	ENSMALP00000027326	Cell division cycle 42.	Mitogen-activated protein kinase.	0.945
CDC42	LOC109970991	ENSMALP00000019476	ENSMALP00000027113	Cell division cycle 42.	Tyrosine-protein kinase.	0.517
CDC42	LOC109971550	ENSMALP00000019476	ENSMALP00000026082	Cell division cycle 42.	Uncharacterized protein.	0.607
CDC42	LOC109972703	ENSMALP00000019476	ENSMALP00000025855	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.426
CDC42	LOC109975044	ENSMALP00000019476	ENSMALP00000022550	Cell division cycle 42.	Rac family small GTPase 2.	0.602
CDC42	MAPKAPK3	ENSMALP00000019476	ENSMALP00000023529	Cell division cycle 42.	MAPK activated protein kinase 3.	0.488
CDC42	RAC1	ENSMALP00000019476	ENSMALP00000024025	Cell division cycle 42.	Rac family small GTPase 1.	0.607
CDC42	SRC	ENSMALP00000019476	ENSMALP00000016910	Cell division cycle 42.	Tyrosine-protein kinase.	0.517