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SdhB1 SdhB1 sdhA sdhA ilvN ilvN ilvB ilvB ScoB ScoB ScoA ScoA ORL35396.1 ORL35396.1 sdhC sdhC sdhD sdhD sdhA-2 sdhA-2 sdhB sdhB ORL33231.1 ORL33231.1 ORL33276.1 ORL33276.1 ORL33436.1 ORL33436.1 ORL34090.1 ORL34090.1 ORL33760.1 ORL33760.1 ORL33813.1 ORL33813.1 ORL33851.1 ORL33851.1 ORL33859.1 ORL33859.1 ORL33901.1 ORL33901.1 ORL33933.1 ORL33933.1 ORL33948.1 ORL33948.1 ORL33951.1 ORL33951.1 ORL33952.1 ORL33952.1 ORL34033.1 ORL34033.1 ORL32939.1 ORL32939.1 ORL32178.1 ORL32178.1 ORL32945.1 ORL32945.1 ORL32223.1 ORL32223.1 ORL32227.1 ORL32227.1 ORL32344.1 ORL32344.1 ORL32348.1 ORL32348.1 ORL32396.1 ORL32396.1 ORL32502.1 ORL32502.1 ORL32505.1 ORL32505.1 ORL32560.1 ORL32560.1 ORL32561.1 ORL32561.1 ORL32577.1 ORL32577.1 ORL32647.1 ORL32647.1 ORL32870.1 ORL32870.1 ORL32877.1 ORL32877.1 ORL32881.1 ORL32881.1 ORL32886.1 ORL32886.1 ORL32887.1 ORL32887.1 ORL32897.1 ORL32897.1 ORL32901.1 ORL32901.1 ORL31980.1 ORL31980.1 gabD gabD ORL31340.1 ORL31340.1 ORL31625.1 ORL31625.1 ORL31559.1 ORL31559.1 ORL31589.1 ORL31589.1 ORL31014.1 ORL31014.1 ORL31016.1 ORL31016.1 gabD2 gabD2 gabT gabT ORL30898.1 ORL30898.1 ORL30571.1 ORL30571.1 ORL30572.1 ORL30572.1 ORL30593.1 ORL30593.1 ORL30110.1 ORL30110.1 ORL30044.1 ORL30044.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SdhB1Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (643 aa)
ilvNAcetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
ilvBAcetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (601 aa)
ScoBsuccinyl-CoA--3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
ScoAsuccinyl-CoA--3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
ORL35396.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
sdhCSuccinate dehydrogenase, cytochrome b556 subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (111 aa)
sdhDSuccinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
sdhA-2Fumarate reductase (quinol) flavoprotein subunit; Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
ORL33231.1acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (653 aa)
ORL33276.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
ORL33436.13-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
ORL34090.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (445 aa)
ORL33760.1Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (314 aa)
ORL33813.13-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
ORL33851.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (382 aa)
ORL33859.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (263 aa)
ORL33901.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
ORL33933.1Butanediol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
ORL33948.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (249 aa)
ORL33951.1succinyl-CoA--3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
ORL33952.1succinyl-CoA--3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
ORL34033.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
ORL32939.1hydroxymethylglutaryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (310 aa)
ORL32178.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (253 aa)
ORL32945.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
ORL32223.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (269 aa)
ORL32227.13-hydroxybutyryl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
ORL32344.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (405 aa)
ORL32348.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
ORL32396.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
ORL32502.1NAD-dependent succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (487 aa)
ORL32505.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (255 aa)
ORL32560.1succinyl-CoA--3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
ORL32561.1succinyl-CoA--3-ketoacid-CoA transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
ORL32577.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (243 aa)
ORL32647.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (551 aa)
ORL32870.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
ORL32877.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
ORL32881.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
ORL32886.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
ORL32887.1CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
ORL32897.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (384 aa)
ORL32901.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
ORL31980.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
gabDSuccinic semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (517 aa)
ORL31340.1CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
ORL31625.1Glutamate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the group II decarboxylase family. (449 aa)
ORL31559.1NAD-dependent succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (486 aa)
ORL31589.1acetyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (521 aa)
ORL31014.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
ORL31016.13-hydroxyisobutyryl-CoA hydrolase; Catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
gabD2NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
gabT4-aminobutyrate--2-oxoglutarate transaminase; Catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa)
ORL30898.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
ORL30571.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
ORL30572.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (713 aa)
ORL30593.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
ORL30110.1enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (276 aa)
ORL30044.1Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
Your Current Organism:
Rhodococcus hoagii
NCBI taxonomy Id: 43767
Other names: ATCC 14887 [[Nocardia restricta]], ATCC 25729 [[Rhodococcus equi]], ATCC 6939 [[Rhodococcus equi]], ATCC 7005 [[Corynebacterium hoagii]], Bacillus hoagii, CCUG 17758 [[Nocardia restricta]], CCUG 20991 [[Corynebacterium hoagii]], CCUG 892 [[Rhodococcus equi]], CIP 54.72 [[Rhodococcus equi]], CIP 81.17 [[Corynebacterium hoagii]], Corynebacterium (pyogenes) equi roseum, Corynebacterium hoagii, Corynebacterium magnusson-holth, Corynebacterium purulentus, Corynebacterium pyogenes (equi), DSM 20295 [[Corynebacterium hoagii]], DSM 20307 [[Rhodococcus equi]], DSM 43199 [[Nocardia restricta]], HAMBI 2061 [[Rhodococcus equi]], IFO 14956 [[Rhodococcus equi]], JCM 3209 [[Rhodococcus equi]], JCM 3223 [[Nocardia restricta]], LMG 18452 [[Rhodococcus equi]], LMG 7335 [[Nocardia restricta]], LMG:18452 [[Rhodococcus equi]], LMG:7335 [[Nocardia restricta]], Mycobacterium equi, Mycobacterium restrictum, NBRC 101255 [[Rhodococcus equi]], NBRC 103062 [[Corynebacterium hoagii]], NBRC 14956 [[Rhodococcus equi]], NCTC 10673 [[Corynebacterium hoagii]], NRRL B-16538 [[Rhodococcus equi]], Nocardia restricta, Prescottella equi, Prescottia equi, Proactinomyces restrictus, R. hoagii, Rhodococcus equi, VKM Ac-953 [[Rhodococcus equi]]
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